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    Fignl1 fidgetin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 60530, updated on 26-Feb-2013
    Official Symbol
    Fignl1provided by MGI
    Official Full Name
    fidgetin-like 1provided by MGI
    Primary source
    MGI:1890648
    Locus tag
    RP23-373H2.1
    See related
    Ensembl:ENSMUSG00000035455; Vega:OTTMUSG00000005160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Location :
    11; 11 A2
    Sequence :
    Chromosome: 11; NC_000077.6 (11800288..11808962, complement)
    See Fignl1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930415F15 gene Neighboring gene IKAROS family zinc finger 1 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene dopa decarboxylase Neighboring gene growth factor receptor bound protein 10

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice. L'Hôte D, et al. PLoS One, 2011. PMID 22110678.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. mRNA expression analysis of cell cycle genes in islets of pregnant mice. Schraenen A, et al. Diabetologia, 2010 Dec. PMID 20886204.
    4. Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Shiura H, et al. Hum Mol Genet, 2009 Apr 15. PMID 19174477.
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Fignl1 as a novel actor in mammal's male meiosis dynamics
      Title: Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice.
    2. FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation.
      Title: Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    fidgetin-like protein 1
    Names
    fidgetin-like protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163359.1 → NP_001156831.1  fidgetin-like protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK143850, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q8BPY9
      Related
      ENSMUSP00000126340, ENSMUST00000171938
      Conserved Domains (3) summary
      cd00009
      Location:440 – 576
      Blast Score: 254
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:442 – 578
      Blast Score: 204
      AAA; ATPases associated with a variety of cellular activities
      pfam09336
      Location:647 – 680
      Blast Score: 94
      Vps4_C; Vps4 C terminal oligomerisation domain

    2. NM_001163360.1 → NP_001156832.1  fidgetin-like protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK143850, BY231020, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q8BPY9
      Related
      ENSMUSP00000127489, ENSMUST00000171080
      Conserved Domains (3) summary
      cd00009
      Location:440 – 576
      Blast Score: 254
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:442 – 578
      Blast Score: 204
      AAA; ATPases associated with a variety of cellular activities
      pfam09336
      Location:647 – 680
      Blast Score: 94
      Vps4_C; Vps4 C terminal oligomerisation domain

    3. NM_021891.3 → NP_068691.2  fidgetin-like protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK086769, AK143850, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q8BPY9
      Related
      ENSMUSP00000036932, OTTMUSP00000005361, ENSMUST00000047689, OTTMUST00000011528
      Conserved Domains (3) summary
      cd00009
      Location:440 – 576
      Blast Score: 254
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:442 – 578
      Blast Score: 204
      AAA; ATPases associated with a variety of cellular activities
      pfam09336
      Location:647 – 680
      Blast Score: 94
      Vps4_C; Vps4 C terminal oligomerisation domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p1 C57BL/6J

      Range
      11800288..11808962, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      12259567..12268241, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01090734.1 (7769..16443) None
    genomic AL596450.8 (26626..35300) None
    genomic CH466574.1 EDL40644.1 mixed
      EDL40645.1 mixed
      EDL40646.1 mixed
    mRNA AF263914.1 AAG17290.1 C57BL/6J
    mRNA AK051324.1 None C57BL/6J
    mRNA AK051874.1 BAC34796.1 C57BL/6J
    mRNA AK082092.1 None C57BL/6J
    mRNA AK086769.1 None C57BL/6J
    mRNA AK088574.1 BAC40431.1 NOD
    mRNA AK143850.1 BAE25569.1 C57BL/6J
    mRNA AK148994.1 BAE28713.1 C57BL/6J
    mRNA BC051942.1 AAH51942.1 C57BL/6
    mRNA BC052415.1 AAH52415.1 C57BL/6
    mRNA BY231020.1 None C57BL/6J
    mRNA CN693395.1 None C57BL/6J
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPY9.1 GenPept UniProtKB/Swiss-Prot:Q8BPY9

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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