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ROS1 ROS proto-oncogene 1, receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6098, updated on 26-May-2016
Official Symbol
ROS1provided by HGNC
Official Full Name
ROS proto-oncogene 1, receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:10261
See related
Ensembl:ENSG00000047936 HPRD:01295; MIM:165020; Vega:OTTHUMG00000016188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROS; MCF3; c-ros-1
Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6q22
Exon count:
47
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (117287918..117425922, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (117609530..117747018, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377964 Neighboring gene vestigial like family member 2 Neighboring gene RAP1B, member of RAS oncogene family pseudogene 3 Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene uncharacterized LOC105377965

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
NHGRI GWA Catalog
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of ROS in umbilical cord blood mononuclear cells and T-cell lines PubMed
Tat tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
Vpr vpr Administration of recombinant Vpr to human neurons results in a slow but sustained elevation of intracellular calcium, which leads to ROS production and impairs glutamate signaling PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell growth IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
columnar/cuboidal epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphate transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proto-oncogene tyrosine-protein kinase ROS
Names
ROS proto-oncogene 1 , receptor tyrosine kinase
c-ros oncogene 1 , receptor tyrosine kinase
proto-oncogene c-Ros-1
transmembrane tyrosine-specific protein kinase
v-ros avian UR2 sarcoma virus oncogene homolog 1
NP_002935.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033929.1 RefSeqGene

    Range
    5001..142489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002944.2NP_002935.2  proto-oncogene tyrosine-protein kinase ROS precursor

    See identical proteins and their annotated locations for NP_002935.2

    Status: REVIEWED

    Source sequence(s)
    M34353
    Consensus CDS
    CCDS5116.1
    UniProtKB/Swiss-Prot
    P08922
    Related
    ENSP00000357494, OTTHUMP00000017814, ENST00000368508, OTTHUMT00000043464
    Conserved Domains (3) summary
    cd00063
    Location:202281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19452215
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19502216
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    117287918..117425922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536051.1XP_011534353.1  

    Conserved Domains (3) summary
    cd00063
    Location:202281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19462216
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19512217
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  2. XM_011536053.1XP_011534355.1  

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:18972167
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19022168
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  3. XM_006715548.2XP_006715611.1  

    Related
    ENSP00000357493, OTTHUMP00000017815, ENST00000368507, OTTHUMT00000043465
    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19402210
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19452211
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  4. XM_011536052.1XP_011534354.1  

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19412211
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19462212
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  5. XM_011536050.1XP_011534352.1  

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19542224
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19592225
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  6. XM_011536049.1XP_011534351.1  

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19552225
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19602226
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  7. XM_011536054.1XP_011534356.1  

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19552200
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:19602200
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011536055.1XP_011534357.1  

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  9. XM_011536056.1XP_011534358.1  

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  10. XM_011536057.1XP_011534359.1  

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  11. XM_011536058.1XP_011534360.1  

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    117873670..118011105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)