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    BID BH3 interacting domain death agonist [ Homo sapiens ]

    Gene ID: 637, updated on 19-May-2012
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    Summary

    Official Symbol
    BIDprovided by HGNC
    Official Full Name
    BH3 interacting domain death agonistprovided by HGNC
    Primary source
    HGNC:1050
    See related
    Ensembl:ENSG00000015475; HPRD:03590; MIM:601997; Vega:OTTHUMG00000150087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FP497; MGC15319; MGC42355
    Summary
    This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    22q11.1
    Sequence :
    Chromosome: 22; NC_000022.10 (18216906..18257258, complement)
    See BID in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 Neighboring gene BCL2-like 13 (apoptosis facilitator) Neighboring gene microRNA 3198-1 Neighboring gene long intergenic non-protein coding RNA 528 Neighboring gene uncharacterized LOC100506240 Neighboring gene microtubule associated monoxygenase, calponin and LIM domain containing 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling. Garcia-Perez C, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22393005.
    2. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. Henry RE, et al. EMBO J, 2012 Jan 13. PMID 22246181.
    3. BID is a critical factor controlling cell viability regulated by IFN-α. Tsuno T, et al. J Immunother, 2012 Jan. PMID 22130162.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.

    See all (159) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Bid engages a ROS-dependent, local intermitochondrial potentiation mechanism that amplifies the apoptotic signal as a wave
      Title: Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling.
    2. The key differential events in apoptotic cells are p53-dependent activation of the DR4 death receptor pathway, caspase 8-mediated cleavage of BID, and BID-dependent activation of poised BAX at the mitochondria.
      Title: A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.
    3. critical for controlling cell viability regulated by IFN-alpha in ovarian adenocarcinoma cells
      Title: BID is a critical factor controlling cell viability regulated by IFN-α.
    4. chronic ethanol increases CYP2E1 activity in adipose, leading to Bid-mediated apoptosis and activation of complement via C1q
      Title: Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice.
    5. Data show that G-Rh2 and Bet A cooperated to induce Bax traslocation to mitochondria and cytochrome c release, and enhanced cleavage of caspase-8 and Bid.
      Title: Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.
    6. propose a model in which BID associates with RPA and stimulates the recruitment and/or stabilization of ATR-ATRIP to the DNA damage sensor complex
      Title: BID binds to replication protein A and stimulates ATR function following replicative stress.
    7. show that due to the high affinity of BAX for BCL-2, BCL-w and A1, and of BAK for BCL-X(L), MCL-1 and A1, only a subset of BH3-only proteins, including BID, could be expected to free BAX or BAK from the antiapoptotic BCL-2 proteins to elicit apoptosis
      Title: Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX.
    8. Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis.
      Title: Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis.
    9. a direct role for the BH3 interacting domain death agonist acting at the level of the DNA damage sensor complex to amplify the Atr-directed cellular response to replicative damage
      Title: Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
    10. Data show that the expression of apoptosis proteins caspase-3,-8,-9, and Bid in the RNP of the disc and the SNP was different in each patient.
      Title: Apoptosis in the sequestrated nucleus pulposus compared to the remaining nucleus pulposus in the same patient.
    Submit: New GeneRIF Correction See all (99)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001187.1 NP_620116.1 BAX    BIND  PubMed Bax interacts with Bid. 
    NP_001187.1 NP_000624.1 BCL2    BIND  PubMed Bid interacts with Bcl-2. 
    NP_001187.1 BCL2    BIND  PubMed Bid interacts with Bcl-2. 
    NP_001187.1 NP_004040.1 BCL2A1    BIND  PubMed Bid interacts with A1. This interaction was modelled on a demonstrated interaction between human Bid and mouse A1. 
    NP_001187.1 NP_612815.1 BCL2L1    BIND  PubMed BCL-XL interacts with the alpha-helical region of the BID BH3 death domain. 
    NP_001187.1 NP_612815.1 BCL2L1    BIND  PubMed Bid interacts with Bcl-XL. 
    NP_001187.1 NP_612815.1 BCL2L1    BIND  PubMed Bid interacts with Bcl-xL. 
    NP_001187.1 NP_004041.1 BCL2L2    BIND  PubMed Bid interacts with Bcl-w. 
    NP_001187.1 NP_001708.2 BNC1    BIND  PubMed Bid interacts with Mcl-1. This interaction was modelled on a demonstrated interaction between human Bid and mouse Mcl-1. 
    NP_001187.1 NP_056012.1 PACS2    BIND  PubMed PACS2 interacts with BID. 
    NP_932070.1 NP_612815.1 BCL2L1    BIND  PubMed BCL-XL interacts with the alpha-helical region of the BID-EL BH3 death domain. 
    P55957 Q16611 BAK1    HPRD  PubMed  
    P55957 Q07814 BAX    HPRD  PubMed  
    P55957 P10415 BCL2    HPRD  PubMed  
    P55957 Q16548 BCL2A1    HPRD  PubMed  
    P55957 Q07817 BCL2L1    HPRD  PubMed  
    P55957 Q92843 BCL2L2    HPRD  PubMed  
    P55957 P55957 BID    HPRD  PubMed  
    P55957 P07384 CAPN1    HPRD  PubMed  
    P55957 P29466 CASP1    HPRD  PubMed  
    P55957 Q92851 CASP10    HPRD  PubMed  
    P55957 P42575 CASP2    HPRD  PubMed  
    P55957 P42574 CASP3    HPRD  PubMed  
    P55957 Q14790 CASP8    HPRD  PubMed  
    P55957 P48729 CSNK1A1    HPRD  PubMed  
    P55957 P49674 CSNK1E    HPRD  PubMed  
    P55957 P68400 CSNK2A1    HPRD  PubMed  
    P55957 P19784 CSNK2A2    HPRD  PubMed  
    P55957 P67870 CSNK2B    HPRD  PubMed  
    P55957 P10144 GZMB    HPRD  PubMed  
    P55957 Q07820 MCL1    HPRD  PubMed  
    P55957 P31946 YWHAB    HPRD  PubMed  
    BioGRID:107106 BioGRID:106889 ARHGDIA    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:107068 BCL2    BioGRID  PubMed Protein-peptide 
    BioGRID:107106 BioGRID:107069 BCL2A1    BioGRID  PubMed Affinity Capture-Western 
    NP_612815.1 BCL2L1    BIND  PubMed Bcl-XL interacts with Bid. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bid. 
    BioGRID:107106 BioGRID:107070 BCL2L1    BioGRID  PubMed Protein-peptide 
    BioGRID:107106 BioGRID:107071 BCL2L2    BioGRID  PubMed Protein-peptide 
    BioGRID:107106 BioGRID:107106 BID    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107106 BioGRID:116332 C14orf1    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:107274 CAPN2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107106 BioGRID:107293 CASP10    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:107285 CASP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107106 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107106 BioGRID:107291 CASP8    BioGRID  PubMed Biochemical Activity; Co-purification 
    BioGRID:107106 BioGRID:107790 CRMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:119487 CRNKL1    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:113271 EZR    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:114302 FADD    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:106851 FAS    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:106852 FASLG    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:124100 FBN3    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:108868 GAPDH    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:108904 GBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107106 BioGRID:111585 MAPK8    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:110338 MCL1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107106 BioGRID:110584 MSN    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:115178 PLEKHM1    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:106880 RHOA    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:114323 TNFRSF10B    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Co-purification 
    BioGRID:107106 BioGRID:131483 TUBB2B    BioGRID  PubMed Two-hybrid 
    BioGRID:107106 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107106 BioGRID:116406 ZHX1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation and oligomerization of BAK protein, organism-specific biosystem (from REACTOME)
      Activation and oligomerization of BAK protein, organism-specific biosystemtBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cy...
    • Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of BAD and translocation to mitochondria, organism-specific biosystemThe switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activate...
    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
    • Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemBID may promote cell death by activating BAX and BAK while inactivating anti-apoptotic proteins. The engagement of cell surface receptors activates the caspase-8, a heterodimer, that cleaves BID in i...
    • Activation, translocation and oligomerization of BAX, organism-specific biosystem (from REACTOME)
      Activation, translocation and oligomerization of BAX, organism-specific biosystemAs a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may repr...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation by HSP70, organism-specific biosystem
      Apoptosis Modulation by HSP70
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    death receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of pro-apoptotic gene products TAS
    Traceable Author Statement
    more info
    		  
    apoptotic mitochondrial changes TAS
    Traceable Author Statement
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment of protein localization in membrane IDA
    Inferred from Direct Assay
    more info
    		  
    glial cell apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis via death domain receptors TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neuron apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of protein oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    		  
    positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    integral to mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    BH3-interacting domain death agonist
    Names
    BH3-interacting domain death agonist
    p22 BID
    BID isoform Si6
    BID isoform L(2)
    BID isoform ES(1b)
    desmocollin type 4
    apoptic death agonist
    Human BID coding sequence
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001196.3 → NP_001187.1  BH3-interacting domain death agonist isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, BM561391, BM842561
      Consensus CDS
      CCDS13748.1
      UniProtKB/TrEMBL
      A8ASI8
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Related
      ENSP00000382674, OTTHUMP00000196194, ENST00000399774, OTTHUMT00000316178
      Conserved Domains (1) summary
      pfam06393
      Location:1 – 192
      Blast Score: 706
      BID; BH3 interacting domain (BID)

    2. NM_001244567.1 → NP_001231496.1  BH3-interacting domain death agonist isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, EU678294
      UniProtKB/TrEMBL
      A8ASI8
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Conserved Domains (1) summary
      pfam06393
      Location:1 – 192
      Blast Score: 706
      BID; BH3 interacting domain (BID)

    3. NM_001244569.1 → NP_001231498.1  BH3-interacting domain death agonist isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, CN277529, DA158889
      UniProtKB/TrEMBL
      B2ZP79
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Conserved Domains (1) summary
      pfam06393
      Location:1 – 96
      Blast Score: 346
      BID; BH3 interacting domain (BID)

    4. NM_001244570.1 → NP_001231499.1  BH3-interacting domain death agonist isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA007047, DA158889
      UniProtKB/TrEMBL
      B2ZP79
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Conserved Domains (1) summary
      pfam06393
      Location:1 – 96
      Blast Score: 346
      BID; BH3 interacting domain (BID)

    5. NM_001244572.1 → NP_001231501.1  BH3-interacting domain death agonist isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate coding exons compared to variant 1, that causes a frameshift. This variant uses a downstream in-frame start-codon, so the encoded isoform 3 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA274603, DB167767
      UniProtKB/TrEMBL
      B2ZP79
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Conserved Domains (1) summary
      pfam06393
      Location:1 – 96
      Blast Score: 346
      BID; BH3 interacting domain (BID)

    6. NM_197966.2 → NP_932070.1  BH3-interacting domain death agonist isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC006285, AF250233, AK094795, BC036364, DA274603
      Consensus CDS
      CCDS13747.1
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Related
      ENSP00000318822, OTTHUMP00000196195, ENST00000317361, OTTHUMT00000316179
      Conserved Domains (1) summary
      pfam06393
      Location:47 – 238
      Blast Score: 713
      BID; BH3 interacting domain (BID)

    7. NM_197967.2 → NP_932071.1  BH3-interacting domain death agonist isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' region and uses a downstream start codon, as compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/TrEMBL
      B2ZP79
      UniProtKB/TrEMBL
      B3KT21
      UniProtKB/Swiss-Prot
      P55957
      Related
      ENSP00000382669, ENST00000399767
      Conserved Domains (1) summary
      pfam06393
      Location:1 – 96
      Blast Score: 346
      BID; BH3 interacting domain (BID)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      18216906..18257258, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      2030888..2070911, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006285.13 (122051..143372) None
    genomic AC016026.15 None
    genomic AY309922.1 AAP50259.1
    genomic CH471193.1 EAW57770.1
      EAW57771.1
      EAW57772.1
      EAW57773.1
      EAW57774.1
    genomic CQ786436.1 CAG17894.1
    mRNA AF042083.1 AAC34365.1
    mRNA AF087891.1 AAP97190.1
    mRNA AF250233.1 AAO32633.1
    mRNA AF370380.1 AAQ15216.1
    mRNA AK094795.1 BAG52933.1
    mRNA AK313729.1 BAG36471.1
    mRNA AY005151.1 AAF89091.1
    mRNA BC009197.2 AAH09197.1
    mRNA BC022072.1 AAH22072.2
    mRNA BC033634.1 AAH33634.1
    mRNA BC036364.1 AAH36364.2
    mRNA BM561391.1 None
    mRNA BM842561.1 None
    mRNA BQ068464.1 None
    mRNA CN277529.1 None
    mRNA CR407603.1 CAG28531.1
    mRNA CR456389.1 CAG30275.1
    mRNA D89803.1 BAF79673.1
    mRNA DA007047.1 None
    mRNA DA158889.1 None
    mRNA DA274603.1 None
    mRNA DB167767.1 None
    mRNA EU447348.1 ACA61804.1
    mRNA EU678292.1 ACD47106.1
    mRNA EU678293.1 ACD47107.1
    mRNA EU678294.1 ACD47108.1
    other-genetic CU012947.1 CAK54378.1
    other-genetic CU013235.1 CAK54677.1
    other-genetic EU446512.1 ABZ92041.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55957.1 GenPept UniProtKB/Swiss-Prot:P55957
    Q71RF7 GenPept UniProtKB/TrEMBL:Q71RF7
    Help top of page

    Additional Links

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