Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    SATB1 SATB homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 6304, updated on 12-May-2013
    Official Symbol
    SATB1provided by HGNC
    Official Full Name
    SATB homeobox 1provided by HGNC
    Primary source
    HGNC:10541
    See related
    HPRD:03647; MIM:602075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
    Location :
    3p23
    Sequence :
    Chromosome: 3; NC_000003.11 (18389133..18480265, complement)
    See SATB1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene phosducin-like 3 pseudogene 3 Neighboring gene uncharacterized LOC339862 Neighboring gene RAD23 homolog B (S. cerevisiae) pseudogene 1 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 8 Neighboring gene microRNA 4791

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer. Nodin B, et al. Diagn Pathol, 2012 Aug 30. PMID 22935204.
    2. Regulation of DNA replication timing on human chromosome by a cell-type specific DNA binding protein SATB1. Oda M, et al. PLoS One, 2012. PMID 22879953.
    3. Correlation of SATB1 expression with clinical course of cutaneous T-cell lymphomas. Grzanka A, et al. Pol J Pathol, 2012 Jun. PMID 22864778.
    4. Upregulation of SATB1 is associated with the development and progression of glioma. Chu SH, et al. J Transl Med, 2012 Jul 28. PMID 22839214.
    5. SATB1-mediated functional packaging of chromatin into loops. Kohwi-Shigematsu T, et al. Methods, 2012 Nov. PMID 22782115.

    See all (68) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. SATB1 expression is a factor of poor prognosis in colorectal cancer.
      Title: Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer.
    2. Genome wide mapping of SATB1 binding sites and chromatin packaging. [Review]
      Title: SATB1-mediated functional packaging of chromatin into loops.
    3. SATB1 expression seems to be a potential prognosis factor confirming the inner heterogeneous features of Cutaneous T-cell lymphomas
      Title: Correlation of SATB1 expression with clinical course of cutaneous T-cell lymphomas.
    4. SATB1 mRNA expression is associated with the postoperative recurrence and metastasis of hepatocellular carcinoma.
      Title: [Expression of special AT-rich sequence-binding protein 1 mRNA in hepatocellular carcinoma and its clinical significance].
    5. Studies indicate that the regulation of the activity of SATB1 has a critical role in driving two important differentiation pathways in T cells.
      Title: Chromatin organizer SATB1 is an important determinant of T-cell differentiation.
    6. SATB1 may have an important role as a positive regulator of glioma development and progression, and that SATB1 might be a useful molecular marker for predicting the prognosis of glioma
      Title: Upregulation of SATB1 is associated with the development and progression of glioma.
    7. These results reveal a novel role of SATB1 in cell type-specific regulation of replication timing along the chromosome.
      Title: Regulation of DNA replication timing on human chromosome by a cell-type specific DNA binding protein SATB1.
    8. The expression of SATB1 was high in human hepatocellular carcinoma tissue and liver cancer cell lines with high metastatic potential. SATB1 promoted cell cycle progression and cell proliferation and prevented apoptosis.
      Title: Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer.
    9. miR-191 overexpression is sufficient to induce senescence in HEKn cells and that the direct targets, involved in this process, are the Special AT-rich Binding protein 1 (SATB1) and the Cyclin Dependent Kinase 6 (CDK6) mRNAs.
      Title: MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation.
    10. SATB1 may play an important role in the progression of human rectal cancer.
      Title: Correlation of SATB1 overexpression with the progression of human rectal cancer.
    Submit: New GeneRIF Correction See all (46)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q01826 Q9NRL2 BAZ1A    HPRD  PubMed  
    Q01826 P55212 CASP6    HPRD  PubMed  
    Q01826 Q12873 CHD3    HPRD  PubMed  
    Q01826 P39880 CUX1    HPRD  PubMed  
    Q01826 Q09472 EP300    HPRD  PubMed  
    Q01826 P23771 GATA3    HPRD  PubMed  
    Q01826 Q13547 HDAC1    HPRD  PubMed  
    Q01826 Q92831 KAT2B    HPRD  PubMed  
    Q01826 O94776 MTA2    HPRD  PubMed  
    Q01826 P52435 POLR2J    HPRD  PubMed  
    Q01826 Q01826 SATB1    HPRD  PubMed  
    Q01826 O60264 SMARCA5    HPRD  PubMed  
    Q01826 P63279 UBE2I    HPRD  PubMed  
    BioGRID:112211 BioGRID:116347 BAZ1A    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
    BioGRID:112211 BioGRID:107289 CASP6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112211 BioGRID:114105 CBX4    BioGRID  PubMed Two-hybrid 
    BioGRID:112211 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:112211 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112211 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112211 BioGRID:107903 CUX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112211 BioGRID:119132 DYT10    BioGRID  PubMed Biochemical Activity 
    BioGRID:112211 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:112211 BioGRID:109316 HDAC2    BioGRID  PubMed Co-fractionation 
    BioGRID:112211 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:112211 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:112211 BioGRID:114124 PIAS1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:112211 BioGRID:115673 PIAS3    BioGRID  PubMed Two-hybrid 
    BioGRID:112211 BioGRID:119624 PIAS4    BioGRID  PubMed Two-hybrid 
    BioGRID:112211 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112211 BioGRID:111435 POLR2J    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112211 BioGRID:117439 SIN3A    BioGRID  PubMed Co-fractionation 
    BioGRID:112211 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:112211 BioGRID:114045 SMARCA5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112211 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:112211 BioGRID:112496 SUMO3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112211 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112211 BioGRID:115505 TOPORS    BioGRID  PubMed Two-hybrid 
    BioGRID:112211 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112211 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:112211 BioGRID:119501 UBR5    BioGRID  PubMed Two-hybrid 
    BioGRID:112211 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-stranded DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    CD4-positive, alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    CD8-positive, alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular component disassembly involved in execution phase of apoptosis TAS
    Traceable Author Statement
    more info
    		  
    chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    epidermis development IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    reflex IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear heterochromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    DNA-binding protein SATB1
    Names
    DNA-binding protein SATB1
    special AT-rich sequence-binding protein 1
    special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027814.1 RefSeqGene

      Range
      5001..96133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001131010.2 → NP_001124482.1  DNA-binding protein SATB1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 3. Isoform 1 has a shorter C-terminus, compared to isoform 2.
      Source sequence(s)
      AA001621, AK127242, BC001744, DA938384, DB141938
      Consensus CDS
      CCDS2631.1
      UniProtKB/Swiss-Prot
      Q01826
      Conserved Domains (3) summary
      cd00086
      Location:646 – 704
      Blast Score: 108
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam02376
      Location:363 – 448
      Blast Score: 281
      CUT; CUT domain
      cd11585
      Location:74 – 169
      Blast Score: 426
      SATB1_N; N-terminal domain of SATB1 and similar proteins

    2. NM_001195470.1 → NP_001182399.1  DNA-binding protein SATB1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AA001621, AB209761, AC144521, AK127242, DA938384
      Consensus CDS
      CCDS56242.1
      UniProtKB/Swiss-Prot
      Q01826
      Conserved Domains (3) summary
      cd00086
      Location:678 – 736
      Blast Score: 108
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam02376
      Location:363 – 448
      Blast Score: 281
      CUT; CUT domain
      cd11585
      Location:74 – 169
      Blast Score: 426
      SATB1_N; N-terminal domain of SATB1 and similar proteins

    3. NM_002971.4 → NP_002962.1  DNA-binding protein SATB1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 3. Isoform 1 has a shorter C-terminus, compared to isoform 2.
      Source sequence(s)
      AA001621, AB209761, AC144521, AK127242, BC001744, DA938384
      Consensus CDS
      CCDS2631.1
      UniProtKB/Swiss-Prot
      Q01826
      Conserved Domains (3) summary
      cd00086
      Location:646 – 704
      Blast Score: 108
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam02376
      Location:363 – 448
      Blast Score: 281
      CUT; CUT domain
      cd11585
      Location:74 – 169
      Blast Score: 426
      SATB1_N; N-terminal domain of SATB1 and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p10 Primary Assembly

      Range
      18389133..18480265, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      18323695..18414820, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018914.1 Alternate CHM1_1.0

      Range
      18325478..18416599, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01025116.1 (6106..97231) None
    genomic AC139618.3 (127873..140884) None
    genomic AC144521.9 (48930..111928) None
    genomic AMYH01013008.1 (602967..694088) None
    genomic CH471055.1 EAW64291.1
      EAW64292.1
      EAW64293.1
    genomic GN344109.1 CAY55990.1
    genomic HI589661.1 CBX55095.1
    mRNA AA001621.1 None
    mRNA AB209761.1 BAD92998.1
    mRNA AK127242.1 BAG54463.1
    mRNA AU127749.1 None
    mRNA BC001744.1 AAH01744.1
    mRNA BE218845.1 None
    mRNA BI494258.1 None
    mRNA CD677701.1 None
    mRNA DA938384.1 None
    mRNA DB134320.1 None
    mRNA DB141938.1 None
    mRNA M97287.1 AAA60304.1
    mRNA U92993.1 None
    other-genetic DQ891870.2 ABM82796.1
    other-genetic DQ895058.2 ABM85984.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01826.1 GenPept UniProtKB/Swiss-Prot:Q01826

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...