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plat plasminogen activator, tissue [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 594962, updated on 5-Mar-2024

Summary

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Official Symbol
platprovided by Xenbase
Official Full Name
plasminogen activator, tissueprovided by Xenbase
Primary source
Xenbase:XB-GENE-1010818
See related
Ensembl:ENSXETG00000016792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
15
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (130539912..130560407, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (120191889..120212001, complement)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 6A Neighboring gene adaptor related protein complex 3 subunit mu 2 Neighboring gene inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Neighboring gene voltage-dependent anion channel 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC107814

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within plasminogen activation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tissue-type plasminogen activator
NP_001025574.2
XP_012814580.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030403.2 → NP_001025574.2  tissue-type plasminogen activator precursor

    See identical proteins and their annotated locations for NP_001025574.2

    Status: VALIDATED

    Source sequence(s)
    BC091010, EL841152
    UniProtKB/TrEMBL
    F7A271, Q5BKN3
    Related
    ENSXETP00000036622.4, ENSXETT00000036622.5
    Conserved Domains (3) summary
    smart00130
    Location:219 → 301
    KR; Kringle domain
    cd00190
    Location:317 → 557
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:91 → 123
    EGF; EGF-like domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    130539912..130560407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012959126.3 → XP_012814580.1  tissue-type plasminogen activator isoform X1

    UniProtKB/TrEMBL
    A0A6I8SC94, A0A8J0SHG9
    Related
    ENSXETP00000086013.2, ENSXETT00000094973.2
    Conserved Domains (5) summary
    smart00020
    Location:342 → 582
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:158 → 241
    KR; Kringle domain
    cd00190
    Location:345 → 585
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:119 → 151
    EGF; EGF-like domain
    pfam00051
    Location:247 → 328
    Kringle; Kringle domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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