BCL3 B-cell CLL/lymphoma 3 [Homo sapiens] - Gene

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Summary

Official Symbol: BCL3provided by HGNC
Official Full Name: B-cell CLL/lymphoma 3provided by HGNC
Primary source: HGNC:998
See related: Ensembl:ENSG00000069399; HPRD:00179; MIM:109560; Vega:OTTHUMG00000151517
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BCL4; D19S37
Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19q13.1-q13.2

Sequence :: Chromosome: 19; NC_000019.9 (45251978..45263301)

See BCL3 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel mechanism for regulatory control of CTCF in UV stress-induced human corneal epithelial cells, which requires activation and formation of Bcl-3/p50 complex through a noncanonical NF-kappaB pathway
Title: Activation of oxidative stress-regulated Bcl-3 suppresses CTCF in corneal epithelial cells.
inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene, BCL3
Title: MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.
COX-2 inhibitor can inhibit the expression of BCL-3 and cyclin D1 in a dose-dependent manner human colon cancer cell line SW480.
Title: [Effect of COX-2 inhibitor on the expression of BCL-3 and cyclin D1 in human colon cancer cell line SW480].
We validated STAT3 as a bona fide target of BCL3 in a cervical cancer cell line by additional interference RNA and in silico analyses of previously reported lymphoma patients.
Title: Gene regulation by BCL3 in a cervical cancer cell line.
found that depleting Bcl-3 protein using shRNAs induce a decrease of proliferation and clonogenic survival associated with the induction of multinucleation and increased ploidy
Title: Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Genetic variations of UBE2L3 and BCL3 are potential new risk genes for Crohn's disease.
Title: Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
this study reveals a novel combinatorial role for Bcl3 and CtBP1, providing an explanation for the acquisition of resistance to apoptosis in cancer cells, which is a major requirement for cancer development.
Title: Bcl3-dependent stabilization of CtBP1 is crucial for the inhibition of apoptosis and tumor progression in breast cancer.
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
Data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein.
Title: BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.

Submit: New GeneRIF Correction See all (39)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
NP_005169.1	NC_000011.8	CD82	BIND	PubMed	BCL3 interacts with the CD82 (KAI1) promoter.
NP_005169.1	NP_001895.1	CTNNB1	BIND	PubMed	CTNNB1 (beta-catenin) interacts with BCL3.
NP_005169.1	NP_063937.2	GSK3A	BIND	PubMed	GSK3-alpha interacts with BCL-3.
NP_005169.1	NP_002084.2	GSK3B	BIND	PubMed	GSK3-beta interacts with and phosphorylates BCL-3.
NP_005169.1	NP_004955.2	HDAC1	BIND	PubMed	HDAC1 interacts with BCL-3.
NP_005169.1	NP_003874.2	HDAC3	BIND	PubMed	HDAC3 interacts with BCL-3.
NP_005169.1	NP_006035.2	HDAC6	BIND	PubMed	HDAC6 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between HDAC6 from an unspecified species and human BCL-3.
NP_005169.1		KAT5	BIND	PubMed	HTATIP (Tip60) interacts with BCL3.
NP_005169.1	NP_002737.1	MAPK3	BIND	PubMed	Erk1 interacts with and phosphorylates BCL-3.
NP_005169.1	NP_003989.2	NFKB1	BIND	PubMed	p50 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between p50 from an unspecified species and human BCL-3.
NP_005169.1	NP_003989.2	NFKB1	BIND	PubMed	NFKB1 (p50) interacts with BCL3.
NP_005169.1	NP_002493.2	NFKB2	BIND	PubMed	p52 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between p52 from an unspecified species and human BCL-3.
NP_005169.1	NP_006657.1	RUVBL2	BIND	PubMed	RUVBL2 (reptin) interacts with BCL3.
P20749	Q99728	BARD1	HPRD	PubMed
P20749	Q92905	COPS5	HPRD	PubMed
P20749	Q92793	CREBBP	HPRD	PubMed
P20749	P35222	CTNNB1	HPRD	PubMed
P20749	P01100	FOS	HPRD	PubMed
P20749	P06241	FYN	HPRD	PubMed
P20749	P49840	GSK3A	HPRD	PubMed
P20749	P49841	GSK3B	HPRD	PubMed
P20749	P52655	GTF2A1	HPRD	PubMed
P20749	Q00403	GTF2B	HPRD	PubMed
P20749	Q13547	HDAC1	HPRD	PubMed
P20749	O15379	HDAC3	HPRD	PubMed
P20749	Q9UBN7	HDAC6	HPRD	PubMed
P20749	P05412	JUN	HPRD	PubMed
P20749	Q92993	KAT5	HPRD	PubMed
P20749	P27361	MAPK3	HPRD	PubMed
P20749	Nedd4 binding protein 2	N4BP2	HPRD	PubMed
P20749	Q15788	NCOA1	HPRD	PubMed
P20749	P19838	NFKB1	HPRD	PubMed
P20749	Q00653	NFKB2	HPRD	PubMed
P20749	P51151	RAB9A	HPRD	PubMed
P20749	Q9Y230	RUVBL2	HPRD	PubMed
P20749	P19793	RXRA	HPRD	PubMed
P20749	P29353	SHC1	HPRD	PubMed
P20749	P20226	TBP	HPRD	PubMed
BioGRID:107074	BioGRID:114908	BAG2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107074	BioGRID:107056	BARD1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:107869	CTBP1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107074	BioGRID:107870	CTBP2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107074	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:107920	CYLD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:108347	EP300	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:117645	FBXW8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:108636	FOS	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:108810	FYN	BioGRID	PubMed	Reconstituted Complex
BioGRID:107074	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107074	BioGRID:109212	GTF2A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107074	BioGRID:109214	GTF2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:107074	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:115330	HDAC6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107074	BioGRID:109928	JUN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:116667	KDM1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:120848	N4BP2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:114200	NCOA1	BioGRID	PubMed	Two-hybrid
BioGRID:107074	BioGRID:116691	NCOA6	BioGRID	PubMed	Reconstituted Complex
BioGRID:107074	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
BioGRID:107074	BioGRID:110858	NFKB2	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:107074	BioGRID:114114	PIR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:111662	PSMB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:116796	RCOR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:111903	RELB	BioGRID	PubMed	Co-localization
BioGRID:107074	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:112168	RXRA	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107074	BioGRID:112649	STAT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107074	BioGRID:122834	TBL1XR1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107074	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107074	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding, bridging	TAS Traceable Author Statement more info	PubMed
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
I-kappaB kinase/NF-kappaB cascade	IDA Inferred from Direct Assay more info	PubMed
T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info
antimicrobial humoral response	IEA Inferred from Electronic Annotation more info
defense response to bacterium	IEA Inferred from Electronic Annotation more info
defense response to protozoan	IEA Inferred from Electronic Annotation more info
extracellular matrix organization	IEA Inferred from Electronic Annotation more info
follicular dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
germinal center formation	IEA Inferred from Electronic Annotation more info
humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
maintenance of protein location in nucleus	NAS Non-traceable Author Statement more info	PubMed
marginal zone B cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-8 biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor biosynthetic process	IEA Inferred from Electronic Annotation more info
positive regulation of interferon-gamma production	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-10 biosynthetic process	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
protein import into nucleus, translocation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of DNA binding	IEP Inferred from Expression Pattern more info	PubMed
regulation of NF-kappaB import into nucleus	IEP Inferred from Expression Pattern more info	PubMed
regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
response to UV-C	IDA Inferred from Direct Assay more info	PubMed
response to virus	IDA Inferred from Direct Assay more info	PubMed
spleen development	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Bcl3-Bcl10 complex	IDA Inferred from Direct Assay more info	PubMed
Bcl3/NF-kappaB2 complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	NAS Non-traceable Author Statement more info	PubMed
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
protein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: B-cell lymphoma 3 protein

Names: B-cell lymphoma 3 protein; BCL-3; proto-oncogene BCL3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3-encoded protein; chronic lymphatic leukemia protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005178.4 → NP_005169.2 B-cell lymphoma 3 protein

Status: REVIEWED

Source sequence(s)

BC064993, BU501187

Consensus CDS

CCDS12642.2

UniProtKB/Swiss-Prot

P20749

Related

ENSP00000164227, OTTHUMP00000200151, ENST00000164227, OTTHUMT00000322976

Conserved Domains (3) summary

cd00204
Location:237 – 359
Blast Score: 276

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

PHA02736
Location:123 – 179
Blast Score: 107

PHA02736; Viral ankyrin protein; Provisional

pfam12796
Location:246 – 339
Blast Score: 209

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

45251978..45263301

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

41684123..41695446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC092066.4 (85440..96709)	None
genomic	CH471126.1	EAW57291.1
genomic	M31731.1	AAA51816.1
genomic	Z15098.1	None
mRNA	AK296180.1	BAH12275.1
mRNA	AK309453.1	None
mRNA	BC064993.1	AAH64993.1
mRNA	BU501187.1	None
mRNA	M31732.1	AAA51815.1