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    RNF5 ring finger protein 5, E3 ubiquitin protein ligase [ Homo sapiens ]

    Gene ID: 6048, updated on 11-May-2012
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    Summary

    Official Symbol
    RNF5provided by HGNC
    Official Full Name
    ring finger protein 5, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:10068
    Locus tag
    DAAP-218M18.2
    See related
    Ensembl:ENSG00000204308; HPRD:04057; MIM:602677; Vega:OTTHUMG00000031093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RMA1; RING5
    Summary
    The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (32146162..32148570)
    See RNF5 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507547 Neighboring gene PPT2-EGFL8 readthrough Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene pre-B-cell leukemia homeobox 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508. Grove DE, et al. Mol Biol Cell, 2011 Feb 1. PMID 21148293.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. Zhong B, et al. J Immunol, 2010 Jun 1. PMID 20483786.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRDeltaF508 for degradation.
      Title: The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    3. RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP.
      Title: Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).
    4. E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner
      Title: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.
    6. RNF5 is a novel regulator of breast cancer progression through its effect on actin cytoskeletal alterations.
      Title: Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer.
    7. efficient bacterial escape into the cytosol of epithelial cells requires HsRMA1-mediated SopA ubiquitination and contributes to Salmonella-induced enteropathogenicity
      Title: Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1.
    8. the G(16)-mediated activation of IKK/NFkappaB by N(6)-cyclohexyladenosine requires a complex signaling network composed of multiple intermediates
      Title: G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling.
    9. RNF5 regulates cell motility by targeting paxillin ubiquitination and altered localization
      Title: RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.
    10. found in cerebral microvessels endothelium
      Title: NG2 immunoreactivity on human brain endothelial cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q99942 O95870 ABHD16A    HPRD  PubMed  
    Q99942 P13569 CFTR    HPRD  PubMed  
    Q99942 Q9Y613 FHOD1    HPRD  PubMed  
    Q99942 O75970 MPDZ    HPRD  PubMed  
    Q99942 P49023 PXN    HPRD  PubMed  
    Q99942 P36897 TGFBR1    HPRD  PubMed  
    Q99942 P62837 UBE2D2    HPRD  PubMed  
    Q99942 P61077 UBE2D3    HPRD  PubMed  
    Q99942 P51965 UBE2E1    HPRD  PubMed  
    Q99942 Q969T4 UBE2E3    HPRD  PubMed  
    BioGRID:111975 BioGRID:113650 ABHD16A    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:106764 AMFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111975 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111975 BioGRID:118877 FHOD1    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:119590 JKAMP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111975 BioGRID:121570 MAVS    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111975 BioGRID:111975 RNF5    BioGRID  PubMed Biochemical Activity 
    BioGRID:111975 BioGRID:130988 TMEM173    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111975 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111975 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:113172 UBE2E1    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:113173 UBE2E2    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:115740 UBE2E3    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:109340 UBE2K    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:113183 UBE2V1    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:111975 BioGRID:122419 UBE2Z    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ER-associated misfolded protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF5
    Names
    E3 ubiquitin-protein ligase RNF5
    protein G16
    ram1 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006913.3 → NP_008844.1  E3 ubiquitin-protein ligase RNF5

      Status: REVIEWED

      Source sequence(s)
      BC004155, BC127652, BM712189
      Consensus CDS
      CCDS4745.1
      UniProtKB/Swiss-Prot
      Q99942
      Related
      ENSP00000364235, OTTHUMP00000029107, ENST00000375094, OTTHUMT00000076133
      Conserved Domains (2) summary
      cd00162
      Location:26 – 71
      Blast Score: 110
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      PLN03208
      Location:25 – 116
      Blast Score: 220
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      32146162..32148570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p5 ALT_REF_LOCI_1

      Range
      3460903..3463311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      3616843..3619251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      3488986..3491394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      3525991..3528397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      3407182..3409590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      3493890..3496298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31900360..31902768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL662830.14 (2024..4432) None
    genomic AL662884.11 (91210..93618) None
    genomic AL845464.5 CAI41808.1
    genomic BX284686.9 CAM26222.1
    genomic BX927239.5 CAQ06594.1
    genomic CH471081.1 EAX03607.1
      EAX03608.1
      EAX03609.1
    genomic CQ834264.1 CAH05347.1
    genomic CR812478.6 CAQ10698.1
    genomic CR933878.7 CAQ09623.1
    genomic U89336.1 AAB47492.1
    mRNA AB056869.1 BAB39359.1
    mRNA AJ243936.1 CAB51286.1
    mRNA AK296212.1 BAG58938.1
    mRNA AK311859.1 BAG34800.1
    mRNA AL555609.3 None
    mRNA BC004155.2 AAH04155.1
    mRNA BC020290.1 None
    mRNA BC111392.1 AAI11393.1
    mRNA BC119741.1 AAI19742.1
    mRNA BC119742.1 AAI19743.1
    mRNA BC127651.1 AAI27652.1
    mRNA BC127652.1 AAI27653.1
    mRNA BC148255.1 AAI48256.1
    mRNA BM712189.1 None
    mRNA BT007105.1 AAP35769.1
    mRNA BU599297.1 None
    other-genetic JF432457.1 ADZ15674.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99942.1 GenPept UniProtKB/Swiss-Prot:Q99942
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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