RBP4 retinol binding protein 4, plasma [Homo sapiens] - Gene

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Summary

Official Symbol: RBP4provided by HGNC
Official Full Name: retinol binding protein 4, plasmaprovided by HGNC
Primary source: HGNC:9922
Locus tag: PRO2222
See related: Ensembl:ENSG00000138207; HPRD:01580; MIM:180250; Vega:OTTHUMG00000018773
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 10q23-q24

Sequence :: Chromosome: 10; NC_000010.10 (95351593..95360993, complement)

See RBP4 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the increase of apo-/holo-RBP4 concentration may influence STRA6 signaling, finally causing apoptosis.
Title: Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling.
The elevation of RBP4 levels in polycystic ovary syndrome women might be influenced by androgen hormones.
Title: The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome.
This review summarizes up-to-date knowledge of RBP4's controversial role as an adipokine linked to obesity, development of insulin resistance, and type 2 diabetes.
Title: RBP4: a controversial adipokine.
serum level decreased in psoriasis
Title: Leptin, adiponectin, visfatin and retinol-binding protein-4 - mediators of comorbidities in patients with psoriasis?
RBP(4) has been shown to induce insulin resistance, and plasma RBP(4) values are increased in type 2 diabetes mellitus, obesity, metabolic syndrome, and cardiovascular disease.
Title: The metabolic role of retinol binding protein 4: an update.
RBP4 may have a role in insulin resistance and risk for type 2 diabetes and metabolic syndrome
Title: Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay.
We verified the decrease of RBP4 levels in ovarian cancer patient sera by two independent methods.
Title: Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: a potential biomarker identified by proteomics.
A higher degree of IR in the GDM group compared with the non-GDM group, but serum RBP4 levels between the 2 groups were not different.
Title: Retinol-binding protein 4 is not associated with insulin resistance in pregnancy.
The elevated expression of RBP4 in subcutaneous adipose tissue may contribute to the increase in circulating RBP4 in gestational diabetes subjects.
Title: Retinol-binding protein 4 in adipose and placental tissue of women with gestational diabetes.
genetic association studies in population of children in Germany: Data suggest that SNP in promoter region of RBP4 (-803G>A; rs3758539) is not associated with overweight/obesity, type 2 diabetes, or hypertension in Caucasian children.
Title: The promoter variant -803 G>A in the RBP4 gene is not associated with BMI, metabolic parameters or blood pressure in Caucasian children.

Submit: New GeneRIF Correction See all (150)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Retinol binding protein, deficiency of

MIM: 180250

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Products	Interactant	Other Gene	Source	Pubs	Description
P02753	P02768	ALB	HPRD	PubMed
P02753	Q16518	RPE65	HPRD	PubMed
P02753	P02766	TTR	HPRD	PubMed
BioGRID:111884	BioGRID:109142	GRB2	BioGRID	PubMed	Two-hybrid
BioGRID:111884	BioGRID:111865	RBBP6	BioGRID	PubMed	Two-hybrid
BioGRID:111884	BioGRID:113127	TTR	BioGRID	PubMed	Co-purification

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
retinal binding	IEA Inferred from Electronic Annotation more info
retinol binding	IDA Inferred from Direct Assay more info	PubMed
retinol transporter activity	IC Inferred by Curator more info	PubMed
transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cardiac muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
detection of light stimulus involved in visual perception	IEA Inferred from Electronic Annotation more info
embryo development	IEA Inferred from Electronic Annotation more info
embryonic organ morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
embryonic retina morphogenesis in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
embryonic skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
eye development	IMP Inferred from Mutant Phenotype more info	PubMed
eye development	ISS Inferred from Sequence or Structural Similarity more info
female genitalia morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
heart development	ISS Inferred from Sequence or Structural Similarity more info
heart trabecula formation	ISS Inferred from Sequence or Structural Similarity more info
lung development	ISS Inferred from Sequence or Structural Similarity more info
maintenance of gastrointestinal epithelium	IDA Inferred from Direct Assay more info	PubMed
male gonad development	IEA Inferred from Electronic Annotation more info
negative regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of immunoglobulin secretion	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
response to ethanol	IEA Inferred from Electronic Annotation more info
response to insulin stimulus	IEA Inferred from Electronic Annotation more info
response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
response to stimulus	IEA Inferred from Electronic Annotation more info
retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
retinal metabolic process	IEA Inferred from Electronic Annotation more info
retinol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
retinol transport	IC Inferred by Curator more info	PubMed
spermatogenesis	IEA Inferred from Electronic Annotation more info
transmembrane transport	IEA Inferred from Electronic Annotation more info
urinary bladder development	ISS Inferred from Sequence or Structural Similarity more info
uterus development	ISS Inferred from Sequence or Structural Similarity more info
vagina development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: retinol-binding protein 4

Names: retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009104.1 RefSeqGene

Range

5001..14401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006744.3 → NP_006735.2 retinol-binding protein 4 precursor

Status: REVIEWED

Source sequence(s)

BC020633, BX495987, X00129

Consensus CDS

CCDS31249.1

UniProtKB/Swiss-Prot

P02753

Related

ENSP00000360519, OTTHUMP00000020114, ENST00000371464, OTTHUMT00000049429

Conserved Domains (1) summary

cl01150
Location:39 – 179
Blast Score: 187

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

95351593..95360993, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

88979353..88988753, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF025334.1	AAC02945.1
genomic	AF025335.1	AAC02946.1
genomic	AL356214.20	CAH72328.1
		CAH72329.1
genomic	AL356214.20	CAH72328.1
		CAH72329.1
genomic	CH471066.2	EAW50065.1
		EAW50066.1
		EAW50067.1
		EAW50068.1
genomic	X02775.1	CAA26553.1
genomic	X02824.1	CAB46489.1
mRNA	BC020633.1	AAH20633.1
mRNA	BX495987.1	None
mRNA	X00129.1	CAA24959.1
other-genetic	DQ891381.2	ABM82307.1
other-genetic	DQ894558.2	ABM85484.1