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    SLC22A23 solute carrier family 22, member 23 [ Homo sapiens ]

    Gene ID: 63027, updated on 11-May-2012

    Summary

    Official Symbol
    SLC22A23provided by HGNC
    Official Full Name
    solute carrier family 22, member 23provided by HGNC
    Primary source
    HGNC:21106
    Locus tag
    RP11-506K6.2
    See related
    Ensembl:ENSG00000137266; HPRD:12904; MIM:611697; Vega:OTTHUMG00000014144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf85; FLJ22174; DKFZp434F011
    Summary
    SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

    Genomic context

    Location :
    6p25.2
    Sequence :
    Chromosome: 6; NC_000006.11 (3269207..3456793, complement)
    See SLC22A23 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507294 Neighboring gene tubulin, beta 2B class IIb Neighboring gene proteasome (prosome, macropain) assembly chaperone 4 Neighboring gene uncharacterized LOC643327 Neighboring gene translocase of outer mitochondrial membrane 5 homolog (yeast) pseudogene Neighboring gene PX domain containing 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121960 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 23
    Names
    solute carrier family 22 member 23
    ion transporter protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015482.1NP_056297.1  solute carrier family 22 member 23 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AJ420525, AK172770, AK308943, AL160398, BC040876, BC128580
      Consensus CDS
      CCDS47363.1
      UniProtKB/Swiss-Prot
      A1A5C7
      Related
      ENSP00000385028, OTTHUMP00000213939, ENST00000406686, OTTHUMT00000353059
      Conserved Domains (2) summary
      cd06174
      Location:235364
      Blast Score: 126
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:93429
      Blast Score: 338
      2A0119; cation transport protein
    2. NM_021945.5NP_068764.3  solute carrier family 22 member 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      AJ420525, AK172770, AL445309, BC038748
      Consensus CDS
      CCDS34331.1
      UniProtKB/Swiss-Prot
      A1A5C7
      Related
      ENSP00000419463, OTTHUMP00000213940, ENST00000490273, OTTHUMT00000039686
      Conserved Domains (1) summary
      TIGR00898
      Location:1148
      Blast Score: 216
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      3269207..3456793, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      3147050..3335140, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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