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S100A9 S100 calcium binding protein A9 [ Homo sapiens (human) ]

Gene ID: 6280, updated on 22-May-2016
Official Symbol
S100A9provided by HGNC
Official Full Name
S100 calcium binding protein A9provided by HGNC
Primary source
HGNC:HGNC:10499
See related
Ensembl:ENSG00000163220 HPRD:00472; MIM:123886; Vega:OTTHUMG00000013125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]
Orthologs
Location:
1q21
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (153357854..153361027)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153330330..153333503)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidoglycan recognition protein 3 Neighboring gene peptidoglycan recognition protein 4 Neighboring gene S100 calcium binding protein A12 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RAGE receptor binding TAS
Traceable Author Statement
more info
PubMed 
Toll-like receptor 4 binding TAS
Traceable Author Statement
more info
PubMed 
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
autophagy IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
chemokine production TAS
Traceable Author Statement
more info
PubMed 
cytokine production TAS
Traceable Author Statement
more info
PubMed 
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil aggregation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-cysteine S-trans-nitrosylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of integrin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
sequestering of zinc ion TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
protein S100-A9
Names
MRP-14
S100 calcium-binding protein A9 (calgranulin B)
calgranulin B
calgranulin-B
calprotectin L1H subunit
leukocyte L1 complex heavy chain
migration inhibitory factor-related protein 14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002965.3NP_002956.1  protein S100-A9

    See identical proteins and their annotated locations for NP_002956.1

    Status: REVIEWED

    Source sequence(s)
    AF086362, BC047681, X06233
    Consensus CDS
    CCDS1036.1
    UniProtKB/Swiss-Prot
    P06702
    Related
    ENSP00000357727, OTTHUMP00000015331, ENST00000368738, OTTHUMT00000036793
    Conserved Domains (2) summary
    cd05030
    Location:694
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:3180
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    153357854..153361027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    154726043..154729216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)