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SAT1 spermidine/spermine N1-acetyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 6303, updated on 13-Jan-2015
Official Symbol
SAT1provided by HGNC
Official Full Name
spermidine/spermine N1-acetyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:10540
See related
Ensembl:ENSG00000130066; HPRD:02431; MIM:313020; Vega:OTTHUMG00000021256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1
Summary
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
Orthologs
See SAT1 in MapViewer
Location:
Xp22.1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) X NC_000023.11 (23783158..23786210)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (23801275..23804327)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 4 Neighboring gene acyl-CoA thioesterase 9 Neighboring gene ribosomal protein L9 pseudogene 7 Neighboring gene apolipoprotein O Neighboring gene chromosome X open reading frame 58

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Spermidine N1-acetyltransferase, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vif vif It is postulated that HIV-1 Vif modulates SSAT activity, affecting levels of cellular polyamines leading to possible effects on the properties of viral RNA PubMed
vif Binding of HIV-1 Vif to SSAT was identified using a yeast two-hybrid screen and confirmed by co-immunoprecipitation PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ17136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
diamine N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
spermidine binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
polyamine biosynthetic process TAS
Traceable Author Statement
more info
 
polyamine metabolic process TAS
Traceable Author Statement
more info
 
putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
spermidine acetylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
Preferred Names
diamine acetyltransferase 1
Names
diamine acetyltransferase 1
putrescine acetyltransferase
diamine N-acetyltransferase 1
polyamine N-acetyltransferase 1
spermidine/spermine N1-acetyltransferase alpha
NP_002961.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012929.1 

    Range
    5001..8066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002970.3NP_002961.1  diamine acetyltransferase 1

    See proteins identical to NP_002961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein coding transcript.
    Source sequence(s)
    AW874291, BC008424, CN271682
    Consensus CDS
    CCDS14207.1
    UniProtKB/Swiss-Prot
    P21673
    UniProtKB/TrEMBL
    Q6ICU9
    Related
    ENSP00000368572, OTTHUMP00000023061, ENST00000379270, OTTHUMT00000056056
    Conserved Domains (2) summary
    cd04301
    Location:54126
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    COG0456
    Location:1144
    RimI; Acetyltransferases [General function prediction only]

RNA

  1. NR_027783.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL050290, AW874291, CD516700

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000023.11 

    Range
    23783158..23786210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 

    Range
    23832183..23835235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000155.1 

    Range
    21540756..21543811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)