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SCNN1G sodium channel, non-voltage-gated 1, gamma subunit [ Homo sapiens (human) ]

Gene ID: 6340, updated on 16-Apr-2014
Official Symbol
SCNN1Gprovided by HGNC
Official Full Name
sodium channel, non-voltage-gated 1, gamma subunitprovided by HGNC
Primary source
HGNC:10602
See related
Ensembl:ENSG00000166828; HPRD:02862; MIM:600761; Vega:OTTHUMG00000131609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHA1; BESC3; ENaCg; SCNEG; ENaCgamma
Summary
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
Location :
16p12
Sequence :
Chromosome: 16; NC_000016.10 (23182719..23216880)
See SCNN1G in Epigenomics, MapViewer

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 2 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene sodium channel, non-voltage-gated 1, beta subunit Neighboring gene component of oligomeric golgi complex 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
    Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
  • Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
    Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ligand-gated sodium channel activity IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
excretion TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
multicellular organismal water homeostasis IDA
Inferred from Direct Assay
more info
 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
sodium ion homeostasis IDA
Inferred from Direct Assay
more info
 
sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 
sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sodium channel complex IDA
Inferred from Direct Assay
more info
 
Preferred Names
amiloride-sensitive sodium channel subunit gamma
Names
amiloride-sensitive sodium channel subunit gamma
gamma-ENaC
gamma-NaCH
ENaC gamma subunit
epithelial Na(+) channel subunit gamma
sodium channel, nonvoltage-gated 1, gamma
nonvoltage-gated sodium channel 1 subunit gamma
amiloride-sensitive sodium channel gamma-subunit
amiloride-sensitive epithelial sodium channel gamma subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011909.1 RefSeqGene

    Range
    5001..39161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039.3NP_001030.2  amiloride-sensitive sodium channel subunit gamma

    See proteins identical to NP_001030.2

    Status: REVIEWED

    Source sequence(s)
    BC059391, X87160
    Consensus CDS
    CCDS10608.1
    UniProtKB/TrEMBL
    A5X2V1
    UniProtKB/Swiss-Prot
    P51170
    Related
    ENSP00000300061, OTTHUMP00000162369, ENST00000300061, OTTHUMT00000254496
    Conserved Domains (2) summary
    TIGR00859
    Location:24630
    Blast Score: 2395
    ENaC; sodium channel transporter
    TIGR00867
    Location:32551
    Blast Score: 585
    deg-1; degenerin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10

    Range
    23182719..23216880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255469.1XP_005255526.1  

    Conserved Domains (2) summary
    TIGR00859
    Location:24597
    Blast Score: 2203
    ENaC; sodium channel transporter
    TIGR00867
    Location:32518
    Blast Score: 491
    deg-1; degenerin

Alternate HuRef

Genomic

  1. AC_000148.1 Alternate HuRef

    Range
    21283200..21317389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    24204072..24239947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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