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CCL1 chemokine (C-C motif) ligand 1 [ Homo sapiens (human) ]

Gene ID: 6346, updated on 18-Oct-2014
Official Symbol
CCL1provided by HGNC
Official Full Name
chemokine (C-C motif) ligand 1provided by HGNC
Primary source
HGNC:HGNC:10609
See related
Ensembl:ENSG00000108702; HPRD:01654; MIM:182281; Vega:OTTHUMG00000132888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P500; SISe; TCA3; I-309; SCYA1
Summary
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
See CCL1 in Epigenomics, MapViewer
Location:
17q12
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (34360328..34363233, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (32687347..32690252, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) ligand 8 Neighboring gene chemokine (C-C motif) ligand 13 Neighboring gene chromosome 17 open reading frame 102 Neighboring gene transmembrane protein 132E

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat inhibits I-309 (CCL1) driven cell migration as demonstrated using Tat peptides containing CXC or CC-like sequences (Tat amino acids 25-27 and 30-31, respectively) PubMed
Vif vif HIV-1 Vif downregulates the expression of chemokine (C-C motif) ligand 1 (CCL1) in Vif-expression T cells PubMed
Vpr vpr HIV-1 Vpr downregulates the monocyte chemoattractant I-309) PubMed

Go to the HIV-1, Human Interaction Database

  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
C-C motif chemokine 1
Names
C-C motif chemokine 1
inflammatory cytokine I-309
T lymphocyte-secreted protein I-309
small inducible cytokine A1 (I-309, homologous to mouse Tca-3)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002981.2NP_002972.1  C-C motif chemokine 1 precursor

    See proteins identical to NP_002972.1

    Status: REVIEWED

    Source sequence(s)
    AC011193, DA620119, M57502
    Consensus CDS
    CCDS11282.1
    UniProtKB/Swiss-Prot
    P22362
    Related
    ENSP00000225842, OTTHUMP00000163800, ENST00000225842, OTTHUMT00000256385
    Conserved Domains (1) summary
    cd00272
    Location:3389
    Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    34360328..34363233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    28873463..28876185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    32751611..32754516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)