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    ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 [ Homo sapiens (human) ]

    Gene ID: 6059, updated on 5-May-2013
    Official Symbol
    ABCE1provided by HGNC
    Official Full Name
    ATP-binding cassette, sub-family E (OABP), member 1provided by HGNC
    Primary source
    HGNC:69
    Locus tag
    OK/SW-cl.40
    See related
    Ensembl:ENSG00000164163; HPRD:03132; MIM:601213; Vega:OTTHUMG00000161478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    4q31
    Sequence :
    Chromosome: 4; NC_000004.11 (146019156..146050676)
    See ABCE1 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505491 Neighboring gene heat shock 60kDa protein 1 (chaperonin) pseudogene 5 Neighboring gene anaphase promoting complex subunit 10 Neighboring gene OTU domain containing 4 Neighboring gene ribosomal protein S23 pseudogene 4

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Gag, Pr55 gag HIV-1 GagZip chimeric proteins, in which NC was replaced with a heterologous leucine zipper, form ABCE1-containing intermediates, suggesting exposure of an ABCE1-binding domain located elsewhere in Gag, outside NC PubMed
    gag ABCE1, DDX6, and AGO2 proteins are associated with HIV-1 Gag in the intracellular high-molecular-weight assembly intermediates PubMed
    gag The nucleocapsid (NC) domain of Gag is critical for interaction with endogenous ABCE1 in primate cells; basic residues in NC are critical for the Gag-ABCE1 interaction, while the cysteine and histidine residues in the zinc fingers are dispensable PubMed
    gag ABCE1 co-localizes with Gag clusters present at the plasma membrane PubMed
    gag Cells expressing a protease-deficient HIV-1 molecular clone demonstrate a prolonged association of Gag and ABCE1 PubMed
    gag Expression of TULA proteins reduces the production of HIV-1 particles and modulates Gag processing. ABCE1 recruits TULA to Gag PubMed
    gag Gag production is significantly increased by fusing HIV-1-infected CD4- and CXCR4-expressing rat fibroblasts with uninfected human T-, B-, and macrophage cell lines. This process is regulated by HP68 and MHC class II transactivator (CIITA) PubMed
    gag HP68 associates post-translationally with HIV-1 Gag and Vif, an interaction that requires the Nucleocapsid domain of Gag and that is essential for assembly of immature HIV-1 capsids PubMed
    Vif, p23 vif HuHP68 is essential for HIV-1 capsid assembly and associates with HIV-1 Vif in the form of an HuHP68 complex with HIV-1 Gag PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P61221 P10153 RNASE2    HPRD  PubMed  
    P61221 Q05823 RNASEL    HPRD  PubMed  
    BioGRID:111986 BioGRID:106671 AP1B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:121157 DIABLO    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:114214 EIF3F    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:114216 EIF3H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:122103 MMS19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:109180 PDIA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:111969 RNASEL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111986 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:119748 UBASH3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111986 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:131884 USP50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111986 BioGRID:1205537 gag    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    ribonuclease inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ATP-binding cassette sub-family E member 1
    Names
    ATP-binding cassette sub-family E member 1
    huHP68
    RNase L inhibitor
    ribonuclease 4 inhibitor
    2'-5'-oligoadenylate-binding protein
    ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040876.1NP_001035809.1  ATP-binding cassette sub-family E member 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC096757, BC016283, DA218189
      Consensus CDS
      CCDS34071.1
      UniProtKB/Swiss-Prot
      P61221
      Conserved Domains (4) summary
      COG1245
      Location:4597
      Blast Score: 2116
      COG1245; Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]
      pfam04068
      Location:637
      Blast Score: 128
      RLI; Possible Fer4-like domain in RNase L inhibitor, RLI
      cd03236
      Location:78332
      Blast Score: 1214
      ABC_RNaseL_inhibitor_domain1; The ATP-binding cassette domain 1 of RNase L inhibitor.
      cd03237
      Location:359592
      Blast Score: 1078
      ABC_RNaseL_inhibitor_domain2; The ATP-binding cassette domain 2 of RNase L inhibitor
    2. NM_002940.2NP_002931.2  ATP-binding cassette sub-family E member 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC096757, BC016283, DA218189
      Consensus CDS
      CCDS34071.1
      UniProtKB/Swiss-Prot
      P61221
      Related
      ENSP00000296577, OTTHUMP00000220305, ENST00000296577, OTTHUMT00000365104
      Conserved Domains (4) summary
      COG1245
      Location:4597
      Blast Score: 2116
      COG1245; Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]
      pfam04068
      Location:637
      Blast Score: 128
      RLI; Possible Fer4-like domain in RNase L inhibitor, RLI
      cd03236
      Location:78332
      Blast Score: 1214
      ABC_RNaseL_inhibitor_domain1; The ATP-binding cassette domain 1 of RNase L inhibitor.
      cd03237
      Location:359592
      Blast Score: 1078
      ABC_RNaseL_inhibitor_domain2; The ATP-binding cassette domain 2 of RNase L inhibitor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      146019156..146050676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      141750477..141781999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      145804790..145836309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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