BGN biglycan [Homo sapiens] - Gene

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Summary

Official Symbol: BGNprovided by HGNC
Official Full Name: biglycanprovided by HGNC
Primary source: HGNC:1044
See related: Ensembl:ENSG00000182492; HPRD:02359; MIM:301870; Vega:OTTHUMG00000024205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PGI; DSPG1; PG-S1; SLRR1A
Summary: The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]

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Genomic context

Location :: Xq28

Sequence :: Chromosome: X; NC_000023.10 (152760347..152775004)

See BGN in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings demonstrate that Akt is a downstream signalling component of TGF-beta-mediated biglycan core protein synthesis but not glycosaminoglycan chain hyperelongation in vascular smooth muscle
Title: TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle.
Data revealed a strong induction of several genes encoding components of the extracellular matrix, such as collagens, COMP, IGFBP5 and biglycan.
Title: Fibrotic response in fibroblasts from congenital disorders of glycosylation.
This study demonstrates that elevated expression of biglycan may play an important role in the development and progression of gastric cancer, and could be further evaluated as a biomarker for predication of a poor clinical outcome.
Title: Biglycan expression correlates with aggressiveness and poor prognosis of gastric cancer.
Immunoprecipitation analysis revealed that biglycan interacts with both the canonical Wnt ligand Wnt3a and the Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6), possibly via the formation of a trimeric complex.
Title: Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.
Biglycan and decorin reduced the proliferation of pre-adipocytes, partly by induction of apoptosis. Furthermore, the anti-proliferative capabilities of decorin and biglycan were nullified with removal of GAG side-chains.
Title: Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin.
Differential expression of 4 out of 5 genes related to estrogen metabolism and action (ESR1, ESR2, PGR and BGN) was confirmed in endometriosis.
Title: Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.
Biglycan impinges on the expression of total epidermal growth factor receptor and possibly, on the cell-surface expression of the receptors, playing a critical role in the regulation of chondrocyte and pericellular matrix homeostasis.
Title: Biglycan regulates the expression of EGF receptors through EGF signaling pathways in human articular chondrocytes.
expressed decreased in fetal growth restriction placentae
Title: Placental biglycan expression is decreased in human idiopathic fetal growth restriction.
Data show that biglycan (BGN) induces of phospholipid transfer protein (PLTP) in aortic valve interstitial cells via stimulation of Toll-like receptor 2, so increased BGN in stenotic valves contributes to the production of PLTP via TLR 2.
Title: Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2.
study shows (1) a detailed description of ectopic ossification (EO) formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function.
Title: Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance.

Submit: New GeneRIF Correction See all (38)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001702.1		CHRD	BIND	PubMed	BGN (hBgn) interacts with an unspecified isoform of CHRD (Chd). This interaction was modeled on a demonstrated interaction between human BGN and CHRD from an unspecified species.
NP_001702.1			BIND	PubMed	BGN (hBgn) interacts with BMP4/BMP4. This interaction was modeled on a demonstrated interaction between human BGN and BMP4/BMP4 from an unspecified species.
P21810	P04114	APOB	HPRD	PubMed
P21810	P05067	APP	HPRD	PubMed
P21810	P12644	BMP4	HPRD	PubMed
P21810	P02452	COL1A1	HPRD	PubMed
P21810	P08123	COL1A2	HPRD	PubMed
P21810	P02458	COL2A1	HPRD	PubMed
P21810	P08572	COL4A2	HPRD	PubMed
P21810	Q14118	DAG1	HPRD	PubMed
P21810	P15502	ELN	HPRD	PubMed
P21810	P55001	MFAP2	HPRD	PubMed
P21810	P04054	PLA2G1B	HPRD	PubMed
P21810	P01137	TGFB1	HPRD	PubMed
P21810	P01375	TNF	HPRD	PubMed
P21810	O95388	WISP1	HPRD	PubMed
BioGRID:107102	BioGRID:106835	APOB	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:108321	ELN	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:119758	HLN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:121492	JPH3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:110395	MFAP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:112340	SGCA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107102	BioGRID:112898	TGFB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107102	BioGRID:112979	TNF	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
extracellular matrix binding	IEA Inferred from Electronic Annotation more info
extracellular matrix structural constituent	NAS Non-traceable Author Statement more info	PubMed
glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info
blood vessel remodeling	IEA Inferred from Electronic Annotation more info
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
extracellular region	IEA Inferred from Electronic Annotation more info
intracellular part	IEA Inferred from Electronic Annotation more info
proteinaceous extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
sarcolemma	IEA Inferred from Electronic Annotation more info
transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: biglycan

Names: biglycan; biglycan proteoglycan; bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; small leucine-rich protein 1A; dermatan sulphate proteoglycan I

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015961.1 RefSeqGene

Range

4937..19594

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001711.4 → NP_001702.1 biglycan preproprotein

Status: REVIEWED

Source sequence(s)

AI538325, AI570205, BC002416, DC299956, DC419932, DC425011

Consensus CDS

CCDS14721.1

UniProtKB/Swiss-Prot

P21810

Related

ENSP00000327336, OTTHUMP00000025928, ENST00000331595, OTTHUMT00000060981

Conserved Domains (3) summary

cl15309
Location:95 – 321
Blast Score: 105

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam13855
Location:93 – 150
Blast Score: 130

LRR_8; Leucine rich repeat

cl02423
Location:62 – 94
Blast Score: 140

LRRNT; Leucine rich repeat N-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

152760347..152775004

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

141428414..141433357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	CH471172.2	EAW72861.1
		EAW72862.1
		EAW72863.1
		EAW72864.1
		EAW72865.1
genomic	M65151.1	None
genomic	M65153.1	AAA52287.1
mRNA	AI538325.1	None
mRNA	AI570205.1	None
mRNA	AK092954.1	BAC04007.1
mRNA	AK093023.1	BAG52637.1
mRNA	AK094059.1	BAG52806.1
mRNA	AK222484.1	BAD96204.1
mRNA	AK223302.1	BAD97022.1
mRNA	AK291955.1	BAF84644.1
mRNA	AK293268.1	BAG56798.1
mRNA	AK293289.1	BAG56813.1
mRNA	AK297966.1	BAG60276.1
mRNA	AK298756.1	BAG60898.1
mRNA	AU142113.1	None
mRNA	BC002416.2	AAH02416.1
mRNA	BC004244.1	AAH04244.1
mRNA	BT007323.1	AAP35987.1
mRNA	DC299956.1	None
mRNA	DC419932.1	None
mRNA	DC425011.1	None
mRNA	J04599.1	AAA36009.1
mRNA	U11686.1	AAC50117.1
other-genetic	AM392603.1	CAL37481.1
other-genetic	AM393683.1	CAL38559.1
other-genetic	DQ891898.2	ABM82824.1
other-genetic	DQ895084.2	ABM86010.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
P21810.2	GenPept	UniProtKB/Swiss-Prot:P21810
Q53FI4	GenPept	UniProtKB/TrEMBL:Q53FI4
Q53HU6	GenPept	UniProtKB/TrEMBL:Q53HU6
Q8NAB7	GenPept	UniProtKB/TrEMBL:Q8NAB7