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    RGS3 regulator of G-protein signaling 3 [ Homo sapiens ]

    Gene ID: 5998, updated on 11-May-2012
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    Summary

    Official Symbol
    RGS3provided by HGNC
    Official Full Name
    regulator of G-protein signaling 3provided by HGNC
    Primary source
    HGNC:9999
    Locus tag
    RP11-168K11.4
    See related
    Ensembl:ENSG00000138835; HPRD:03720; MIM:602189; Vega:OTTHUMG00000021048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2PA; RGP3; PDZ-RGS3; FLJ20370; FLJ31516; FLJ90496
    Summary
    This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q32
    Sequence :
    Chromosome: 9; NC_000009.11 (116207011..116360018)
    See RGS3 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene aminolevulinate dehydratase Neighboring gene chromosome 9 open reading frame 43 Neighboring gene polymerase (DNA directed), epsilon 3, accessory subunit Neighboring gene chromosome 14 open reading frame 119 pseudogene Neighboring gene KIAA1586 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function. Rezabkova L, et al. J Biol Chem, 2011 Dec 16. PMID 22027839.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.

    See all (39) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results suggest that the 14-3-3 protein binding affects the structure of the Galpha interaction portion of RGS3 as well as sterically blocks the interaction between the RGS domain and the Galpha subunit of heterotrimeric G proteins.
      Title: Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
    4. 14-3-3 protein binding induces structural changes in both the N-terminal part and the C-terminal RGS domain of phosphorylated RGS3 molecule
      Title: 14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).
    5. Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure.
      Title: Genomic assessment of follicular marker genes as pregnancy predictors for human IVF.
    6. in apoptosis-initiated cells, the ligand-dependent C5aR-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal.
      Title: Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase.
    7. This study identifies a novel, noncanonical role of RGS3 in regulation of TGF-beta signaling through its interaction with Smads and interfering with Smad heteromerization.
      Title: Regulation of Smad-mediated gene transcription by RGS3.
    8. mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel.
      Title: Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.
    9. Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R.
      Title: Muscarinic modulation of Cav2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3T.
    10. RFS3 promoted the conversion of more stable Ca2+ elevations into oscillatory signals.
      Title: Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P49796 Q8WXI2 CNKSR2    HPRD  PubMed  
    P49796 P98172 EFNB1    HPRD  PubMed  
    P49796 P52799 EFNB2    HPRD  PubMed  
    P49796 P03372 ESR1    HPRD  PubMed  
    P49796 Q9UI32 GLS2    HPRD  PubMed  
    P49796 P29992 GNA11    HPRD  PubMed  
    P49796 P08754 GNAI3    HPRD  PubMed  
    P49796 Q12879 GRIN2A    HPRD  PubMed  
    P49796 Q9H422 HIPK3    HPRD  PubMed  
    P49796 P53778 MAPK12    HPRD  PubMed  
    P49796 O60260 PARK2    HPRD  PubMed  
    P49796 P26367 PAX6    HPRD  PubMed  
    P49796 P49796 RGS3    HPRD  PubMed  
    P49796 Q14524 SCN5A    HPRD  PubMed  
    P49796 P31946 YWHAB    HPRD  PubMed  
    P49796 P62258 YWHAE    HPRD  PubMed  
    P49796 P27348 YWHAQ    HPRD  PubMed  
    P49796 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:111930 BioGRID:109029 GNA11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111930 BioGRID:109035 GNAI3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111930 BioGRID:109871 IRF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111930 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111930 BioGRID:247522 Nedd4    BioGRID  PubMed Biochemical Activity 
    BioGRID:111930 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111930 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111930 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111930 BioGRID:204619 Ywhae    BioGRID  PubMed Two-hybrid 
    BioGRID:111930 BioGRID:204622 Ywhaq    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    inactivation of MAPK activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of G-protein coupled receptor protein signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    termination of G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
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    General protein information

    Preferred Names
    regulator of G-protein signaling 3
    Names
    regulator of G-protein signaling 3
    regulator of G-protein signalling 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029512.1 RefSeqGene

      Range
      5001..158008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_017790.3 → NP_060260.3  regulator of G-protein signaling 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons, and contains alternate 5' and 3' coding regions as compared to variant 6. Isoform 3 has shorter and distinct N- and C-termini, as compared to isoform 6.
      Source sequence(s)
      AK000377, AK074977, AK125059, AK128127
      Consensus CDS
      CCDS35113.1
      UniProtKB/TrEMBL
      B3KWG8
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      Q9NX91
      Related
      ENSP00000312844, OTTHUMP00000022813, ENST00000317613, OTTHUMT00000055562
      Conserved Domains (2) summary
      cd00992
      Location:188 – 260
      Blast Score: 156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08685
      Location:27 – 146
      Blast Score: 536
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

    2. NM_021106.3 → NP_066929.1  regulator of G-protein signaling 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 5' exons and contains an alternate 5' end as compared to variant 6. Isoform 2 has a much shorter N-terminus as compared to isoform 6.
      Source sequence(s)
      AF006609, AF463495, BC019039
      Consensus CDS
      CCDS6798.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      Q8WV02
      Related
      ENSP00000363249, OTTHUMP00000022815, ENST00000374134, OTTHUMT00000055567
      Conserved Domains (2) summary
      PHA03307
      Location:1 – 173
      Blast Score: 115
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08713
      Location:395 – 508
      Blast Score: 535
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    3. NM_130795.2 → NP_570613.2  regulator of G-protein signaling 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as PDZ-RGS3, contains an alternate 5' coding region, as compared to variant 6. Isoform 1 has a shorter and distinct N-terminus compared to isoform 6.
      Source sequence(s)
      AF463495, AF490840, BC019039, BC042555
      Consensus CDS
      CCDS6797.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      Q8WV02
      Related
      ENSP00000340284, OTTHUMP00000022814, ENST00000343817, OTTHUMT00000055566
      Conserved Domains (3) summary
      cd00992
      Location:17 – 91
      Blast Score: 169
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PHA03307
      Location:397 – 571
      Blast Score: 127
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08713
      Location:793 – 906
      Blast Score: 539
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    4. NM_134427.1 → NP_602299.1  regulator of G-protein signaling 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple 5' exons and contains an alternate 5' UTR, as compared to variant 6. Isoform 4 has a much shorter N-terminus, as compared to isoform 6.
      Source sequence(s)
      AL162727
      UniProtKB/TrEMBL
      H7BXY1
      Related
      ENSP00000343359, ENST00000342620
      Conserved Domains (1) summary
      cd08713
      Location:44 – 157
      Blast Score: 492
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    5. NM_144488.4 → NP_652759.3  regulator of G-protein signaling 3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as C2PA-RGS3, encodes the longest isoform (6).
      Source sequence(s)
      AK128127, BC019039
      Consensus CDS
      CCDS43869.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      Q8WV02
      Related
      ENSP00000363255, OTTHUMP00000022812, ENST00000374140, OTTHUMT00000055561
      Conserved Domains (4) summary
      cd00992
      Location:300 – 372
      Blast Score: 162
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08685
      Location:139 – 258
      Blast Score: 544
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      PHA03307
      Location:678 – 852
      Blast Score: 129
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08713
      Location:1074 – 1187
      Blast Score: 542
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    6. NM_144489.2 → NP_652760.2  regulator of G-protein signaling 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as RGS3S, lacks multiple 5' exons and contains an alternate 5' coding exon, as compared to variant 6. Isoform 5 has a shorter and distinct N-terminus as compared to isoform 6.
      Source sequence(s)
      AL162727, BC019039
      Consensus CDS
      CCDS35114.1
      UniProtKB/TrEMBL
      Q5VZ06
      UniProtKB/TrEMBL
      Q8WV02
      Related
      ENSP00000436168, OTTHUMP00000233952, ENST00000462403, OTTHUMT00000055568
      Conserved Domains (1) summary
      cd08713
      Location:187 – 300
      Blast Score: 531
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      116207011..116360018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      85813935..85966657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF006610.1 None
    genomic AL137066.15 CAH70102.1
      CAH70103.1
    genomic AL162727.20 CAC78977.1
      CAH70841.1
      CAH70842.2
      CAH70843.1
    genomic AL162727.20 CAC78977.1
      CAH70841.1
      CAH70842.2
      CAH70843.1
    genomic AL359455.22 CAH73877.1
      CAH73878.1
      CAH73879.1
      CAH73880.1
    genomic CH471090.1 EAW87387.1
      EAW87388.1
      EAW87389.1
      EAW87390.1
      EAW87391.1
      EAW87392.1
      EAW87393.1
      EAW87394.1
      EAW87395.1
      EAW87396.1
      EAW87397.1
      EAW87398.1
    mRNA AF006609.1 AAB62725.1
    mRNA AF463495.1 AAL68829.1
    mRNA AF490838.1 AAM33253.1
    mRNA AF490839.1 AAM33254.1
    mRNA AF490840.1 AAM33255.1
    mRNA AF493927.1 AAM12641.1
    mRNA AF493941.1 AAM12655.1
    mRNA AK000377.1 BAA91125.1
    mRNA AK054584.1 BAB70766.1
    mRNA AK074977.1 BAC11328.1
    mRNA AK096840.1 BAG53374.1
    mRNA AK123387.1 BAG53899.1
    mRNA AK125059.1 BAG54130.1
    mRNA AK125094.1 BAC86049.1
    mRNA AK128127.1 BAC87285.1
    mRNA AK222888.1 BAD96608.1
    mRNA AK226153.1 None
    mRNA AK289666.1 BAF82355.1
    mRNA AK301515.1 BAG63021.1
    mRNA AK310705.1 None
    mRNA AY585192.1 AAT79495.1
    mRNA BC018072.1 AAH18072.2
    mRNA BC019039.2 AAH19039.3
    mRNA BC042555.1 AAH42555.1
    mRNA U27655.1 AAC50394.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49796.2 GenPept UniProtKB/Swiss-Prot:P49796
    Q53GP3 GenPept UniProtKB/TrEMBL:Q53GP3
    Q5VXC0 GenPept UniProtKB/TrEMBL:Q5VXC0
    Q5VZ06 GenPept UniProtKB/TrEMBL:Q5VZ06
    Q6ZV17 GenPept UniProtKB/TrEMBL:Q6ZV17
    Q8NFN6 GenPept UniProtKB/TrEMBL:Q8NFN6
    Q8WV02 GenPept UniProtKB/TrEMBL:Q8WV02
    Q8WVE9 GenPept UniProtKB/TrEMBL:Q8WVE9
    Q96NV5 GenPept UniProtKB/TrEMBL:Q96NV5
    Q9NX91 GenPept UniProtKB/TrEMBL:Q9NX91
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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