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Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59266, updated on 17-May-2016
Official Symbol
Hcn4provided by RGD
Official Full Name
hyperpolarization activated cyclic nucleotide-gated potassium channel 4provided by RGD
Primary source
RGD:71065
See related
Ensembl:ENSRNOG00000009450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may act as a neuronal pacemaker channel; may play a role in neurotransmitter release [RGD, Feb 2006]
Orthologs
Location:
8q24
Exon count:
8
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (63599907..63637327)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (63367893..63405313)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene Cd276 molecule Neighboring gene neuroplastin Neighboring gene REC114 meiotic recombination protein Neighboring gene neogenin 1 Neighboring gene uncharacterized LOC103693107

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
intracellular cAMP activated cation channel activity IEA
Inferred from Electronic Annotation
more info
 
intracellular cAMP activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
intracellular cAMP activated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SA node cell action potential IEA
Inferred from Electronic Annotation
more info
 
SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
cation transport ISO
Inferred from Sequence Orthology
more info
 
cellular response to aldosterone IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cGMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
modulation of synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
response to cisplatin IEP
Inferred from Expression Pattern
more info
PubMed 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Names
hyperpolarization-activated, cyclic nucleotide-gated K+ 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021658.1NP_067690.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

    See identical proteins and their annotated locations for NP_067690.1

    Status: PROVISIONAL

    Source sequence(s)
    AF247453
    UniProtKB/Swiss-Prot
    Q9JKA7
    Related
    ENSRNOP00000012644, ENSRNOT00000012644
    Conserved Domains (4) summary
    pfam08412
    Location:217293
    Ion_trans_N; Ion transport protein N-terminal
    COG0664
    Location:589724
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:595703
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:297511
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    63599907..63637327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    58680131..58717545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)