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RPS15 ribosomal protein S15 [ Homo sapiens (human) ]

Gene ID: 6209, updated on 8-May-2016
Official Symbol
RPS15provided by HGNC
Official Full Name
ribosomal protein S15provided by HGNC
Primary source
HGNC:HGNC:10388
See related
Ensembl:ENSG00000115268 HPRD:01613; MIM:180535; Vega:OTTHUMG00000140099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIG; S15
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Orthologs
Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (1438364..1440494)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1438363..1440494)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene DAZ associated protein 1 Neighboring gene adenomatosis polyposis coli 2 Neighboring gene chromosome 19 open reading frame 25 Neighboring gene proprotein convertase subtilisin/kexin type 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
40S ribosomal protein S15
Names
homolog of rat insulinoma
insulinoma protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017014.1 RefSeqGene

    Range
    5001..7134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018.4NP_001009.1  40S ribosomal protein S15 isoform 2

    See identical proteins and their annotated locations for NP_001009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BG253776, BU602036, J02984
    Consensus CDS
    CCDS12067.1
    UniProtKB/Swiss-Prot
    P62841
    Related
    ENSP00000467466, OTTHUMP00000263267, ENST00000592588, OTTHUMT00000449609
    Conserved Domains (1) summary
    PTZ00096
    Location:1143
    PTZ00096; 40S ribosomal protein S15; Provisional
  2. NM_001308226.1NP_001295155.1  40S ribosomal protein S15 isoform 1

    See identical proteins and their annotated locations for NP_001295155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BE798984, BG253776, BG705752, BM558707
    Consensus CDS
    CCDS77210.1
    UniProtKB/TrEMBL
    K7ELC2
    Conserved Domains (1) summary
    PTZ00096
    Location:12150
    PTZ00096; 40S ribosomal protein S15; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    1438364..1440494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528176.1XP_011526478.1  

    Related
    ENSP00000466010, OTTHUMP00000263268, ENST00000593052, OTTHUMT00000449613
    Conserved Domains (1) summary
    PTZ00096
    Location:12150
    PTZ00096; 40S ribosomal protein S15; Provisional

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    1438358..1440487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)