BDNF brain-derived neurotrophic factor [Homo sapiens (human)] - Gene

Summary

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Official Symbol: BDNFprovided by HGNC
Official Full Name: brain-derived neurotrophic factorprovided by HGNC
Primary source: HGNC:1033
See related: Ensembl:ENSG00000176697; HPRD:00214; MIM:113505; Vega:OTTHUMG00000178797
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANON2; BULN2
Summary: The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]

Genomic context

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Location :: 11p13

Sequence :: Chromosome: 11; NC_000011.9 (27676440..27743605, complement)

See BDNF in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight
Title: Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
The interactions of BDNF with neurotrophic tyrosine kinase receptor type (NTRK)2 gene likely play an essential role in the development of treatment-resistant depression in Han Chinese patients.
Title: The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.
Results showed a negative correlation between the natural log of plasma BDNF concentrations and various psychopathological traits in a healthy sample population.
Title: Do levels of brain-derived neurotrophic factor (BDNF) in plasma correlate with psychopathology in healthy subjects?
There was a positive correlation between maternal overprotection and serum BDNF only in Met carriers.
Title: Associations between parenting behavior and anxiety in a rodent model and a clinical sample: relationship to peripheral BDNF levels.
The BDNF-TrkB-ERK1/2 pathway is a proproliferative signaling pathway for pulmonary arterial smooth muscle cell in pulmonary hypertension.
Title: BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.
No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
Title: No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
This review discusses the BDNF Val66Met polymorphism which occurs and has been previously implicated in Alzheimer's disease.
Title: Missense substitutions associated with behavioural disturbances in Alzheimer's disease (AD).
The present study aims to examine the association between three common BDNF single-nucleotid polymorphisms (SNPs; rs7103411, rs7124442, and rs6265) and depressive symptoms in a community-based elderly population.
Title: Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.
Lower serum BDNF levels are associated with poorer neurocognitive performance in patients with major depression. These associations appear in healthy controls as well.
Title: Cognitive functions and serum levels of brain-derived neurotrophic factor in patients with major depressive disorder.
rs12273363 of BDNF does not appear to have functional consequences that would involve its role in bipolar illness.
Title: BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with bipolar disorder.

Submit: New GeneRIF Correction See all (808)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Congenital central hypoventilation

MIM: 209880

Genetic Testing Registry

Summary from GeneReviews: Congenital Central Hypoventilation Syndrome

Congenital central hypoventilation syndrome (CCHS) is characterized by a classic presentation in newborns and a milder later-onset (LO-CCHS) presentation in toddlers, children, and adults. Classic CCHS presents in newborns as (1) apparent hypoventilation with monotonous respiratory rates and shallow breathing either during sleep only or while awake as well as asleep; (2) autonomic nervous system dysregulation (ANSD); and (3) in some individuals, altered development of neural crest-derived structures (i.e., Hirschsprung disease) and/or tumors of neural crest origin (neuroblastoma, ganglioneuroma, and ganglioneuroblastoma). Individuals with CCHS who have been diagnosed early and ventilated conservatively and consistently throughout childhood have reached the age of 20 to 30 years. LO-CCHS manifests as nocturnal alveolar hypoventilation and mild ANSD. Individuals with LO-CCHS who were not identified until age 20 years or older have reached the age of 30 to 55 years.

Diagnosis Testing

Diagnosis of CCHS is established based on (1) clinical findings of alveolar hypoventilation and ANSD in the absence of primary pulmonary, cardiac, or neuromuscular disease, or a causative brain stem lesion that can account for the entire phenotype; and (2) identification of a disease-causing mutation in PHOX2B. Molecular genetic testing of PHOX2B, the only gene in which mutations are known to cause CCHS, is available clinically.

Genetic Counseling

CCHS is inherited in an autosomal dominant manner. Most individuals with CCHS are heterozygous for a de novo PHOX2B mutation; some have an affected parent and 5%-10% have an asymptomatic parent who has mosaicism for a PHOX2B mutation. Each child of an individual with CCHS has a 50% chance of inheriting the PHOX2B mutation; the risk to the offspring of an individual with mosaicism is 50% or lower. Prenatal testing for pregnancies at increased risk is possible if the causative mutation has been identified in an affected family member.

References

PMID: 20301600

Obsessive-compulsive disorder

MIM: 164230

Genetic Testing Registry

NHGRI GWAS Catalog

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

Genome wide association study identifies KCNMA1 contributing to human obesity.

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

Genome-wide meta-analyses identify multiple loci associated with smoking behavior.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Co-exposure of human fetal neurons to brain-derived neurotrophic factor (BDNF) and HIV-1 gp120 leads to a dose-dependent increase in BDNF-induced somatostatin (SRIF) production	PubMed
Tat, p14	tat	HIV-1 Tat increases proapoptotic proBDNF and decreases the mature BDNF protein in hippocampal neurons	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P23560	P23560	BDNF	HPRD	PubMed
P23560	Q86UW7	CADPS2	HPRD	PubMed
P23560	P16870	CPE	HPRD	PubMed
P23560	P03372	ESR1	HPRD	PubMed
P23560	Q14703	MBTPS1	HPRD	PubMed
P23560	P13591	NCAM1	HPRD	PubMed
P23560	P29474	NOS3	HPRD	PubMed
P23560	P20783	NTF3	HPRD	PubMed
P23560	P34130	NTF4	HPRD	PubMed
P23560	Q16620	NTRK2	HPRD	PubMed
P23560	Q99523	SORT1	HPRD	PubMed
BioGRID:107096	BioGRID:128177	AGO3	BioGRID	PubMed	Two-hybrid
BioGRID:107096	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107096	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:107096	BioGRID:119153	F11R	BioGRID	PubMed	Two-hybrid
BioGRID:107096	BioGRID:119720	INPP5K	BioGRID	PubMed	Two-hybrid
BioGRID:107096	BioGRID:109929	JUNB	BioGRID	PubMed	Two-hybrid
BioGRID:107096	BioGRID:110970	NTRK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107096	BioGRID:247131	Ntrk2	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Alcoholism, organism-specific biosystem (from KEGG)
Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Alcoholism, conserved biosystem (from KEGG)
Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
Cocaine addiction, organism-specific biosystem (from KEGG)
Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
Cocaine addiction, conserved biosystem (from KEGG)
Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
FSH signaling pathway, organism-specific biosystem (from WikiPathways)
FSH signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
Neurotrophic factor-mediated Trk receptor signaling
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
p75(NTR)-mediated signaling, organism-specific biosystem
p75(NTR)-mediated signaling

General gene information

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Markers

BDNF-1 (e-PCR)
- UniSTS:253960

BDNF (e-PCR)
- UniSTS:266531

GDB:197571 (e-PCR)
- UniSTS:155950

BDNF (e-PCR)
- UniSTS:12882

D11S4115 (e-PCR), detects polymorphism
- UniSTS:73352

BDNF_2411 (e-PCR)
- UniSTS:280459

D11S1270 (e-PCR)
- UniSTS:148364

D11S2825 (e-PCR)
- UniSTS:152013

D11S4429 (e-PCR)
- UniSTS:43225

Genotypes

See BDNF SNP Geneview Report
See BDNF SNP Genotype Report
See BDNF SNP Variation Viewer Report

Homology

Homologs of the BDNF gene: The BDNF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Clone Names

MGC34632

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
growth factor activity	IEA Inferred from Electronic Annotation more info
neurotrophin TRKB receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
axon guidance	IEA Inferred from Electronic Annotation more info
axon target recognition	IEA Inferred from Electronic Annotation more info
chronic inflammatory response	IEA Inferred from Electronic Annotation more info
dendrite development	IEA Inferred from Electronic Annotation more info
fear response	IEA Inferred from Electronic Annotation more info
feeding behavior	IEA Inferred from Electronic Annotation more info
glutamate secretion	IEA Inferred from Electronic Annotation more info
inner ear development	IEA Inferred from Electronic Annotation more info
learning or memory	IEA Inferred from Electronic Annotation more info
mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
negative regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of striated muscle tissue development	IEA Inferred from Electronic Annotation more info
nerve development	IEA Inferred from Electronic Annotation more info
nervous system development	TAS Traceable Author Statement more info	PubMed
neuron recognition	IEA Inferred from Electronic Annotation more info
positive regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
regulation of excitatory postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
regulation of metabolic process	IEA Inferred from Electronic Annotation more info
regulation of retinal cell programmed cell death	IEA Inferred from Electronic Annotation more info
regulation of short-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
response to anesthetic	IEA Inferred from Electronic Annotation more info
response to fluoxetine	IEA Inferred from Electronic Annotation more info
response to hormone stimulus	IEA Inferred from Electronic Annotation more info
response to hyperoxia	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to vitamin A	IEA Inferred from Electronic Annotation more info
ureteric bud development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
synaptic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: brain-derived neurotrophic factor

Names: brain-derived neurotrophic factor; abrineurin; neurotrophin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011794.1 RefSeqGene

Range

5001..72164

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001143805.1 → NP_001137277.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (7), also known as IIa or BDNF2A, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674517

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000432035, OTTHUMP00000232006, ENST00000525950, OTTHUMT00000388086

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143806.1 → NP_001137278.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as IIb or BDNF2B, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674518

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000379302, OTTHUMP00000232022, ENST00000395978, OTTHUMT00000388105

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143807.1 → NP_001137279.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (9), also known as III or BDNF3, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674520

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000435805, OTTHUMP00000232021, ENST00000532997, OTTHUMT00000388104

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143808.1 → NP_001137280.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (10), also known as Va, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689011

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000379307, OTTHUMP00000232018, ENST00000395983, OTTHUMT00000388101

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143809.1 → NP_001137281.1 brain-derived neurotrophic factor isoform d preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (17), also known as Vb, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) contains a longer N-terminus compared to isoform a.

Source sequence(s)

EF689012

UniProtKB/Swiss-Prot

P23560

Conserved Domains (1) summary

pfam00243
Location:159 – 276
Blast Score: 569

NGF; Nerve growth factor family
NM_001143810.1 → NP_001137282.1 brain-derived neurotrophic factor isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (18), also known as V-VIII, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (e) contains a longer N-terminus compared to isoform a.

Source sequence(s)

EF689019

Consensus CDS

CCDS44558.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000414303, OTTHUMP00000232019, ENST00000438929, OTTHUMT00000388102

Conserved Domains (1) summary

pfam00243
Location:212 – 329
Blast Score: 578

NGF; Nerve growth factor family
NM_001143811.1 → NP_001137283.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (11), also known as V-VIII-VIIIh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689020

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000389564, ENST00000420794

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143812.1 → NP_001137284.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (12), also known as Vh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

CX751420, EF689013

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000435564, OTTHUMP00000232016, ENST00000530861, OTTHUMT00000388099

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143813.1 → NP_001137285.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (13), also known as VIa, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689014

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000432376, OTTHUMP00000232015, ENST00000533246, OTTHUMT00000388098

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143814.1 → NP_001137286.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (14), also known as VIb-IXbd, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689016

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000400502, OTTHUMP00000232014, ENST00000418212, OTTHUMT00000388097

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001143816.1 → NP_001137288.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (16), also known as IXabd, differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689010

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000389345, OTTHUMP00000232039, ENST00000439476, OTTHUMT00000388134

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_001709.4 → NP_001700.2 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as VIb or BDNF5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689015

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000349084, OTTHUMP00000232013, ENST00000356660, OTTHUMT00000388096

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_170731.4 → NP_733927.1 brain-derived neurotrophic factor isoform b preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as I, BDNF1, or 1-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to isoform a.

Source sequence(s)

EF689021

Consensus CDS

CCDS7865.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000320002, OTTHUMP00000232043, ENST00000314915, OTTHUMT00000388138

Conserved Domains (1) summary

pfam00243
Location:138 – 255
Blast Score: 576

NGF; Nerve growth factor family
NM_170732.4 → NP_733928.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as IIc, BDNF2C, or 2-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674519

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000379305, OTTHUMP00000232005, ENST00000395981, OTTHUMT00000388085

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_170733.3 → NP_733929.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as IV, BDNF4, or 3-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674521

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000379304, ENST00000395980

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family
NM_170734.3 → NP_733930.1 brain-derived neurotrophic factor isoform c preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as VIIb, BDNF6B, or 4I-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) contains a longer N-terminus compared to isoform a.

Source sequence(s)

EF689018

Consensus CDS

CCDS41628.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000379309, OTTHUMP00000232041, ENST00000395986, OTTHUMT00000388136

Conserved Domains (1) summary

pfam00243
Location:145 – 262
Blast Score: 574

NGF; Nerve growth factor family
NM_170735.5 → NP_733931.1 brain-derived neurotrophic factor isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as IX, represents the longest transcript. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF689009

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000437138, OTTHUMP00000232040, ENST00000525528, OTTHUMT00000388135

Conserved Domains (1) summary

pfam00243
Location:130 – 247
Blast Score: 576

NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

27676440..27743605, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

27374586..27441772, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

27604550..27671757, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001143815.1: Suppressed sequence

Description

NM_001143815.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, which contains non-consensus splice sites in the 5' UTR.

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01060968.1 (31777..98963)	None
genomic	AC103796.3 (24037..25213)	None
genomic	AC104563.14 (75521..141200)	None
genomic	AF411339.1	AAO15434.1
genomic	AMYH01003456.1 (1067752..1113360)	None
genomic	AMYH01003457.1	None
genomic	AY011481.1	AAG47514.1
genomic	CH471064.2	EAW68274.1
		EAW68275.1
		EAW68276.1
		EAW68277.1
		EAW68278.1
		EAW68279.1
genomic	M37762.1	AAA51820.1
genomic	M61181.1	AAA96140.1
genomic	X60202.1	None
mRNA	AB038670.1	BAB55545.1
mRNA	AB038671.1	BAB55546.1
mRNA	AB038672.1	BAB55547.1
mRNA	AB038673.1	BAB55548.1
mRNA	AB038674.1	BAB55549.1
mRNA	AF400438.1	AAK92487.1
mRNA	AK289763.1	BAF82452.1
mRNA	AK289853.1	BAF82542.1
mRNA	AY054392.2	AAL23557.2
mRNA	AY054393.2	AAL23558.1
mRNA	AY054394.2	AAL23559.1
mRNA	AY054395.2	AAL23560.1
mRNA	AY054396.2	AAL23561.1
mRNA	AY054397.2	AAL23562.1
mRNA	AY054398.2	AAL23563.1
mRNA	AY054399.2	AAL23564.1
mRNA	AY054400.2	AAL23565.2
mRNA	AY054406.3	AAL23571.2
mRNA	AY442188.1	AAR14686.1
mRNA	AY656701.1	AAT74399.1
mRNA	BC029795.1	AAH29795.1
mRNA	CX751420.1	None
mRNA	DQ250642.1	ABB51155.1
mRNA	EF674517.1	ABS29021.1
mRNA	EF674518.1	ABS29022.1
mRNA	EF674519.1	ABS29023.1
mRNA	EF674520.1	ABS29024.1
mRNA	EF674521.1	ABS29025.1
mRNA	EF689009.1	ABS32249.1
mRNA	EF689010.1	ABS32250.1
mRNA	EF689011.1	ABS32251.1
mRNA	EF689012.1	ABS32252.1
mRNA	EF689013.1	ABS32253.1
mRNA	EF689014.1	ABS32254.1
mRNA	EF689015.1	ABS32255.1
mRNA	EF689016.1	ABS32256.1
mRNA	EF689017.1	ABS32257.1
mRNA	EF689018.1	ABS32258.1
mRNA	EF689019.1	ABS32259.1
mRNA	EF689020.1	ABS32260.1
mRNA	EF689021.1	ABS32261.1
mRNA	M61176.1	AAA69805.2
mRNA	X60201.1	CAA42761.1
mRNA	X91251.1	CAA62632.1
other-genetic	DQ890811.2	ABM81737.1
other-genetic	DQ893966.2	ABM84892.1