CCL1 chemokine (C-C motif) ligand 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CCL1provided by HGNC
Official Full Name: chemokine (C-C motif) ligand 1provided by HGNC
Primary source: HGNC:10609
See related: Ensembl:ENSG00000108702; HPRD:01654; MIM:182281; Vega:OTTHUMG00000132888
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P500; SISe; TCA3; I-309; SCYA1
Summary: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 17q12

Sequence :: Chromosome: 17; NC_000017.10 (32687399..32690252, complement)

See CCL1 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity
Title: C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.
There was a borderline association between a single nucleotide polymorphism located within the CCL1 gene and predisposition to tuberculosis using a singlepoint analysis
Title: Tuberculosis susceptibility genes in the chemokine cluster region of chromosome 17 in Hong Kong Chinese.
ACEI is effective in downregulating LPS-induced TNF-alpha, I-309, and IP-10, which play important roles in the pathogenesis of inflammation
Title: Suppressive effects of imidapril on Th1- and Th2-related chemokines in monocytes.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
The authors show here that PRV-gG binds to the human chemokine CL1 and several CC and CXC human chemokines with high affinity.
Title: Glycoprotein G from pseudorabies virus binds to chemokines with high affinity and inhibits their function.
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.
serum CCL1 levels were slightly, but statistically significantly, correlated with serum IgE levels in patients with bullous pemphigoid.
Title: Increased CCL1 levels in the sera and blister fluid of patients with bullous pemphigoid.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
6 single nucleotide polymorphisms in CCL1 were found to be associated with tuberculosis in a case-control genetic association study with 273 TB cases and 188 controls
Title: Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.

Submit: New GeneRIF Correction See all (20)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	HIV-1 Tat inhibits I-309 (CCL1) driven cell migration as demonstrated using Tat peptides containing CXC or CC-like sequences (Tat amino acids 25-27 and 30-31, respectively)	PubMed
Vpr, p15	vpr	HIV-1 Vpr downregulates the monocyte chemoattractant I-309)	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P22362	P51685	CCR8		HPRD	PubMed
P22362	Q7Z6Z7	HUWE1		HPRD	PubMed

Pathways from BioSystems

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Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483370

D17S1270 (e-PCR)
- UniSTS:149811

GDB:607775 (e-PCR)
- UniSTS:158285

NoName (e-PCR)
- UniSTS:481424

D17S1677 (e-PCR)
- UniSTS:82066

Homology

Homologs of the CCL1 gene: The CCL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
chemokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
chemotaxis	IEA Inferred from Electronic Annotation more info
immune response	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
viral reproduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-C motif chemokine 1

Names: C-C motif chemokine 1; inflammatory cytokine I-309; small-inducible cytokine A1; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002981.1 → NP_002972.1 C-C motif chemokine 1 precursor

Status: REVIEWED

Source sequence(s)

M57502, M57506

Consensus CDS

CCDS11282.1

UniProtKB/Swiss-Prot

P22362

Related

ENSP00000225842, OTTHUMP00000163800, ENST00000225842, OTTHUMT00000256385

Conserved Domains (1) summary

cd00272
Location:33 – 89
Blast Score: 170

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

32687399..32690252, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

28873463..28876185, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

32749570..32752425, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB110829.1	BAC98367.1
genomic	ABBA01011215.1	None
genomic	AC011193.3 (127123..129976)	None
genomic	AMYH01008350.1 (319752..322607)	None
genomic	CH471147.2	EAW80204.1
genomic	HI574344.1	CBX47661.1
genomic	M57506.1	AAA52705.1
mRNA	AK312183.1	BAG35116.1
mRNA	BC105073.1	AAI05074.1
mRNA	BC105075.1	AAI05076.1
mRNA	M57502.1	AAA61196.1
other-genetic	BC111914.1	AAI11915.1