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    TRIM27 tripartite motif containing 27 [ Homo sapiens ]

    Gene ID: 5987, updated on 11-May-2012
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    Summary

    Official Symbol
    TRIM27provided by HGNC
    Official Full Name
    tripartite motif containing 27provided by HGNC
    Primary source
    HGNC:9975
    Locus tag
    DAAP-182E11.3
    See related
    Ensembl:ENSG00000204713; HPRD:15996; MIM:602165; Vega:OTTHUMG00000031215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RFP; RNF76
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p22
    Sequence :
    Chromosome: 6; NC_000006.11 (28870779..28891768, complement)
    See TRIM27 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC401242 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene zinc finger protein 90 pseudogene 2 Neighboring gene chromosome 6 open reading frame 100 Neighboring gene keratin 18 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Cai X, et al. Proc Natl Acad Sci U S A, 2011 Dec 13. PMID 22128329.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Kahle JJ, et al. Hum Mol Genet, 2011 Feb 1. PMID 21078624.
    5. SUMO E3 ligase activity of TRIM proteins. Chu Y, et al. Oncogene, 2011 Mar 3. PMID 20972456.

    See all (42) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells.
      Title: Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    3. Our study is the first in the literature to show expression of RET finger protein in patients with breast carcinoma
      Title: RET finger protein expression in invasive breast carcinoma: relationship between RFP and ErbB2 expression.
    4. RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs.
      Title: The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.
    5. Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription.
      Title: Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.
    6. RFP selectively ablates Rb function.
      Title: Selective ablation of retinoblastoma protein function by the RET finger protein.
    7. role in inducing apoptosis via its RING finger-B box-coiled-coil motif
      Title: The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif.
    8. the amino-terminal and carboxyl-terminal regions of Mi-2 beta have distinct transcriptional activities and bind to BRG1 and the RET finger protein, forming a multiprotein supercomplex involved in transcriptional regulation.
      Title: Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P14373 Brain enriched guanylate kinase associated protein BEGAIN    HPRD  PubMed  
    P14373 Q14839 CHD4    HPRD  PubMed  
    P14373 P26358 DNMT1    HPRD  PubMed  
    P14373 EID1 EID1    HPRD  PubMed  
    P14373 P60228 EIF3E    HPRD  PubMed  
    P14373 Q9H2F5 EPC1    HPRD  PubMed  
    P14373 Fas binding protein 1 FBF1    HPRD  PubMed  
    P14373 Q9H0Q3 FXYD6    HPRD  PubMed  
    P14373 Growth factor independent 1B GFI1B    HPRD  PubMed  
    P14373 Q13547 HDAC1    HPRD  PubMed  
    P14373 Q96SI1 KCTD15    HPRD  PubMed  
    P14373 P43364 MAGEA11    HPRD  PubMed  
    P14373 Q9GZU1 MCOLN1    HPRD  PubMed  
    P14373 P29590 PML    HPRD  PubMed  
    P14373 Q96QH2 PRAM1    HPRD  PubMed  
    P14373 P06400 RB1    HPRD  PubMed  
    P14373 Q96F44 TRIM11    HPRD  PubMed  
    P14373 P36406 TRIM23    HPRD  PubMed  
    P14373 P14373 TRIM27    HPRD  PubMed  
    P14373 Q14134 TRIM29    HPRD  PubMed  
    P14373 Q05516 ZBTB16    HPRD  PubMed  
    BioGRID:111919 BioGRID:112221 ATXN7    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:121647 BEGAIN    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:108123 DNMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:109857 EIF3E    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:124465 FBF1    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:120078 FBXL19    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:119799 FXYD6    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:109217 GTF2F1    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111919 BioGRID:120917 HR    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:110284 MAGEA11    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:123521 MAGED4B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111919 BioGRID:122067 MAGEF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111919 BioGRID:120036 MAGEL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111919 BioGRID:114445 MBD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111919 BioGRID:119788 MBD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111919 BioGRID:114444 MBD4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111919 BioGRID:121441 MCOLN1    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111919 BioGRID:114807 MED21    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:110868 NFYC    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111919 BioGRID:114124 PIAS1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:114523 PIAS2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:115673 PIAS3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:119624 PIAS4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111919 BioGRID:123894 PRAM1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111919 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111919 BioGRID:123523 TRIM11    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:106868 TRIM23    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:117177 TRIM29    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:116608 TRIM32    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111919 BioGRID:113167 UBE2A    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113176 UBE2H    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111919 BioGRID:119555 UBE2J1    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:109340 UBE2K    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:114672 UBE2L6    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:121973 UBE2O    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:118858 UBE2T    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:122419 UBE2Z    BioGRID  PubMed Two-hybrid 
    BioGRID:111919 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transmembrane receptor protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein trimerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    zinc finger protein RFP
    Names
    zinc finger protein RFP
    ret finger protein
    RING finger protein 76
    RFP transforming protein
    tripartite motif-containing 27
    tripartite motif protein TRIM27
    tripartite motif-containing protein 27
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006510.4 → NP_006501.1  zinc finger protein RFP

      Status: REVIEWED

      Source sequence(s)
      AL662871, BC013580
      Consensus CDS
      CCDS4654.1
      UniProtKB/Swiss-Prot
      P14373
      Related
      ENSP00000366404, OTTHUMP00000029314, ENST00000377199, OTTHUMT00000076442
      Conserved Domains (5) summary
      cd00021
      Location:95 – 132
      Blast Score: 116
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 – 60
      Blast Score: 107
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:12 – 58
      Blast Score: 103
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:369 – 492
      Blast Score: 354
      SPRY; SPRY domain
      cl02686
      Location:315 – 366
      Blast Score: 231
      PRY; SPRY-associated domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      28870779..28891768, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p5 ALT_REF_LOCI_1

      Range
      174180..195170, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      393803..414796, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      191190..195170, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      174342..195331, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      174180..195169, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      211702..232682, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      28678679..28699726, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030950.2: Suppressed sequence

      Description
      NM_030950.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF171101.1 AAF32265.1
    genomic AL662859.5 (37056..58049) None
    genomic AL662871.9 (38890..59880) None
    genomic BX000360.7 CAI18618.1
      CAI18619.1
    genomic BX005144.14 CAM25871.1
      CAM25872.1
    genomic BX119924.8 CAM26230.1
      CAM26231.1
    genomic BX537153.6 CAI18645.1
      CAI18646.1
    genomic CH471081.1 EAX03176.1
      EAX03177.1
    genomic CR759942.12 CAQ07942.1
      CAQ07943.1
    genomic CR936876.2 CAQ09162.1
      CAQ09163.1
      CAQ09164.1
    genomic CR936883.15 None
    genomic CR936965.7 CAQ10095.1
    genomic Z84474.1 CAB06480.2
    genomic Z84476.7 CAI19959.1
    mRNA AB209885.1 BAD93122.1
    mRNA AF230393.1 AAG50172.1
    mRNA AF230394.1 AAG50173.1
    mRNA AJ420519.1 None
    mRNA AX776009.1 CAE11704.1
    mRNA AX776011.1 CAE11705.1
    mRNA BC013580.1 AAH13580.1
    mRNA BC066924.1 AAH66924.1
    mRNA J03407.1 AAA36564.1
    other-genetic DQ890982.2 ABM81908.1
    other-genetic DQ894156.2 ABM85082.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14373.1 GenPept UniProtKB/Swiss-Prot:P14373
    Q59EC6 GenPept UniProtKB/TrEMBL:Q59EC6
    Q9NZT8 GenPept UniProtKB/TrEMBL:Q9NZT8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Molecular Biology Databases
    Research Materials
    Miscellaneous

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