RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: RPS6KB1provided by HGNC
Official Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1provided by HGNC
Primary source: HGNC:10436
See related: Ensembl:ENSG00000108443; HPRD:10202; MIM:608938; Vega:OTTHUMG00000150642
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S6K; PS6K; S6K1; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 17q23.1

Sequence :: Chromosome: 17; NC_000017.10 (57970443..58027787)

See RPS6KB1 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockdown of PHLPP1 or PHLPP2 resulted in an increase in S6K1 phosphorylation.
Title: PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth.
Data show that the deregulated kinase activities identified, which include the mTOR/p70S6K and ERK1/2 pathways, are potential novel molecular targets in MM.
Title: Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention.
Studies indicate that the inhibition of mTORC1 by FOXO could lead to the activation of Akt via the inhibition of the negative feedback loop driven by mTORC1 and S6K1.
Title: Interplay between FOXO, TOR, and Akt.
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.
Title: S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.
The observations may have practical implications as they raise the possibility to consider p70S6K and/or S6 as a potential therapeutic target-besides mTOR-in certain lymphomas and perhaps in clinical immunosuppression.
Title: Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein.
phosphorylation of S6K1 is required for mTOR to phosphorylate the hydrophobic motif of S6K1.
Title: Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).
A fusion transcript (RPS6KB1-VMP1) recurrently expressed in 30% of breast cancers is associated with clinical consequences and may indicate genomic instability altering the expression of oncogenic components such as MIR21 and RPS6KB1.
Title: Transcriptional consequences of genomic structural aberrations in breast cancer.
nSMase2 is a major component of ATRA-induced growth arrest of MCF-7 cells; S6K is a novel downstream target of nSMase2
Title: Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase.
Knockdown of SIRT1 abolished GR-induced p16 repression as well as Akt/p70S6K1 activation implying that SIRT1 may affect p16 repression through direct deacetylation effects and indirect regulation of Akt/p70S6K1 signaling.
Title: p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.
Akt2 specifically targets and activates the p70S6K signaling pathway
Title: Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.

Submit: New GeneRIF Correction See all (112)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
AAA36411.1	NP_001001.2	RPS6	BIND	PubMed	RPS6KB1 (S6K1) interacts with and phosphorylates RPS6.
AAA36411.1			BIND	PubMed	The CDC2-CCNB1 (Cdc2-cyclin B) complex interacts with and phosphorylates RPS6KB1 (S6K1).
NP_003152.1			BIND	PubMed	mTOR-Rheb complex phosphorylates RPS6KB1 (p70S6K).
P23443	P31749	AKT1	HPRD	PubMed
P23443	P60953	CDC42	HPRD	PubMed
P23443	P06493	CDK1	HPRD	PubMed
P23443	Q13057	COASY	HPRD	PubMed
P23443	P67870	CSNK2B	HPRD	PubMed
P23443	O00418	EEF2K	HPRD	PubMed
P23443	P23588	EIF4B	HPRD	PubMed
P23443	Q13541	EIF4EBP1	HPRD	PubMed
P23443	P28482	MAPK1	HPRD	PubMed
P23443	P27361	MAPK3	HPRD	PubMed
P23443	P45983	MAPK8	HPRD	PubMed
P23443	P45984	MAPK9	HPRD	PubMed
P23443	P10636	MAPT	HPRD	PubMed
P23443	P42345	MTOR	HPRD	PubMed
P23443	Q09161	NCBP1	HPRD	PubMed
P23443	Q9HC98	NEK6	HPRD	PubMed
P23443	Q15118	PDK1	HPRD	PubMed
P23443	O15530	PDPK1	HPRD	PubMed
P23443	P42336	PIK3CA	HPRD	PubMed
P23443	Q13526	PIN1	HPRD	PubMed
P23443	Q9BY77	POLDIP3	HPRD	PubMed
P23443	Q9ULJ8	PPP1R9A	HPRD	PubMed
P23443	Q96SB3	PPP1R9B	HPRD	PubMed
P23443	Protein phosphatase 2A, catalytic subunit, alpha isoform	PPP2CA	HPRD	PubMed
P23443	P63000	RAC1	HPRD	PubMed
P23443	P62753	RPS6	HPRD	PubMed
P23443	Raptor	RPTOR	HPRD	PubMed
P23443	Q15831	STK11	HPRD	PubMed
P23443	O14746	TERT	HPRD	PubMed
P23443	Q9BUZ4	TRAF4	HPRD	PubMed
P23443	O14980	XPO1	HPRD	PubMed
BioGRID:112112	BioGRID:106573	ACTA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112112	BioGRID:106710	AKT1	BioGRID	PubMed	Co-purification
BioGRID:112112	BioGRID:107160	BTK	BioGRID	PubMed	Biochemical Activity
BioGRID:112112	BioGRID:112978	CLEC3B	BioGRID	PubMed	Two-hybrid
BioGRID:112112	BioGRID:123254	COASY	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112112	BioGRID:107841	CSNK2A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112112	BioGRID:107843	CSNK2B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112112	BioGRID:120507	DPPA4	BioGRID	PubMed	Two-hybrid
BioGRID:112112	BioGRID:118953	EEF2K	BioGRID	PubMed	Reconstituted Complex
BioGRID:112112	BioGRID:114211	EIF3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:114212	EIF3C	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:114214	EIF3F	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112112	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112112	BioGRID:108935	GDI2P1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:112112	BioGRID:114375	KAT2B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112112	BioGRID:110245	LYN	BioGRID	PubMed	Biochemical Activity
BioGRID:112112	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:108757	MTOR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112112	BioGRID:110259	MXD1	BioGRID	PubMed	Biochemical Activity
BioGRID:112112	BioGRID:111189	PDK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112112	BioGRID:123998	POLDIP3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:112112	BioGRID:111512	PPP2R2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:111576	PRKCZ	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:115301	RBX1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112112	BioGRID:128962	RICTOR	BioGRID	PubMed	Reconstituted Complex
BioGRID:112112	BioGRID:121582	RPTOR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112112	BioGRID:112592	SRC	BioGRID	PubMed	Biochemical Activity
BioGRID:112112	BioGRID:112717	SYK	BioGRID	PubMed	Biochemical Activity
BioGRID:112112	BioGRID:112874	TERT	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:114979	TRAF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:113348	XPO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112112	BioGRID:222117	Xpo1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
peptide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
TOR signaling cascade	IDA Inferred from Direct Assay more info	PubMed
aging	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell migration	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
germ cell development	IEA Inferred from Electronic Annotation more info
insulin receptor signaling pathway	TAS Traceable Author Statement more info
long-term memory	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of skeletal muscle tissue growth	IEA Inferred from Electronic Annotation more info
positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
protein kinase B signaling cascade	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of glucose import	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to electrical stimulus involved in regulation of muscle adaptation	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
response to glucose stimulus	IEA Inferred from Electronic Annotation more info
response to heat	IEA Inferred from Electronic Annotation more info
response to insulin stimulus	IEA Inferred from Electronic Annotation more info
response to leucine	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
response to nutrient	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to testosterone stimulus	IEA Inferred from Electronic Annotation more info
response to toxin	IEA Inferred from Electronic Annotation more info
response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
response to wounding	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info
skeletal muscle atrophy	IEA Inferred from Electronic Annotation more info
skeletal muscle contraction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
cell surface	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
ribosome	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info
synapse	IEA Inferred from Electronic Annotation more info
synaptosome	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ribosomal protein S6 kinase beta-1

Names: ribosomal protein S6 kinase beta-1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1

NP_003152.1

EC 2.7.11.1

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029513.1 RefSeqGene

Range

5001..62345

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003161.2 → NP_003152.1 ribosomal protein S6 kinase beta-1

Status: REVIEWED

Source sequence(s)

AA424792, AC004686, AI806441, AK091503, BG614269, BP359158, BQ719717, CA444907, CB050838, M60724

Consensus CDS

CCDS11621.1

UniProtKB/Swiss-Prot

P23443

Related

ENSP00000225577, OTTHUMP00000198109, ENST00000225577, OTTHUMT00000319324

Conserved Domains (2) summary

cd05584
Location:94 – 416
Blast Score: 1806

STKc_p70S6K; Catalytic domain of the Protein Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

smart00220
Location:91 – 352
Blast Score: 832

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

57970443..58027787

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

53342977..53400248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004686.2 (4845..62189)	None
genomic	CH471109.2	EAW94382.1
		EAW94383.1
		EAW94384.1
genomic	CS498704.1	CAM82744.1
mRNA	AA424792.1	None
mRNA	AI806441.1	None
mRNA	AK026730.1	None
mRNA	AK091503.1	None
mRNA	AK293247.1	BAG56781.1
mRNA	AK297147.1	BAG59646.1
mRNA	AK300202.1	BAG61973.1
mRNA	AK312875.1	BAG35726.1
mRNA	BC030763.2	None
mRNA	BC036033.1	AAH36033.1
mRNA	BC053365.1	AAH53365.1
mRNA	BG614269.1	None
mRNA	BP359158.1	None
mRNA	BQ719717.1	None
mRNA	CA444907.1	None
mRNA	CB050838.1	None
mRNA	M60724.1	AAA36410.1
mRNA	M60725.1	AAA36411.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
P23443.2	GenPept	UniProtKB/Swiss-Prot:P23443
Q4G0X7	GenPept	UniProtKB/TrEMBL:Q4G0X7
Q7Z721	GenPept	UniProtKB/TrEMBL:Q7Z721