BIK BCL2-interacting killer (apoptosis-inducing) [Homo sapiens] - Gene

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Summary

Official Symbol: BIKprovided by HGNC
Official Full Name: BCL2-interacting killer (apoptosis-inducing)provided by HGNC
Primary source: HGNC:1051
See related: Ensembl:ENSG00000100290; HPRD:04547; MIM:603392; Vega:OTTHUMG00000150703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BP4; NBK; BIP1
Summary: The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

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Genomic context

Location :: 22q13.31

Sequence :: Chromosome: 22; NC_000022.10 (43506757..43525718)

See BIK in Epigenomics, MapViewer

Chromosome 22 - NC_000022.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that association of study-wide significance (P < 8.2 x 10(-5)) was identified for single-nucleotide polymorphisms (SNP) in TP53, LIG1, and BIK.
Title: Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.
GRP78 can decrease BCL-2 sequestration by BIK at the endoplasmic reticulum
Title: Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).
Bik has a role in both, apoptosis induction and sensitivity to oxidative stress in myeloma cells.
Title: BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
genetic polymorphism in patients with ataxia telangiectasia is associated with the disease progression
Title: BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia.
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
BIK might not play a major role in the susceptibility of schizophrenia in Japanese population.
Title: No association between the Bcl2-interacting killer (BIK) gene and schizophrenia.

Submit: New GeneRIF Correction See all (28)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001188.1	NP_000624.1	BCL2	BIND	PubMed	Bik interacts with Bcl-2.
NP_001188.1	NP_000624.1	BCL2	BIND	PubMed	Bcl-2 interacts with Bik.
NP_001188.1	NP_004040.1	BCL2A1	BIND	PubMed	Bik interacts with A1. This interaction was modelled on a demonstrated interaction between human Bik and mouse A1.
NP_001188.1	NP_612815.1	BCL2L1	BIND	PubMed	Bik interacts with Bcl-XL.
NP_001188.1	NP_612815.1	BCL2L1	BIND	PubMed	Bcl-XL interacts with Bik. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bik.
NP_001188.1	NP_004041.1	BCL2L2	BIND	PubMed	Bik interacts with Bcl-w.
NP_001188.1	NP_001708.2	BNC1	BIND	PubMed	Bik interacts with Mcl-1. This interaction was modelled on a demonstrated interaction between human Bik and mouse Mcl-1.
Q13323	P10415	BCL2	HPRD	PubMed
Q13323	Q16548	BCL2A1	HPRD	PubMed
Q13323	Q07817	BCL2L1	HPRD	PubMed
Q13323	Q92843	BCL2L2	HPRD	PubMed
Q13323	Q07820	MCL1	HPRD	PubMed
BioGRID:107107	BioGRID:107068	BCL2	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:107107	BioGRID:107069	BCL2A1	BioGRID	PubMed	Protein-peptide
BioGRID:107107	BioGRID:107070	BCL2L1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Two-hybrid
BioGRID:107107	BioGRID:107071	BCL2L2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107107	BioGRID:110338	MCL1	BioGRID	PubMed	Protein-peptide; Reconstituted Complex
BioGRID:107107	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
BH domain binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
induction of apoptosis	TAS Traceable Author Statement more info	PubMed
male gonad development	IEA Inferred from Electronic Annotation more info
positive regulation of protein homooligomerization	IDA Inferred from Direct Assay more info
positive regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info
regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endomembrane system	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial envelope	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: bcl-2-interacting killer

Names: bcl-2-interacting killer; apoptosis inducer NBK; apoptosis-inducing NBK

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197.4 → NP_001188.1 bcl-2-interacting killer

Status: REVIEWED

Source sequence(s)

BC001599, BP329261, U34584

Consensus CDS

CCDS14044.1

UniProtKB/Swiss-Prot

Q13323

Related

ENSP00000216115, OTTHUMP00000198290, ENST00000216115, OTTHUMT00000319676

Conserved Domains (1) summary

pfam12201
Location:1 – 136
Blast Score: 596

bcl-2I13; Theoretical model of a pro-apoptotic protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000022.10 Reference GRCh37.p5 Primary Assembly

Range

43506757..43525718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000154.1 Alternate HuRef

Range

26465063..26484115

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF174424.1	AAF01156.1
genomic	AL022237.1	CAA18260.2
genomic	AY245248.1	AAO61089.1
genomic	CH471138.1	EAW73282.1
		EAW73283.1
		EAW73284.1
mRNA	BC001599.1	AAH01599.1
mRNA	BM765910.1	None
mRNA	BP329261.1	None
mRNA	BT006728.1	AAP35374.1
mRNA	CR456390.1	CAG30276.1
mRNA	CR541863.1	CAG46661.1
mRNA	CR541883.1	CAG46681.1
mRNA	U34584.1	AAC50413.1
mRNA	U49730.1	AAC79124.1
other-genetic	CU012948.1	CAK54379.1
other-genetic	CU013236.1	CAK54678.1
other-genetic	DQ890578.2	ABM92195.1
other-genetic	DQ893738.2	ABM84664.1
other-genetic	DQ893745.2	ABM84671.1