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MRPS35 mitochondrial ribosomal protein S35 [ Homo sapiens (human) ]

Gene ID: 60488, updated on 8-May-2016
Official Symbol
MRPS35provided by HGNC
Official Full Name
mitochondrial ribosomal protein S35provided by HGNC
Primary source
HGNC:HGNC:16635
See related
Ensembl:ENSG00000061794 HPRD:11373; MIM:611995; Vega:OTTHUMG00000169215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS023; MRPS28; MRP-S28; HDCMD11P
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Orthologs
Location:
12p11
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (27710773..27756304)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27863706..27909237)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RAB15 effector protein Neighboring gene high mobility group box 1 pseudogene 49 Neighboring gene MANSC domain containing 4 Neighboring gene kelch like family member 42

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104278, DKFZp762P093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
Preferred Names
28S ribosomal protein S35, mitochondrial
Names
28S ribosomal protein S28, mitochondrial
MRP-S35
MRPS35
S28mt
S35mt
mitochondrial ribosomal protein S28

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190864.1NP_001177793.1  28S ribosomal protein S35, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177793.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI538796, AK075378, BC015862, DA747094
    Consensus CDS
    CCDS53769.1
    UniProtKB/Swiss-Prot
    P82673
    Related
    ENSP00000445390, OTTHUMP00000240422, ENST00000538315, OTTHUMT00000402899
  2. NM_021821.3NP_068593.2  28S ribosomal protein S35, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_068593.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI538796, BC015862, DA747094
    Consensus CDS
    CCDS8714.1
    UniProtKB/Swiss-Prot
    P82673
    Related
    ENSP00000081029, OTTHUMP00000240420, ENST00000081029, OTTHUMT00000402897
    Conserved Domains (1) summary
    pfam10213
    Location:148251
    MRP-S28; Mitochondrial ribosomal subunit protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    27710773..27756304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    27828692..27874201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)