Format

Send to:

Choose Destination

RGS10 regulator of G-protein signaling 10 [ Homo sapiens (human) ]

Gene ID: 6001, updated on 26-May-2016
Official Symbol
RGS10provided by HGNC
Official Full Name
regulator of G-protein signaling 10provided by HGNC
Primary source
HGNC:HGNC:9992
See related
Ensembl:ENSG00000148908 HPRD:04172; MIM:602856; Vega:OTTHUMG00000019150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
10q25
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (119499827..119542710, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121259339..121302222, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene microRNA 4681 Neighboring gene uncharacterized LOC105378510 Neighboring gene uncharacterized LOC105378512 Neighboring gene TIA1 cytotoxic granule-associated RNA binding protein-like 1 Neighboring gene RAD1 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
regulator of G-protein signaling 10
Names
regulator of G-protein signalling 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005339.1NP_001005339.1  regulator of G-protein signaling 10 isoform a

    See identical proteins and their annotated locations for NP_001005339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI219612, AL547312, BC009361, BF685740, BG763741, BM782346, BM914660, CB112318, CB124184
    Consensus CDS
    CCDS31294.1
    UniProtKB/Swiss-Prot
    O43665
    Related
    ENSP00000358099, OTTHUMP00000020597, ENST00000369103, OTTHUMT00000050654
    Conserved Domains (1) summary
    cd08741
    Location:42154
    RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein
  2. NM_002925.3NP_002916.1  regulator of G-protein signaling 10 isoform b

    See identical proteins and their annotated locations for NP_002916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI219612, AV707839, BC009361, BF685740, BM914660
    Consensus CDS
    CCDS41572.1
    UniProtKB/Swiss-Prot
    O43665
    Related
    ENSP00000376605, ENST00000392865
    Conserved Domains (1) summary
    cd08741
    Location:28140
    RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    119499827..119542710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    121543774..121586656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)