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SCD stearoyl-CoA desaturase [ Homo sapiens (human) ]

Gene ID: 6319, updated on 22-May-2016
Official Symbol
SCDprovided by HGNC
Official Full Name
stearoyl-CoA desaturaseprovided by HGNC
Primary source
HGNC:HGNC:10571
See related
Ensembl:ENSG00000099194 HPRD:04941; MIM:604031; Vega:OTTHUMG00000018906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCD1; FADS5; SCDOS; hSCD1; MSTP008
Summary
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
Orthologs
Location:
10q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (100347015..100364831)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102106772..102124588)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 2 Neighboring gene polycystin 2 like 1, transient receptor potential cation channel Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene uncharacterized LOC105378452 Neighboring gene Wnt family member 8B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of stearoyl-CoA desaturase (delta-9-desaturase; SCD) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Activation of gene expression by SREBF (SREBP), organism-specific biosystem (from REACTOME)
    Activation of gene expression by SREBF (SREBP), organism-specific biosystemAfter transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Biosynthesis of unsaturated fatty acids, organism-specific biosystem (from KEGG)
    Biosynthesis of unsaturated fatty acids, organism-specific biosystem
    Biosynthesis of unsaturated fatty acids
  • Biosynthesis of unsaturated fatty acids, conserved biosystem (from KEGG)
    Biosynthesis of unsaturated fatty acids, conserved biosystem
    Biosynthesis of unsaturated fatty acids
  • Fatty Acid Biosynthesis, organism-specific biosystem (from WikiPathways)
    Fatty Acid Biosynthesis, organism-specific biosystem
    Fatty Acid Biosynthesis
  • Fatty Acyl-CoA Biosynthesis, organism-specific biosystem (from REACTOME)
    Fatty Acyl-CoA Biosynthesis, organism-specific biosystemFatty acyl-CoA biosynthesis involves following steps: -Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase-Conversion of palmitic acid to long chain fatty acids and-Conver...
  • Fatty acid metabolism, organism-specific biosystem (from KEGG)
    Fatty acid metabolism, organism-specific biosystem
    Fatty acid metabolism
  • Fatty acid metabolism, conserved biosystem (from KEGG)
    Fatty acid metabolism, conserved biosystem
    Fatty acid metabolism
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
    Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystemSterol regulatory element binding proteins (SREBPs, SREBFs) respond to low cholesterol concentrations by transiting to the nucleus and activating genes involved in cholesterol and lipid biosynthesis ...
  • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
    SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders N??r.
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
    Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...
  • oleate biosynthesis, organism-specific biosystem (from BIOCYC)
    oleate biosynthesis, organism-specific biosystem: OLEATE-CPD (oleic acid) is a monounsaturated fatty acid that makes up 55-80% of olive oil (although the free acid may consist only 0.5-2.5%) and 15-20% of grape seed oil and sea buckthorn oil. Ole...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
stearoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
PubMed 
stearoyl-CoA 9-desaturase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
acyl-CoA desaturase
Names
delta(9)-desaturase
delta-9 desaturase
delta-9-desaturase
fatty acid desaturase
predicted protein of HQ0998
stearoyl-CoA desaturase (delta-9-desaturase)
stearoyl-CoA desaturase opposite strand
NP_005054.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005063.4NP_005054.3  acyl-CoA desaturase

    See identical proteins and their annotated locations for NP_005054.3

    Status: REVIEWED

    Source sequence(s)
    AI761929, AK312312, AL139819, BC062303, DB045963
    Consensus CDS
    CCDS7493.1
    UniProtKB/Swiss-Prot
    O00767
    Related
    ENSP00000359380, OTTHUMP00000020279, ENST00000370355, OTTHUMT00000049857
    Conserved Domains (1) summary
    cd03505
    Location:100337
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    100347015..100364831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    102391212..102409039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)