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RPL34 ribosomal protein L34 [ Homo sapiens (human) ]

Gene ID: 6164, updated on 8-May-2016
Official Symbol
RPL34provided by HGNC
Official Full Name
ribosomal protein L34provided by HGNC
Primary source
HGNC:HGNC:10340
See related
Ensembl:ENSG00000109475 HPRD:17996; MIM:616862; Vega:OTTHUMG00000131839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L34
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
Orthologs
Location:
4q25
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (108620566..108630484)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109541722..109551640)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene exocyst complex component 7 pseudogene 1 Neighboring gene RPL34 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC101929621 Neighboring gene uncharacterized LOC105377359 Neighboring gene oligosaccharyltransferase complex subunit (non-catalytic)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
    Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
  • Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
    Cytoplasmic Ribosomal Proteins, organism-specific biosystemThe contents of this pathway represents the ribosomal proteins involved in translation.
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Elongation, organism-specific biosystemThe translation elongation cycle adds one amino acid at a time to a growing polypeptide according to the sequence of codons found in the mRNA. The next available codon on the mRNA is exposed in the a...
  • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
  • Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Termination, organism-specific biosystemThe arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In euk...
  • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
    Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
  • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
    GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Influenza Infection, organism-specific biosystem (from REACTOME)
    Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
  • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
    Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
  • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
    Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
  • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
    L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
  • Major pathway of rRNA processing in the nucleolus, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
  • Peptide chain elongation, organism-specific biosystem (from REACTOME)
    Peptide chain elongation, organism-specific biosystemThe mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. ...
  • Ribosome, organism-specific biosystem (from KEGG)
    Ribosome, organism-specific biosystem
    Ribosome
  • Ribosome, conserved biosystem (from KEGG)
    Ribosome, conserved biosystem
    Ribosome
  • Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
  • Ribosome, eukaryotes, conserved biosystem (from KEGG)
    Ribosome, eukaryotes, conserved biosystemStructural complex; Genetic information processing; Ribosome
  • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
    SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
  • Selenoamino acid metabolism, organism-specific biosystem (from REACTOME)
    Selenoamino acid metabolism, organism-specific biosystemSelenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulp...
  • Selenocysteine synthesis, organism-specific biosystem (from REACTOME)
    Selenocysteine synthesis, organism-specific biosystemSelenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phos...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
  • Viral mRNA Translation, organism-specific biosystem (from REACTOME)
    Viral mRNA Translation, organism-specific biosystemSpliced and unspliced viral mRNA in the cytoplasm are translated by host cell ribosomal translation machinery (reviewed in Kash, 2006). At least ten viral proteins are synthesized: HA, NA, PB1, PB2...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111005

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
Preferred Names
60S ribosomal protein L34
Names
leukemia-associated protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000995.4NP_000986.2  60S ribosomal protein L34

    See identical proteins and their annotated locations for NP_000986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC106009, BM971961, CD249923
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional
  2. NM_001319232.1NP_001306161.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AA128015, AA128058, CD175155, DA779124
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional
  3. NM_001319234.1NP_001306163.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    CB132938, DA779124
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional
  4. NM_001319235.1NP_001306164.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BE394007, CD175155, DA779124
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional
  5. NM_001319236.1NP_001306165.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC106009, CD249923, DA779124
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional
  6. NM_033625.3NP_296374.1  60S ribosomal protein L34

    See identical proteins and their annotated locations for NP_296374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC001773, BM971961, CD175155
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Related
    ENSP00000378163, OTTHUMP00000219601, ENST00000394668, OTTHUMT00000363468
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    108620566..108630484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263172.2XP_005263229.1  

    Related
    ENSP00000378162, OTTHUMP00000162661, ENST00000394667, OTTHUMT00000254785
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional
  2. XM_006714287.1XP_006714350.1  

    Related
    ENSP00000378160, OTTHUMP00000162662, ENST00000394665, OTTHUMT00000254786
    Conserved Domains (1) summary
    PTZ00074
    Location:1117
    PTZ00074; 60S ribosomal protein L34; Provisional

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    109518568..109528486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)