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SCNN1B sodium channel, non-voltage-gated 1, beta subunit [ Homo sapiens (human) ]

Gene ID: 6338, updated on 27-Sep-2014
Official Symbol
SCNN1Bprovided by HGNC
Official Full Name
sodium channel, non-voltage-gated 1, beta subunitprovided by HGNC
Primary source
HGNC:HGNC:10600
Locus tag
hCG_23853
See related
Ensembl:ENSG00000168447; HPRD:02861; MIM:600760; Vega:OTTHUMG00000131608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BESC1; ENaCb; SCNEB; ENaCbeta
Summary
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]
See SCNN1B in Epigenomics, MapViewer
Location:
16p12.2-p12.1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (23302270..23381299)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23313591..23392620)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 31 Neighboring gene sodium channel, non-voltage-gated 1, gamma subunit Neighboring gene component of oligomeric golgi complex 7 Neighboring gene cyclin Y-like 1 pseudogene Neighboring gene golgi-associated, gamma adaptin ear containing, ARF binding protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
    Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
  • Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
    Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ligand-gated sodium channel activity IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
excretion TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
multicellular organismal water homeostasis IDA
Inferred from Direct Assay
more info
 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
sodium ion homeostasis IDA
Inferred from Direct Assay
more info
 
sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 
sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sodium channel complex IDA
Inferred from Direct Assay
more info
 
Preferred Names
amiloride-sensitive sodium channel subunit beta
Names
amiloride-sensitive sodium channel subunit beta
beta-ENaC
beta-NaCH
epithelial Na(+) channel subunit beta
epithelial sodium channel beta-2 subunit
epithelial sodium channel beta-3 subunit
sodium channel, nonvoltage-gated 1, beta
nasal epithelial sodium channel beta subunit
nonvoltage-gated sodium channel 1 subunit beta
amiloride-sensitive sodium channel subunit beta 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011908.1 

    Range
    5001..84030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000336.2NP_000327.2  amiloride-sensitive sodium channel subunit beta

    See proteins identical to NP_000327.2

    Status: REVIEWED

    Source sequence(s)
    AU105979, BC036352, L36593
    Consensus CDS
    CCDS10609.1
    UniProtKB/TrEMBL
    B2R812
    UniProtKB/Swiss-Prot
    P51168
    Related
    ENSP00000345751, OTTHUMP00000162368, ENST00000343070, OTTHUMT00000254495
    Conserved Domains (2) summary
    TIGR00859
    Location:21623
    ENaC; sodium channel transporter
    TIGR00867
    Location:29540
    deg-1; degenerin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    23302270..23381299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255467.1XP_005255524.1  

    See proteins identical to XP_005255524.1

    UniProtKB/Swiss-Prot
    P51168
    Related
    ENSP00000302874, OTTHUMP00000255615, ENST00000307331, OTTHUMT00000434810
    Conserved Domains (2) summary
    TIGR00859
    Location:66668
    ENaC; sodium channel transporter
    TIGR00867
    Location:74585
    deg-1; degenerin

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    21402990..21480744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    24325334..24404340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)