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CCL14 C-C motif chemokine ligand 14 [ Homo sapiens (human) ]

Gene ID: 6358, updated on 12-May-2016
Official Symbol
CCL14provided by HGNC
Official Full Name
C-C motif chemokine ligand 14provided by HGNC
Primary source
HGNC:HGNC:10612
See related
Ensembl:ENSG00000276409 HPRD:03231; MIM:601392; Vega:OTTHUMG00000138999; Vega:OTTHUMG00000188403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3
Summary
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
Orthologs
Location:
17q12
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (35983656..35986728, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34310692..34313764, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene lysozyme like 6 Neighboring gene uncharacterized LOC101927339 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene C-C motif chemokine ligand 15 Neighboring gene C-C motif chemokine ligand 23

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-C motif) ligand 14 (CCL14) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough CCL15-CCL14

Readthrough gene: CCL15-CCL14, Included gene: CCL15

Homology

Clone Names

  • FLJ16015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
C-C motif chemokine 14
Names
chemokine (C-C motif) ligand 14
chemokine CC-1/CC-3
chemokine CC-3
hemofiltrate CC chemokine 1
new CC chemokine 2
small inducible cytokine subfamily A (Cys-Cys), member 14
small-inducible cytokine A14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032962.4NP_116738.1  C-C motif chemokine 14 isoform 2 precursor

    See identical proteins and their annotated locations for NP_116738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as CCL14b) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AA612866, BC045165, BI496964, DA821276
    Consensus CDS
    CCDS45652.1
    UniProtKB/Swiss-Prot
    Q16627
    Related
    ENSP00000479097, OTTHUMP00000276524, ENST00000622526, OTTHUMT00000477121
    Conserved Domains (1) summary
    cd00272
    Location:51107
    Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...
  2. NM_032963.3NP_116739.1  C-C motif chemokine 14 isoform 1 precursor

    See identical proteins and their annotated locations for NP_116739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, CCL14a) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (1) lacks an alternate segment near the N-terminus, compared to isoform 2.
    Source sequence(s)
    DA821276
    Consensus CDS
    CCDS32624.1
    UniProtKB/Swiss-Prot
    Q16627
    Related
    ENSP00000481023, OTTHUMP00000276523, ENST00000618404, OTTHUMT00000477120
    Conserved Domains (1) summary
    cd00272
    Location:3591
    Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    35983656..35986728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    218220..221292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    34375227..34378299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004166.4: Suppressed sequence

    Description
    NM_004166.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.