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RNASE3 ribonuclease A family member 3 [ Homo sapiens (human) ]

Gene ID: 6037, updated on 12-May-2016
Official Symbol
RNASE3provided by HGNC
Official Full Name
ribonuclease A family member 3provided by HGNC
Primary source
HGNC:HGNC:10046
See related
Ensembl:ENSG00000169397 HPRD:00575; MIM:131398; Vega:OTTHUMG00000029604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECP; RAF1; RNS3
Summary
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
Orthologs
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (20891403..20892348)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21359562..21360507)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370397 Neighboring gene ribonuclease A family member k6 Neighboring gene ribonuclease A family member 1, pancreatic Neighboring gene uncharacterized LOC100507513 Neighboring gene ribonuclease A family member 2 pseudogene Neighboring gene ribonuclease A family member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Asthma, organism-specific biosystem (from KEGG)
    Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
  • Asthma, conserved biosystem (from KEGG)
    Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA catabolic process TAS
Traceable Author Statement
more info
PubMed 
RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response in mucosa IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eosinophil cationic protein
Names
RNase 3
cytotoxic ribonuclease
ribonuclease 3
ribonuclease, RNase A family, 3
NP_002926.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002935.2NP_002926.2  eosinophil cationic protein precursor

    See identical proteins and their annotated locations for NP_002926.2

    Status: REVIEWED

    Source sequence(s)
    BX280390, M28128, X15161
    Consensus CDS
    CCDS9560.1
    UniProtKB/Swiss-Prot
    P12724
    Related
    ENSP00000302324, OTTHUMP00000164017, ENST00000304639, OTTHUMT00000073795
    Conserved Domains (1) summary
    cd06265
    Location:33157
    RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have been ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    20891403..20892348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    21361699..21362644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)