CCL8 chemokine (C-C motif) ligand 8 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CCL8provided by HGNC
Official Full Name: chemokine (C-C motif) ligand 8provided by HGNC
Primary source: HGNC:10635
See related: Ensembl:ENSG00000108700; HPRD:03791; MIM:602283; Vega:OTTHUMG00000132883
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HC14; MCP2; MCP-2; SCYA8; SCYA10
Summary: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 17q11.2

Sequence :: Chromosome: 17; NC_000017.10 (32646066..32648421)

See CCL8 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.
Title: Macrophage colony stimulating factor and monocyte chemoattractant protein 2 are elevated in intrinsic asthmatics.
genetic polymorphhism is associated with a risk of death for non-small cell lung cancer in Chinese
Title: Polymorphisms of key chemokine genes and survival of non-small cell lung cancer in Chinese.
Cytokine treatment increases mRNA stability only for chemokines CCL2 and CCL8 in airway epithelium, and transient silencing and overexpression of human antigen R affects only chemokine CCL2 and CCL8 expression in primary and transformed epithelial cells.
Title: Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium.
CCL8/MCP-2 is a target for mir-146a in HIV-1 infected microglia, as overexpression of mir-146a prevented HIV-induced secretion of MCP-2 chemokine
Title: CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells.
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.
CCL8/MCP rs1133763 SNP, or other variants in linkage disequilibrium with this variant, likely do not influence the susceptibility to AD or FTLD in Caucasians.
Title: CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration.
IP-10 and MCP-2 are expressed in tuberculosis patients
Title: Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis.
These data indicate that optimal induction and delivery of MCP-2/CCL8 is counteracted by converting this chemokine into a receptor antagonist, thereby losing its anti-tumoral potential.
Title: Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
5-Amino-4-imidazole carboxamide riboside (AICAR) markedly increases UCP-2 expression and reduced both reactive oxygen species and prostacyclin synthase nitration.
Title: Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.

Submit: New GeneRIF Correction See all (18)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Chemokines such as MCP-3 and MCP-2 that can compete with high affinity for MIP-1beta binding to CCR5 can also compete for monomeric HIV-1 gp120 binding to CCR5, although with variable potencies	PubMed
Tat	tat	HIV-1 Tat upregulates expression of MCP-2 in immature dendritic cells, suggesting Tat reprograms host dendritic cell gene expression to facilitate expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
P80075	O00590	CCBP2	HPRD	PubMed
P80075	P32246	CCR1	HPRD	PubMed
P80075	P41597	CCR2	HPRD	PubMed
P80075	P51677	CCR3	HPRD	PubMed
P80075	P51681	CCR5	HPRD	PubMed
P80075	Q9NPB9	CCRL1	HPRD	PubMed
P80075	Q16570	DARC	HPRD	PubMed
P80075	P08254	MMP3	HPRD	PubMed
P80075	P13611	VCAN	HPRD	PubMed
BioGRID:112258	BioGRID:107643	CCBP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112258	BioGRID:107844	VCAN	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
chemokine activity	IEA Inferred from Electronic Annotation more info
heparin binding	IEA Inferred from Electronic Annotation more info
phospholipase activator activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
cellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
chemotaxis	IEA Inferred from Electronic Annotation more info
exocytosis	IDA Inferred from Direct Assay more info	PubMed
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
response to virus	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: C-C motif chemokine 8

Names: C-C motif chemokine 8; small-inducible cytokine A8; monocyte chemotactic protein 2; monocyte chemoattractant protein 2; small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005623.2 → NP_005614.2 C-C motif chemokine 8 precursor

Status: REVIEWED

Source sequence(s)

Y16645

Consensus CDS

CCDS11280.1

UniProtKB/Swiss-Prot

P80075

Related

ENSP00000225840, ENST00000225840

Conserved Domains (1) summary

cd00272
Location:34 – 91
Blast Score: 197

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

32646066..32648421

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

28831806..28834161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011193.3 (168953..171308)	None
genomic	CH471147.2	EAW80207.1
		EAW80208.1
genomic	X99886.1	CAA68168.1
genomic	Y18047.1	None
mRNA	BC126242.1	AAI26243.1
mRNA	Y10802.1	CAA71760.1
mRNA	Y16645.1	CAA76341.1
other-genetic	HQ258700.1	ADR83451.1