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    ARID4A AT rich interactive domain 4A (RBP1-like) [ Homo sapiens ]

    Gene ID: 5926, updated on 11-May-2012
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    Summary

    Official Symbol
    ARID4Aprovided by HGNC
    Official Full Name
    AT rich interactive domain 4A (RBP1-like)provided by HGNC
    Primary source
    HGNC:9885
    See related
    Ensembl:ENSG00000032219; HPRD:01575; MIM:180201; Vega:OTTHUMG00000140320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBP1; RBBP1; RBP-1; RBBP-1
    Summary
    The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    14q23.1
    Sequence :
    Chromosome: 14; NC_000014.8 (58765222..58840451)
    See ARID4A in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, alpha type, 3 Neighboring gene uncharacterized LOC379025 Neighboring gene high mobility group box 1 pseudogene 14 Neighboring gene translocase of outer mitochondrial membrane 20 homolog (yeast)-like Neighboring gene translocase of inner mitochondrial membrane 9 homolog (yeast) Neighboring gene KIAA0586 Neighboring gene heat shock factor binding protein 1 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1. Gong W, et al. J Biol Chem, 2012 Mar 9. PMID 22247551.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    4. Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex. Suryadinata R, et al. J Biol Chem, 2011 Feb 18. PMID 21148318.
    5. System-wide changes to SUMO modifications in response to heat shock. Golebiowski F, et al. Sci Signal, 2009 May 26. PMID 19471022.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. chromobarrel domain of RBBP1 is responsible for recognizing methylated histone tails in chromatin remodeling and epigenetic regulation
      Title: Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.
    2. Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.
      Title: Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.
    3. RBP1 and the mSin3 histone deacetylase complex bind to BRMS1 and repress transcription
      Title: Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.
    4. there is an E2-dependent, ER isoform-specific transcriptional activation of the RBBP1 gene, which in part, is explained by the differential activity of ER AF1 and enhancer element binding
      Title: Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P29374 Q9HCU9 BRMS1    HPRD  PubMed  
    P29374 EID1 EID1    HPRD  PubMed  
    P29374 Q13547 HDAC1    HPRD  PubMed  
    P29374 Q92769 HDAC2    HPRD  PubMed  
    P29374 O15379 HDAC3    HPRD  PubMed  
    P29374 Q96ST3 SIN3A    HPRD  PubMed  
    BioGRID:111861 BioGRID:119708 ARID4B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:117379 BRMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:107331 CCNA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:107332 CCNB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:107067 CCND1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:107338 CCNE1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:107420 CDK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:107454 CDK4    BioGRID  PubMed Biochemical Activity 
    BioGRID:111861 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:126025 HIST2H3C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111861 BioGRID:125732 HIST4H4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111861 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111861 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111861 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:114346 SAP30    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111861 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:116901 SIN3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111861 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111861 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    AT-rich interactive domain-containing protein 4A
    Names
    AT-rich interactive domain-containing protein 4A
    retinoblastoma binding protein 1
    retinoblastoma-binding protein 1
    ARID domain-containing protein 4A
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002892.3 → NP_002883.3  AT-rich interactive domain-containing protein 4A isoform I

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the full length isoform.
      Source sequence(s)
      AL139021, BC026230, BX279740, DB218466, S57153
      Consensus CDS
      CCDS9732.1
      UniProtKB/Swiss-Prot
      P29374
      UniProtKB/TrEMBL
      Q05CG0
      Related
      ENSP00000347602, OTTHUMP00000179023, ENST00000355431, OTTHUMT00000276927
      Conserved Domains (4) summary
      pfam08169
      Location:168 – 263
      Blast Score: 437
      RBB1NT; RBB1NT (NUC162) domain
      cl02573
      Location:58 – 113
      Blast Score: 117
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cl02633
      Location:314 – 401
      Blast Score: 300
      ARID; ARID/BRIGHT DNA binding domain
      cl15261
      Location:575 – 630
      Blast Score: 171
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

    2. NM_023000.2 → NP_075376.2  AT-rich interactive domain-containing protein 4A isoform II

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks 162 bp in the coding region, as compared to variant 1, but maintains the same reading frame. The encoded protein lacks 54 internal codons and is thought to lack phosphorylation sites.
      Source sequence(s)
      AL139021, BC026230, BX279740, DB218466, S57160
      Consensus CDS
      CCDS45114.1
      UniProtKB/Swiss-Prot
      P29374
      UniProtKB/TrEMBL
      Q05CG0
      Related
      ENSP00000378597, OTTHUMP00000197517, ENST00000395168, OTTHUMT00000318394
      Conserved Domains (4) summary
      pfam08169
      Location:168 – 263
      Blast Score: 438
      RBB1NT; RBB1NT (NUC162) domain
      cl02573
      Location:58 – 113
      Blast Score: 116
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cl02633
      Location:314 – 401
      Blast Score: 301
      ARID; ARID/BRIGHT DNA binding domain
      cl15261
      Location:575 – 630
      Blast Score: 171
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

    3. NM_023001.2 → NP_075377.2  AT-rich interactive domain-containing protein 4A isoform III

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks 207 bp in the coding region, as compared to variant 1, but maintains the same reading frame. The encoded protein lacks 69 internal codons and is thought to lack phosphorylation sites.
      Source sequence(s)
      AL139021, BC026230, BX279740, DB218466, S57162
      Consensus CDS
      CCDS9733.1
      UniProtKB/Swiss-Prot
      P29374
      UniProtKB/TrEMBL
      Q05CG0
      Related
      ENSP00000344556, ENST00000348476
      Conserved Domains (4) summary
      pfam08169
      Location:168 – 263
      Blast Score: 439
      RBB1NT; RBB1NT (NUC162) domain
      cl02573
      Location:58 – 113
      Blast Score: 116
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cl02633
      Location:314 – 401
      Blast Score: 300
      ARID; ARID/BRIGHT DNA binding domain
      cl15261
      Location:575 – 630
      Blast Score: 171
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      58765222..58840451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      38930721..39005059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL132989.5 (94327..144805) None
    genomic AL139021.6 (12768..36987) None
    genomic CH471061.1 EAW80727.1
      EAW80728.1
      EAW80729.1
      EAW80730.1
      EAW80731.1
      EAW80732.1
    mRNA AF086075.1 None
    mRNA AK307520.1 None
    mRNA AK307972.1 None
    mRNA BC026230.1 AAH26230.1
    mRNA BX279740.1 None
    mRNA DB218466.1 None
    mRNA S57153.1 AAB25833.1
    mRNA S57160.1 AAB25834.1
    mRNA S57162.1 AAB25835.2
    mRNA S66427.1 AAB28543.1
    other-genetic BC172363.1 AAI72363.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29374.3 GenPept UniProtKB/Swiss-Prot:P29374
    Q05CG0 GenPept UniProtKB/TrEMBL:Q05CG0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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