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    BCAN brevican [ Homo sapiens ]

    Gene ID: 63827, updated on 11-May-2012

    Summary

    Official Symbol
    BCANprovided by HGNC
    Official Full Name
    brevicanprovided by HGNC
    Primary source
    HGNC:23059
    Locus tag
    RP11-66D17.1
    See related
    Ensembl:ENSG00000132692; HPRD:02644; HPRD:09821; MIM:600347; Vega:OTTHUMG00000033322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BEHAB; CSPG7; MGC13038
    Summary
    This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

    Genomic context

    Location :
    1q31
    Sequence :
    Chromosome: 1; NC_000001.10 (156611740..156629320)
    See BCAN in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene G patch domain containing 4 Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene nestin Neighboring gene cellular retinoic acid binding protein 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96GW7 O75173 ADAMTS4    HPRD  PubMed  
    Q96GW7 P98095 FBLN2    HPRD  PubMed  
    Q96GW7 P03956 MMP1    HPRD  PubMed  
    Q96GW7 P09238 MMP10    HPRD  PubMed  
    Q96GW7 P45452 MMP13    HPRD  PubMed  
    Q96GW7 P08253 MMP2    HPRD  PubMed  
    Q96GW7 P08254 MMP3    HPRD  PubMed  
    Q96GW7 P09237 MMP7    HPRD  PubMed  
    Q96GW7 P22894 MMP8    HPRD  PubMed  
    Q96GW7 Q92752 TNR    HPRD  PubMed  
    BioGRID:121964 BioGRID:108493 FBLN2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121964 BioGRID:110456 MMP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:121964 BioGRID:110462 MMP10    BioGRID  PubMed Biochemical Activity 
    BioGRID:121964 BioGRID:110465 MMP13    BioGRID  PubMed Biochemical Activity 
    BioGRID:121964 BioGRID:110457 MMP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:121964 BioGRID:110458 MMP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:121964 BioGRID:110459 MMP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:121964 BioGRID:110460 MMP8    BioGRID  PubMed Biochemical Activity 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
     
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    anchored to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    brevican core protein
    Names
    brevican core protein
    chondroitin sulfate proteoglycan 7
    chondroitin sulfate proteoglycan BEHAB
    brain-enriched hyaluronan-binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030013.1 RefSeqGene

      Range
      5001..22585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021948.4NP_068767.3  brevican core protein isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL365181, AL590666, AY358372, BC027971, DB297352
      Consensus CDS
      CCDS1149.1
      UniProtKB/Swiss-Prot
      Q96GW7
      Related
      ENSP00000331210, OTTHUMP00000032164, ENST00000329117, OTTHUMT00000081844
      Conserved Domains (7) summary
      cd00054
      Location:652682
      Blast Score: 99
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:157251
      Blast Score: 436
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:258353
      Blast Score: 429
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd00033
      Location:815872
      Blast Score: 121
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam07686
      Location:42154
      Blast Score: 124
      V-set; Immunoglobulin V-set domain
      cl02432
      Location:688811
      Blast Score: 601
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cl11960
      Location:49158
      Blast Score: 331
      Ig; Immunoglobulin domain
    2. NM_198427.1NP_940819.1  brevican core protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF229053, AW298823, AY358372
      Consensus CDS
      CCDS1150.1
      UniProtKB/Swiss-Prot
      Q96GW7
      Related
      ENSP00000354925, OTTHUMP00000032165, ENST00000361588, OTTHUMT00000081845
      Conserved Domains (4) summary
      cd03517
      Location:157251
      Blast Score: 438
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:258353
      Blast Score: 431
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      pfam07686
      Location:42154
      Blast Score: 125
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:49158
      Blast Score: 327
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      156611740..156629320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      127969333..127986918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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