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TRMT11 tRNA methyltransferase 11 homolog [ Homo sapiens (human) ]

Gene ID: 60487, updated on 26-May-2016
Official Symbol
TRMT11provided by HGNC
Official Full Name
tRNA methyltransferase 11 homologprovided by HGNC
Primary source
HGNC:HGNC:21080
See related
Ensembl:ENSG00000066651 HPRD:12898; Vega:OTTHUMG00000015515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM11; MDS024; C6orf75; TRMT11-1
Orthologs
Location:
6q11.1-q22.33
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (125986430..126039276)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126307576..126360422)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 7 Neighboring gene uncharacterized LOC105377987 Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene uncharacterized LOC101928096 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 5

NHGRI GWAS Catalog

Description
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tRNA (guanine-N2-)-methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
tRNA methylation IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tRNA (guanine(10)-N2)-methyltransferase homolog
Names
tRNA guanosine-2'-O-methyltransferase TRM11 homolog
NP_001026882.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031712.2NP_001026882.2  tRNA (guanine(10)-N2)-methyltransferase homolog

    See identical proteins and their annotated locations for NP_001026882.2

    Status: VALIDATED

    Source sequence(s)
    AF532977, BC056878
    Consensus CDS
    CCDS35496.1
    UniProtKB/Swiss-Prot
    Q7Z4G4
    Related
    ENSP00000333934, ENST00000334379
    Conserved Domains (2) summary
    cd02440
    Location:219377
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG1041
    Location:9416
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    125986430..126039276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715546.2XP_006715609.1  

    Related
    ENSP00000433724, OTTHUMP00000017152, ENST00000479748, OTTHUMT00000042095
    Conserved Domains (2) summary
    COG1041
    Location:9246
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:190246
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011536044.1XP_011534346.1  

    Related
    ENSP00000467035, OTTHUMP00000265349, ENST00000468097, OTTHUMT00000042098
    Conserved Domains (1) summary
    COG1041
    Location:9230
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_942548.1 RNA Sequence

  2. XR_942550.1 RNA Sequence

  3. XR_942549.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    126571484..126624331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021820.1: Suppressed sequence

    Description
    NM_021820.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate; both the transcript and the protein have no support.