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    BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ]

    Gene ID: 604, updated on 4-Feb-2012

    Summary

    Official Symbol
    BCL6provided by HGNC
    Official Full Name
    B-cell CLL/lymphoma 6provided by HGNC
    Primary source
    HGNC:1001
    See related
    Ensembl:ENSG00000113916; HPRD:00180; MIM:109565; Vega:OTTHUMG00000156441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
    Summary
    The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

    Genomic context

    Location :
    3q27
    Sequence :
    Chromosome: 3; NC_000003.11 (187439165..187463513, complement)
    See BCL6 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene hCG1645011-like Neighboring gene somatostatin Neighboring gene receptor (chemosensory) transporter protein 2 Neighboring gene uncharacterized LOC100505844 Neighboring gene LPP antisense RNA 2 (non-protein coding) Neighboring gene LIM domain containing preferred translocation partner in lipoma

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of BCL-6 in Kaposi's sarcoma cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001697.2 NC_000017.9 CCL3    BIND  PubMed BCL6 interacts with the CCL3 promoter region. 
    NP_001697.2 NC_000012.9 CCND2    BIND  PubMed BCL6 interacts with the CCND2 promoter region. 
    NP_001697.2 NP_006303.1 NCOR2    BIND  PubMed The lateral groove motif in the BTB domain of BCL6 interacts with the BBD motif of SMRT. 
    NP_001697.2 NP_006229.1 PPARD    BIND  PubMed PPAR-delta interacts with BCL-6. This interaction was modelled on a demonstrated interaction between mouse PPAR-delta and human BCL-6. 
    NP_001697.2 NC_000017.9 TP53    BIND  PubMed BCL6 interacts with the p53 promoter region. 
    P41182 P41182 BCL6    HPRD  PubMed  
    P41182 Q8N143 BCL6B    HPRD  PubMed  
    P41182 Q6W2J9 BCOR    HPRD  PubMed  
    P41182 Q09472 EP300    HPRD  PubMed  
    P41182 P56524 HDAC4    HPRD  PubMed  
    P41182 Q9UQL6 HDAC5    HPRD  PubMed  
    P41182 Q8WUI4 HDAC7    HPRD  PubMed  
    P41182 Q9UKV0 HDAC9    HPRD  PubMed  
    P41182 Q15306 IRF4    HPRD  PubMed  
    P41182 P05412 JUN    HPRD  PubMed  
    P41182 P17275 JUNB    HPRD  PubMed  
    P41182 P17535 JUND    HPRD  PubMed  
    P41182 P28482 MAPK1    HPRD  PubMed  
    P41182 O75376 NCOR1    HPRD  PubMed  
    P41182 Q9Y618 NCOR2    HPRD  PubMed  
    P41182 Q03181 PPARD    HPRD  PubMed  
    P41182 O94806 PRKD3    HPRD  PubMed  
    P41182 Q06455 RUNX1T1    HPRD  PubMed  
    P41182 Q96ST3 SIN3A    HPRD  PubMed  
    P41182 P08047 SP1    HPRD  PubMed  
    P41182 Q96J92 WNK4    HPRD  PubMed  
    P41182 Q05516 ZBTB16    HPRD  PubMed  
    P41182 O95365 ZBTB7A    HPRD  PubMed  
    BioGRID:107076 BioGRID:109166 ARHGAP35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:115244 ARNT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:116206 ATF7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:121913 BACH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107076 BioGRID:119737 BCL11A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:129125 BCL6B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:120228 BCOR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:107227 CACNA1A    BioGRID  PubMed Affinity Capture-MS 
    Q12873 CHD3    BIND  PubMed BCL6 interacts with Mi2. 
    BioGRID:107076 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:107777 CREBBP    BioGRID  PubMed Biochemical Activity 
    BioGRID:107076 BioGRID:122185 CSMD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:108022 DDX6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:108109 DNAH9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:118870 DROSHA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:108203 E2F3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:108211 EBF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:122908 EHMT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:114840 EIF2AK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:121148 EIF4ENIF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107076 BioGRID:108365 EPHB6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:108385 ERCC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:123173 FBXO11    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107076 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107076 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:115083 HDAC9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:112789 HNF1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:109532 HSF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:124870 IDI2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:109870 IRF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:109928 JUN    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:109929 JUNB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107076 BioGRID:109930 JUND    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107076 BioGRID:116639 KDM2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:116895 KIF13B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:114611 LPAR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:109105 LPAR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:118104 LSM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:116774 MAPK8IP3    BioGRID  PubMed Affinity Capture-MS 
    NP_003917.1 MBD3    BIND  PubMed BCL6 interacts with MBD3. 
    BioGRID:107076 BioGRID:119788 MBD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107076 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:115104 MLL4    BioGRID  PubMed Affinity Capture-MS 
    NP_065795.1 MTA3    BIND  PubMed BCL6 interacts with MTA3. 
    BioGRID:107076 BioGRID:121568 MTA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:121002 NKRF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:118917 OLA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:125379 OSBPL1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:125498 PANX3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:122274 PARP12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:111134 PCDH9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:128336 PIKFYVE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:111384 PML    BioGRID  PubMed Two-hybrid 
    BioGRID:107076 BioGRID:117361 POU2F3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:114171 PPAP2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:116097 PPARGC1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:124528 PRIC285    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:117199 PRKD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:115366 SAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:121491 SENP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:112492 SMO    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:112566 SPI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107076 BioGRID:114894 SPTLC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:203414 Sp1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107076 BioGRID:107381 TNFRSF8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:123249 TRAF3IP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:121756 TRIB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:120923 UTP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:121598 WDR35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:122421 WNK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:119514 WNT16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:113498 ZBTB16    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107076 BioGRID:119488 ZBTB7A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107076 BioGRID:117146 ZMYND8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107076 BioGRID:115518 ZNF443    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell apoptosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of S phase of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of T-helper 2 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of isotype switching to IgE isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mast cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular component movement IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into nucleus, translocation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of germinal center formation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of memory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    B-cell lymphoma 6 protein
    Names
    B-cell lymphoma 6 protein
    BCL-5
    BCL-6
    protein LAZ-3
    zinc finger protein 51
    B-cell lymphoma 5 protein
    B-cell lymphoma 6 protein transcript
    zinc finger transcription factor BCL6S
    cys-his2 zinc finger transcription factor
    zinc finger and BTB domain-containing protein 27
    lymphoma-associated zinc finger gene on chromosome 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007149.1 RefSeqGene

      Range
      4811..29159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130845.1NP_001124317.1  B-cell lymphoma 6 protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a downstream and alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AW470156, BC146796, BC150184, CN401512
      Consensus CDS
      CCDS3289.1
      UniProtKB/Swiss-Prot
      P41182
      Related
      ENSP00000232014, OTTHUMP00000209897, ENST00000232014, OTTHUMT00000344205
      Conserved Domains (2) summary
      pfam13465
      Location:588613
      Blast Score: 101
      zf-H2C2_2; Zinc-finger double domain
      cl02518
      Location:22126
      Blast Score: 284
      BTB; BTB/POZ domain
    2. NM_001134738.1NP_001128210.1  B-cell lymphoma 6 protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, as compared to isoform 2.
      Source sequence(s)
      AW337942, BC146796, BC150184, EU883531, Z21943
      Consensus CDS
      CCDS46975.1
      UniProtKB/TrEMBL
      B5B0A5
      UniProtKB/TrEMBL
      B8PSA7
      UniProtKB/Swiss-Prot
      P41182
      Related
      ENSP00000413122, OTTHUMP00000209900, ENST00000450123, OTTHUMT00000344211
      Conserved Domains (3) summary
      pfam13465
      Location:532557
      Blast Score: 104
      zf-H2C2_2; Zinc-finger double domain
      cl02518
      Location:22126
      Blast Score: 285
      BTB; BTB/POZ domain
      cl15478
      Location:519540
      Blast Score: 77
      zf-C2H2; Zinc finger, C2H2 type
    3. NM_001706.4NP_001697.2  B-cell lymphoma 6 protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
      Source sequence(s)
      AI624861, BC146796, BC150184, DB079847
      Consensus CDS
      CCDS3289.1
      UniProtKB/Swiss-Prot
      P41182
      Related
      ENSP00000384371, OTTHUMP00000209895, ENST00000406870, OTTHUMT00000344202
      Conserved Domains (2) summary
      pfam13465
      Location:588613
      Blast Score: 101
      zf-H2C2_2; Zinc-finger double domain
      cl02518
      Location:22126
      Blast Score: 284
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      187439165..187463513, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      184843368..184867718, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

     

    1. NM_138931.1: Suppressed sequence

      Description
      NM_138931.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC072022.19 (37338..61648) None
    genomic AF240680.1 None
    genomic CH471052.2 EAW78140.1
      EAW78141.1
    genomic M88362.1 AAA61320.1
    genomic Z79581.1 None
    mRNA AI624861.1 None
    mRNA AK304325.1 BAG65174.1
    mRNA AK308162.1 None
    mRNA AW337942.1 None
    mRNA AW470156.1 None
    mRNA BC142705.1 AAI42706.1
    mRNA BC146796.1 None
    mRNA BC150184.1 AAI50185.1
    mRNA BX649185.1 CAE46203.1
    mRNA CN401512.1 None
    mRNA DB025893.1 None
    mRNA DB079847.1 None
    mRNA EU139066.1 ABX45135.1
    mRNA EU883531.1 ACG60659.1
    mRNA S67779.1 None
    mRNA U00115.1 AAC50054.1
    mRNA Z21943.1 CAA79937.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P41182.1 GenPept UniProtKB/Swiss-Prot:P41182
    Q15924 GenPept UniProtKB/TrEMBL:Q15924

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