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CLIP1 CAP-Gly domain containing linker protein 1 [ Homo sapiens (human) ]

Gene ID: 6249, updated on 8-May-2016
Official Symbol
CLIP1provided by HGNC
Official Full Name
CAP-Gly domain containing linker protein 1provided by HGNC
Primary source
HGNC:HGNC:10461
See related
Ensembl:ENSG00000130779 HPRD:01568; MIM:179838; Vega:OTTHUMG00000168922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSN; CLIP; CYLN1; CLIP170; CLIP-170
Summary
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
Location:
12q24.3
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (122271432..122422632, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122755981..122907179, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101593348 Neighboring gene diablo IAP-binding mitochondrial protein Neighboring gene VPS33A, CORVET/HOPS core subunit Neighboring gene coiled-coil domain containing 150 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 1 Neighboring gene CLIP1 antisense RNA 1 Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene arginine/serine-rich coiled-coil 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
    Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
    Lissencephaly gene (LIS1) in neuronal migration and development
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • RHO GTPases activate IQGAPs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate IQGAPs, organism-specific biosystemIQGAPs constitute a family of scaffolding proteins characterized by a calponin homology (CH) domain, a polyproline binding region (WW domain), a tandem of four IQ (isoleucine and glutamine-rich) repe...
  • Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Microtubule Cytoskeleton, organism-specific biosystem
    Regulation of Microtubule Cytoskeleton
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding NAS
Non-traceable Author Statement
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport into plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
sister chromatid cohesion TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome TAS
Traceable Author Statement
more info
PubMed 
intermediate filament TAS
Traceable Author Statement
more info
PubMed 
kinetochore TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with macropinosome IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule end IDA
Inferred from Direct Assay
more info
 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
CAP-Gly domain-containing linker protein 1
Names
cytoplasmic linker protein 1
cytoplasmic linker protein 170 alpha-2
cytoplasmic linker protein CLIP-170
restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030352.1 RefSeqGene

    Range
    5001..156136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247997.1NP_001234926.1  CAP-Gly domain-containing linker protein 1 isoform c

    See identical proteins and their annotated locations for NP_001234926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC048338, BC126305, CB305431, M97501
    Consensus CDS
    CCDS58285.1
    UniProtKB/Swiss-Prot
    P30622
    Related
    ENSP00000479322, ENST00000620786
    Conserved Domains (2) summary
    pfam01576
    Location:3531186
    Myosin_tail_1; Myosin tail
    pfam01302
    Location:214279
    CAP_GLY; CAP-Gly domain
  2. NM_002956.2NP_002947.1  CAP-Gly domain-containing linker protein 1 isoform a

    See identical proteins and their annotated locations for NP_002947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AK126990, BM998166, M97501, X64838
    Consensus CDS
    CCDS9232.1
    UniProtKB/Swiss-Prot
    P30622
    UniProtKB/TrEMBL
    A0A024RBR1, B3KXA5
    Related
    ENSP00000351665, ENST00000358808
    Conserved Domains (2) summary
    pfam01576
    Location:3531175
    Myosin_tail_1; Myosin tail
    pfam01302
    Location:214279
    CAP_GLY; CAP-Gly domain
  3. NM_198240.1NP_937883.1  CAP-Gly domain-containing linker protein 1 isoform b

    See identical proteins and their annotated locations for NP_937883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AK126990, BM998166, M97501, X64838
    Consensus CDS
    CCDS9233.1
    UniProtKB/Swiss-Prot
    P30622
    UniProtKB/TrEMBL
    B3KXA5
    Related
    ENSP00000445531, OTTHUMP00000239759, ENST00000537178, OTTHUMT00000401620
    Conserved Domains (2) summary
    pfam01576
    Location:3361140
    Myosin_tail_1; Myosin tail
    pfam01302
    Location:214279
    CAP_GLY; CAP-Gly domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    122271432..122422632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719552.2XP_006719615.1  

    Conserved Domains (2) summary
    pfam01576
    Location:3531175
    Myosin_tail_1; Myosin tail
    pfam01302
    Location:214279
    CAP_GLY; CAP-Gly domain
  2. XM_005253593.2XP_005253650.1  

    Conserved Domains (2) summary
    pfam01576
    Location:3531186
    Myosin_tail_1; Myosin tail
    pfam01302
    Location:214279
    CAP_GLY; CAP-Gly domain

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    122724274..122875405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)