Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    Acss2 acyl-CoA synthetase short-chain family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 60525, updated on 18-May-2013
    Official Symbol
    Acss2provided by MGI
    Official Full Name
    acyl-CoA synthetase short-chain family member 2provided by MGI
    Primary source
    MGI:1890410
    Locus tag
    RP23-260N23.4
    See related
    Ensembl:ENSMUSG00000027605; Vega:OTTMUSG00000016058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACAS; Acs1; Acas1; Acas2; AceCS1; 1110017C11Rik
    Location :
    2; 2 H2
    Sequence :
    Chromosome: 2; NC_000068.7 (155518043..155562743)
    See Acss2 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic-like Neighboring gene gamma-glutamyltransferase 7 Neighboring gene RIKEN cDNA 4930471I20 gene Neighboring gene glutathione synthetase Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. Ariyannur PS, et al. J Comp Neurol, 2010 Aug 1. PMID 20533355.
    4. Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Yoshii Y, et al. Cancer Sci, 2009 May. PMID 19445015.
    5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells.
      Title: Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.
    2. ACSS2 might play a buffering role in tumor acetyl-CoA/acetate metabolism
      Title: Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism.
    3. Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated
      Title: Expression of cytosolic acetyl-CoA synthetase gene is developmentally regulated.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acetate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acetate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acetyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    propionate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    acetyl-coenzyme A synthetase, cytoplasmic
    Names
    acetyl-coenzyme A synthetase, cytoplasmic
    ACS
    aceCS
    acetate--CoA ligase
    acyl-activating enzyme
    acetyl-CoA synthetase 1
    acetyl-Coenzyme A synthetase 1 (AMP forming)
    acetyl-Coenzyme A synthetase 2 (ADP forming)
    acetyl-Coenzyme A synthetase 2 (AMP forming)
    NP_062785.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019811.3 → NP_062785.2  acetyl-coenzyme A synthetase, cytoplasmic

      Status: PROVISIONAL

      Source sequence(s)
      AL844852
      Consensus CDS
      CCDS16950.1
      UniProtKB/Swiss-Prot
      Q9QXG4
      Related
      ENSMUSP00000029135, OTTMUSP00000017177, ENSMUST00000029135, OTTMUST00000038330
      Conserved Domains (4) summary
      PRK00174
      Location:31 – 692
      Blast Score: 2709
      PRK00174; acetyl-CoA synthetase; Provisional
      pfam00501
      Location:137 – 577
      Blast Score: 851
      AMP-binding; AMP-binding enzyme
      pfam11930
      Location:43 – 129
      Blast Score: 228
      DUF3448; Domain of unknown function (DUF3448)
      pfam13193
      Location:642 – 685
      Blast Score: 168
      DUF4009; Domain of unknown function (DUF4009)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p1 C57BL/6J

      Range
      155518043..155562743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      161450232..161494992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01022366.1 None
    genomic AAHY01022367.1 None
    genomic AAHY01022368.1 None
    genomic AB060299.1 None
    genomic AL844852.11 (82594..127295) None
    genomic CH466551.1 EDL06127.1 mixed
    mRNA AF216873.1 AAF24510.1
    mRNA AK003738.1 None C57BL/6J
    mRNA AK028586.1 BAC26019.1 C57BL/6J
    mRNA AK029014.1 BAC26243.1 C57BL/6J
    mRNA AK029262.1 BAC26360.1 C57BL/6J
    mRNA AK041520.1 BAC30971.1 C57BL/6J
    mRNA AK053877.1 BAC35571.1 C57BL/6J
    mRNA AK085932.1 None C57BL/6J
    mRNA AK086921.1 None C57BL/6J
    mRNA AK093831.1 BAC04235.1
    mRNA BC040790.1 None FVB/N
    mRNA BC051432.1 AAH51432.1 FVB/N-3
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXG4.2 GenPept UniProtKB/Swiss-Prot:Q9QXG4

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...