RELB v-rel reticuloendotheliosis viral oncogene homolog B [Homo sapiens (human)] - Gene

Summary

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Official Symbol: RELBprovided by HGNC
Official Full Name: v-rel reticuloendotheliosis viral oncogene homolog Bprovided by HGNC
Primary source: HGNC:9956
See related: Ensembl:ENSG00000104856; HPRD:06886; MIM:604758; Vega:OTTHUMG00000162116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IREL; I-REL; REL-B

Genomic context

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Location :: 19q13.32

Sequence :: Chromosome: 19; NC_000019.9 (45504707..45541456)

See RELB in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kaposi's sarcoma-associated herpesvirus oncoprotein K13 upregulated the expression of NF-kappaB subunit RelB and blocked the anti-IgM-induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis.
Title: Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation.
The expression of RelB negatively regulates the endogenous expression of maspin in prostate cancer cells in vitro.
Title: [NF-κB subunits regulate maspin expression in prostate cancer cells in vitro].
The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression.
Title: The RelB subunit of NFκB acts as a negative regulator of circadian gene expression.
These data show that Hodgkin lymphoma is uniquely dependent on relB
Title: Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival.
RelB/NF-kappaB2, is constitutively activated in the human placenta, which binds to a previously undescribed NF-kappaB enhancer of corticotropin-releasing hormone (CRH) gene promoter to regulate CRH expression.
Title: RelB/NF-κB2 regulates corticotropin-releasing hormone in the human placenta.
women entering labor exhibit low or moderate NFkappaB activition, the process does not appear to involve classical pathways of NFkappaB activation but rather is correlated with an increase in nuclear p65-Rel-B dimers.
Title: Nuclear factor kappa B activation occurs in the amnion prior to labour onset and modulates the expression of numerous labour associated genes.
RelB is a CO(2)-sensitive NF-kappaB family member that may contribute to the beneficial effects of hypercapnia in inflammatory diseases of the lung
Title: Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling.
RelB plays a critical role in the response of PCa to radiotherapy and the inverse expression of IL-8 and PSA
Title: Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-κB-mediated mechanism.
Nuclear factor kappaB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated beta-interferon production via induction of transcriptional repressor protein YY1.
Title: Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1.
We propose that RelB is an essential molecule controlling the endogenous and the proteasome inhibitor-induced Maspin expression.
Title: Maspin expression is regulated by the non-canonical NF-κB subunit in androgen-insensitive prostate cancer cell lines.

Submit: New GeneRIF Correction See all (45)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	NFkappaB tethers the p160 nuclear receptor co-activator GRIP1 to the HIV-1 LTR promoter, thereby regulating the full activation of this promoter by HIV-1 Tat	PubMed
	tat	HIV-1 Tat has been shown to bind NFkappaB in vitro in gel shift, GST-pull down and affinity matrix assays	PubMed
	tat	NFAT-1 negatively regulates HIV-1 Tat-mediated transactivation of the HIV-1 LTR by competing with NFkappaB for its binding to the LTR, thereby blocking the interaction of NFkappaB with Tat	PubMed
	tat	HIV-1 Tat enhances tumor necrosis factor-induced activation of NFkappaB by downregulating manganese-dependent superoxide dismutase (MnSOD)	PubMed
	tat	HIV-1 Tat activates NFkappaB through the cellular interferon-inducible, double-stranded RNA dependent protein kinase, PKR	PubMed
	tat	p56-lck plays a critical role in the activation of NFkappaB by HIV-1 Tat	PubMed
	tat	Activation of NFkappaB by HIV-1 Tat leads to a reduction in adenylyl cyclase activity and an inhibition of cAMP synthesis	PubMed
	tat	Activation of NFkappaB by HIV-1 Tat is inhibited by Nitric Oxide	PubMed
	tat	HIV-1 Tat activates NFkappaB, causing the induction of CD95 ligand, CD69, iNOS, MCP-1, IL-2, IL-6, IL-8, IL-10, TNF-alpha, VCAM-1, ICAM-1, E-selectin, and MMP-9, as well as monocyte adhesion, cellular activation and angiogenesis	PubMed
	tat	HIV-1 Tat-mediated transcriptional activation of the HIV-1 LTR promoter requires NFkappaB binding sites in the promoter and involves the activation of NFkappaB by Tat	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q01201	Q4VC05	BCL7A	HPRD	PubMed
Q01201	Q92785	DPF2	HPRD	PubMed
Q01201	Q9UBN7	HDAC6	HPRD	PubMed
Q01201	P52292	KPNA2	HPRD	PubMed
Q01201	O60684	KPNA6	HPRD	PubMed
Q01201	P19838	NFKB1	HPRD	PubMed
Q01201	Q00653	NFKB2	HPRD	PubMed
Q01201	Q04206	RELA	HPRD	PubMed
Q01201	P51532	SMARCA4	HPRD	PubMed
Q01201	Q12824	SMARCB1	HPRD	PubMed
Q01201	Q92922	SMARCC1	HPRD	PubMed
Q01201	Q8TAQ2	SMARCC2	HPRD	PubMed
Q01201	Q969G3	SMARCE1	HPRD	PubMed
Q01201	P51784	USP11	HPRD	PubMed
BioGRID:111903	BioGRID:106601	ACTL6A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:107074	BCL3	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:111903	BioGRID:107077	BCL7A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:114413	BUD31	BioGRID	PubMed	Two-hybrid
BioGRID:111903	BioGRID:116463	CBX3	BioGRID	PubMed	Co-localization
BioGRID:111903	BioGRID:107420	CDK1	BioGRID	PubMed	Two-hybrid
BioGRID:111903	BioGRID:127317	COMMD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:119521	COMMD10	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:119309	COMMD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:120279	COMMD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:118812	COMMD5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:120289	COMMD8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:118867	COMMD9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:107894	CTSL1	BioGRID	PubMed	Two-hybrid
BioGRID:111903	BioGRID:107985	DAXX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:111909	DPF2	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:111903	BioGRID:116123	EHMT2	BioGRID	PubMed	Co-localization; Reconstituted Complex
BioGRID:111903	BioGRID:108446	EZH2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111903	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:111903	BioGRID:109315	HDAC1	BioGRID	PubMed	Co-localization
BioGRID:111903	BioGRID:115330	HDAC6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:119613	HDAC7	BioGRID	PubMed	Negative Genetic
BioGRID:111903	BioGRID:110036	KPNA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:117163	KPNA6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:116098	MALT1	BioGRID	PubMed	Biochemical Activity
BioGRID:111903	BioGRID:110605	MT1M	BioGRID	PubMed	Two-hybrid
BioGRID:111903	BioGRID:110611	MTAP	BioGRID	PubMed	Two-hybrid
BioGRID:111903	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
BioGRID:111903	BioGRID:110858	NFKB2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-localization
BioGRID:111903	BioGRID:110859	NFKBIA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:111817	RAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111903	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:112482	SMARCB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:112483	SMARCC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:112485	SMARCC2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:112489	SMARCE1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:117059	SUZ12	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111903	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111903	BioGRID:113232	UQCRFS1	BioGRID	PubMed	Two-hybrid
BioGRID:111903	BioGRID:113866	USP11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111903	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Alternative NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
Alternative NF-kappaB pathway, organism-specific biosystem
Alternative NF-kappaB pathway
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL12-mediated signaling events, organism-specific biosystem
IL12-mediated signaling events
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
RANKL/RANK Signaling Pathway, organism-specific biosystem (from WikiPathways)
RANKL/RANK Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
TSLP Signaling Pathway, organism-specific biosystem (from WikiPathways)
TSLP Signaling Pathway, organism-specific biosystemThymic stromal lymphopoietin (TSLP) is a type I cytokine member of interleukin-2 cytokine family. TSLP signals through interleukin-7 receptor a chain (IL-7Ra) and the TSLP receptor subunit (TSLPR), h...
TWEAK Signaling Pathway, organism-specific biosystem (from WikiPathways)
TWEAK Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...

General gene information

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Homology

Homologs of the RELB gene: The RELB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
transcription corepressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
T-helper 1 cell differentiation	IEA Inferred from Electronic Annotation more info
antigen processing and presentation	IEA Inferred from Electronic Annotation more info
myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytosol	IEA Inferred from Electronic Annotation more info
microtubule organizing center	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor RelB

Names: transcription factor RelB; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006509.3 → NP_006500.2 transcription factor RelB

Status: VALIDATED

Source sequence(s)

BC028013, BM684710, DA940587

Consensus CDS

CCDS46110.1

UniProtKB/Swiss-Prot

Q01201

Related

ENSP00000221452, OTTHUMP00000221312, ENST00000221452, OTTHUMT00000367361

Conserved Domains (2) summary

cd01177
Location:303 – 399
Blast Score: 374

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd07886
Location:125 – 296
Blast Score: 866

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p10 Primary Assembly

Range

45504707..45541456

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

41935689..41971666

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018930.1 Alternate CHM1_1.0

Range

45695064..45731089

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01040900.1	None
genomic	ABBA01040901.1	None
genomic	ABBA01040902.1	None
genomic	ABBA01040903.1	None
genomic	ABBA01040904.1	None
genomic	ABBA01040905.1	None
genomic	ABBA01040906.1	None
genomic	ABBA01040907.1	None
genomic	AC011489.6 (29956..66696)	None
genomic	AF043463.1	AAC82346.1
genomic	AMYH01009847.1 (63294..99319)	None
genomic	CH471126.1	EAW57316.1
genomic	DQ314887.1	ABC40746.1
mRNA	AK290594.1	BAF83283.1
mRNA	AL583128.3	None
mRNA	AW137991.1	None
mRNA	BC028013.1	AAH28013.1
mRNA	BI906507.1	None
mRNA	BM684710.1	None
mRNA	DA940587.1	None
mRNA	M83221.1	AAA36127.1