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RPL15 ribosomal protein L15 [ Homo sapiens (human) ]

Gene ID: 6138, updated on 8-Feb-2015
Official Symbol
RPL15provided by HGNC
Official Full Name
ribosomal protein L15provided by HGNC
Primary source
HGNC:HGNC:10306
See related
Ensembl:ENSG00000174748; HPRD:16043; MIM:604174; Vega:OTTHUMG00000130485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L15; EC45; DBA12; RPL10; RPLY10; RPYL10
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]
Orthologs
See RPL15 in MapViewer
Location:
3p24.2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (23916804..23923696)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23958295..23965187)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene UBE2E2 antisense RNA 1 (head to head) Neighboring gene ubiquitin-conjugating enzyme E2E 2 Neighboring gene ADP-ribosylation factor-like 4A pseudogene Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene NFKB inhibitor interacting Ras-like 1 Neighboring gene nuclear receptor subfamily 1, group D, member 2 Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Diamond-Blackfan anemia 12
MedGen: CN182206 OMIM: 615550 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2014-07-16)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2014-07-16)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
  • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
    Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
  • Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
    Cytoplasmic Ribosomal Proteins, organism-specific biosystemThe contents of this pathway represents the ribosomal proteins involved in translation.
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Elongation, organism-specific biosystemThe translation elongation cycle adds one amino acid at a time to a growing polypeptide according to the sequence of codons found in the mRNA. The next available codon on the mRNA is exposed in the a...
  • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
  • Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Termination, organism-specific biosystemThe arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In euk...
  • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
    Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
  • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
    GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Influenza Infection, organism-specific biosystem (from REACTOME)
    Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
  • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
    Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
  • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
    Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
  • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
    L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
  • Peptide chain elongation, organism-specific biosystem (from REACTOME)
    Peptide chain elongation, organism-specific biosystemThe mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. ...
  • Ribosome, organism-specific biosystem (from KEGG)
    Ribosome, organism-specific biosystem
    Ribosome
  • Ribosome, conserved biosystem (from KEGG)
    Ribosome, conserved biosystem
    Ribosome
  • Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
  • Ribosome, eukaryotes, conserved biosystem (from KEGG)
    Ribosome, eukaryotes, conserved biosystemStructural complex; Genetic information processing; Ribosome
  • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
    SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
  • Viral mRNA Translation, organism-specific biosystem (from REACTOME)
    Viral mRNA Translation, organism-specific biosystemSpliced and unspliced viral mRNA in the cytoplasm are translated by host cell ribosomal translation machinery (reviewed in Kash, 2006). At least ten viral proteins are synthesized: HA, NA, PB1, PB2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26304, MGC88603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
 
translational elongation TAS
Traceable Author Statement
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
translational termination TAS
Traceable Author Statement
more info
 
viral life cycle TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribosome TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
60S ribosomal protein L15
Names
60S ribosomal protein L15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033850.1 RefSeqGene

    Range
    5001..11893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001253379.1NP_001240308.1  60S ribosomal protein L15 isoform 1

    See proteins identical to NP_001240308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC124914, DA037869
    Consensus CDS
    CCDS2640.1
    UniProtKB/TrEMBL
    A0A024R2Q4
    UniProtKB/Swiss-Prot
    P61313
    Related
    ENSP00000483260, ENST00000611050
    Conserved Domains (1) summary
    pfam00827
    Location:2193
    Ribosomal_L15e; Ribosomal L15
  2. NM_001253380.1NP_001240309.1  60S ribosomal protein L15 isoform 1

    See proteins identical to NP_001240309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AY347528, DB461802
    Consensus CDS
    CCDS2640.1
    UniProtKB/TrEMBL
    A0A024R2Q4
    UniProtKB/Swiss-Prot
    P61313
    Conserved Domains (1) summary
    pfam00827
    Location:2193
    Ribosomal_L15e; Ribosomal L15
  3. NM_001253382.1NP_001240311.1  60S ribosomal protein L15 isoform 1

    See proteins identical to NP_001240311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC124914, BE893727, BU178524
    Consensus CDS
    CCDS2640.1
    UniProtKB/TrEMBL
    A0A024R2Q4
    UniProtKB/Swiss-Prot
    P61313
    Conserved Domains (1) summary
    pfam00827
    Location:2193
    Ribosomal_L15e; Ribosomal L15
  4. NM_001253383.1NP_001240312.1  60S ribosomal protein L15 isoform 1

    See proteins identical to NP_001240312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC124914, DA205054, DC351786
    Consensus CDS
    CCDS2640.1
    UniProtKB/TrEMBL
    A0A024R2Q4
    UniProtKB/Swiss-Prot
    P61313
    Related
    ENSP00000416692, OTTHUMP00000208329, ENST00000413699, OTTHUMT00000340865
    Conserved Domains (1) summary
    pfam00827
    Location:2193
    Ribosomal_L15e; Ribosomal L15
  5. NM_001253384.1NP_001240313.1  60S ribosomal protein L15 isoform 2

    See proteins identical to NP_001240313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate exon in the 3' UTR and coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124914, BC081565
    Consensus CDS
    CCDS58818.1
    UniProtKB/Swiss-Prot
    P61313
    Related
    ENSP00000398788, ENST00000456530
    Conserved Domains (1) summary
    cl02977
    Location:2120
    Ribosomal_L15e; Ribosomal L15
  6. NM_002948.3NP_002939.2  60S ribosomal protein L15 isoform 1

    See proteins identical to NP_002939.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, 3, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AF283772
    Consensus CDS
    CCDS2640.1
    UniProtKB/TrEMBL
    A0A024R2Q4
    UniProtKB/Swiss-Prot
    P61313
    Related
    ENSP00000309334, OTTHUMP00000161052, ENST00000307839, OTTHUMT00000252885
    Conserved Domains (1) summary
    pfam00827
    Location:2193
    Ribosomal_L15e; Ribosomal L15

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38 Primary Assembly

    Range
    23916804..23923696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    23910110..23917002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 Alternate HuRef

    Range
    23904389..23911124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)