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TSKS testis specific serine kinase substrate [ Homo sapiens (human) ]

Gene ID: 60385, updated on 8-May-2016
Official Symbol
TSKSprovided by HGNC
Official Full Name
testis specific serine kinase substrateprovided by HGNC
Primary source
HGNC:HGNC:30719
See related
Ensembl:ENSG00000126467 HPRD:09748; MIM:608253; Vega:OTTHUMG00000183249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSKS1; TSSKS; STK22S1; PPP1R161
Summary
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (49739753..49763328, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50243011..50266587, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adrenomedullin 5 (putative) Neighboring gene carnitine palmitoyltransferase 1C Neighboring gene ribosomal protein S9 pseudogene 4 Neighboring gene uncharacterized LOC105372434 Neighboring gene adaptor related protein complex 2 alpha 1 subunit Neighboring gene microRNA 6799 Neighboring gene uncharacterized LOC105372435 Neighboring gene fuzzy planar cell polarity protein

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
testis-specific serine kinase substrate
Names
STK22 substrate 1
protein phosphatase 1, regulatory subunit 161
testis specific serine/threonine kinase substrate
testis-specific kinase substrate

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021733.1NP_068379.1  testis-specific serine kinase substrate

    See identical proteins and their annotated locations for NP_068379.1

    Status: REVIEWED

    Source sequence(s)
    AF200923
    Consensus CDS
    CCDS12780.1
    UniProtKB/Swiss-Prot
    Q9UJT2
    Related
    ENSP00000246801, OTTHUMP00000271246, ENST00000246801, OTTHUMT00000465795
    Conserved Domains (1) summary
    pfam15358
    Location:26592
    TSKS; Testis-specific serine kinase substrate

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    49739753..49763328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527201.1XP_011525503.1  

    Conserved Domains (1) summary
    pfam15358
    Location:26617
    TSKS; Testis-specific serine kinase substrate
  2. XM_005259130.2XP_005259187.1  

    Conserved Domains (1) summary
    pfam15358
    Location:26499
    TSKS; Testis-specific serine kinase substrate
  3. XM_011527202.1XP_011525504.1  

    Conserved Domains (1) summary
    pfam15358
    Location:26499
    TSKS; Testis-specific serine kinase substrate
  4. XM_011527203.1XP_011525505.1  

    Conserved Domains (1) summary
    pfam15358
    Location:26541
    TSKS; Testis-specific serine kinase substrate

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    50244803..50268301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)