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    RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 [ Homo sapiens ]

    Gene ID: 5923, updated on 12-May-2012
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    Summary

    Official Symbol
    RASGRF1provided by HGNC
    Official Full Name
    Ras protein-specific guanine nucleotide-releasing factor 1provided by HGNC
    Primary source
    HGNC:9875
    See related
    Ensembl:ENSG00000058335; MIM:606600; Vega:OTTHUMG00000144172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1
    Summary
    The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
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    Genomic context

    Location :
    15q24.2
    Sequence :
    Chromosome: 15; NC_000015.9 (79252289..79383215, complement)
    See RASGRF1 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1 Neighboring gene cathepsin H Neighboring gene uncharacterized LOC100129540 Neighboring gene uncharacterized LOC729911 Neighboring gene microRNA 184 Neighboring gene heterogeneous nuclear ribonucleoprotein C (C1/C2) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Calvo F, et al. Nat Cell Biol, 2011 Jun 19. PMID 21685891.
    2. A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. Hysi PG, et al. Nat Genet, 2010 Oct. PMID 20835236.
    3. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. Marroni F, et al. Circ Cardiovasc Genet, 2009 Aug. PMID 20031603.
    4. Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. Calvo F, et al. Mol Biol Cell, 2009 Oct. PMID 19692568.
    5. The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue. Abreu JR, et al. Arthritis Res Ther, 2009. PMID 19678938.

    See all (38) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation.
      Title: RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.
    3. Single Nucleotide Polymorphisms in RASGRF1 is associated with refractive errors and myopia.
      Title: A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.
    4. Farnesylated or geranylgeranylated TC21 can be activated by RasGRF1 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes.
      Title: Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.
    5. Enhanced expression and post-translational modification of RasGRF1 contributes to MMP-3 production in RA
      Title: The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue.
    6. zoledronate induces DNA damage and S phase arrest, accompanied by activation of the ATM/Chk1/cdc25 pathway in a human osteosarcoma cell line
      Title: Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.
    7. RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex
      Title: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.
    8. Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes.
      Title: RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts.
    9. Vitamin K3 inhibitor H32 differentially inhibited growth of normal and liver tumor cells by preferentially inhibiting the actions of Cdc25 phosphatases
      Title: H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK.
    10. Rasgrf1 transgenic repeats serve at least two functions: first, to establish Rasgrf1 DNA methylation in the male germ line, and second, to resist global demethylation in the preimplantation embryo.
      Title: Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.

    A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13972 P04629 NTRK1    HPRD  PubMed  
    Q13972 Q16620 NTRK2    HPRD  PubMed  
    Q13972 Q16288 NTRK3    HPRD  PubMed  
    Q13972 P17612 PRKACA    HPRD  PubMed  
    Q13972 P63000 RAC1    HPRD  PubMed  
    Q13972 P61586 RHOA    HPRD  PubMed  
    Q13972 P62070 RRAS2    HPRD  PubMed  
    Q13972 Q07912 TNK2    HPRD  PubMed  
    Q13972 P40818 USP8    HPRD  PubMed  
    Q13972 P62258 YWHAE    HPRD  PubMed  
    BioGRID:111858 BioGRID:109501 HRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:111858 BioGRID:110310 MARK3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111858 BioGRID:124202 PPP1R9B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111858 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111858 BioGRID:113361 YWHAB    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
      Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
      Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
      Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
    • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RAC1 activity, organism-specific biosystem
      Regulation of RAC1 activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Serotonin Receptor 2 and ELK-SRF/GATA4 signaling, organism-specific biosystem (from WikiPathways)
      Serotonin Receptor 2 and ELK-SRF/GATA4 signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • TFs Regulate miRNAs related to cardiac hypertrophy, organism-specific biosystem (from WikiPathways)
      TFs Regulate miRNAs related to cardiac hypertrophy, organism-specific biosystemTranscription Factors that possibly regulate the expression of microRNAs related to cardiac hypertrophy. Interactions found by using TransMir. MicroRNAs are represented by a purple color and a rounde...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of Rac GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    long-term memory NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of Ras GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of Rac protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    synaptosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    ras-specific guanine nucleotide-releasing factor 1
    Names
    ras-specific guanine nucleotide-releasing factor 1
    guanine nucleotide exchange factor
    guanine nucleotide-releasing protein
    guanine nucleotide-releasing factor 1
    guanine nucleotide-releasing factor, 55 kD
    Ras-specific nucleotide exchange factor CDC25
    Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145648.1 → NP_001139120.1  ras-specific guanine nucleotide-releasing factor 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC011944, AK226101, AL355696, BC040275, DA126882
      Consensus CDS
      CCDS45320.1
      UniProtKB/TrEMBL
      F8VPA5
      UniProtKB/TrEMBL
      Q8IUU5
      Related
      ENSP00000452781, OTTHUMP00000248557, ENST00000558480, OTTHUMT00000418828
      Conserved Domains (5) summary
      cd00155
      Location:1018 – 1250
      Blast Score: 587
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00160
      Location:241 – 424
      Blast Score: 338
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd06224
      Location:639 – 689
      Blast Score: 131
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00821
      Location:25 – 127
      Blast Score: 147
      PH; Pleckstrin homology (PH) domain
      cl00273
      Location:478 – 583
      Blast Score: 88
      PH-like; Pleckstrin homology-like domain

    2. NM_002891.4 → NP_002882.3  ras-specific guanine nucleotide-releasing factor 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011944, AK226101, AK290135, AL355696, DA126882
      Consensus CDS
      CCDS10309.1
      UniProtKB/TrEMBL
      A8K270
      Related
      ENSP00000405963, OTTHUMP00000185565, ENST00000419573, OTTHUMT00000291371
      Conserved Domains (5) summary
      cd00155
      Location:1034 – 1266
      Blast Score: 588
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00160
      Location:241 – 424
      Blast Score: 338
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd06224
      Location:652 – 702
      Blast Score: 131
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00821
      Location:25 – 127
      Blast Score: 147
      PH; Pleckstrin homology (PH) domain
      cl00273
      Location:478 – 583
      Blast Score: 87
      PH-like; Pleckstrin homology-like domain

    3. NM_153815.2 → NP_722522.1  ras-specific guanine nucleotide-releasing factor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 5' exon, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a much shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC011944, AK226101, AL355696
      Consensus CDS
      CCDS42065.1
      UniProtKB/Swiss-Prot
      Q13972
      Related
      ENSP00000378228, OTTHUMP00000248558, ENST00000394745, OTTHUMT00000418829
      Conserved Domains (2) summary
      cd00155
      Location:250 – 482
      Blast Score: 589
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd06224
      Location:150 – 209
      Blast Score: 119
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      79252289..79383215, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      56012219..56142688, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011944.12 None
    genomic AC104231.10 (2070..66213) None
    genomic CH471136.2 EAW99141.1
      EAW99142.1
    mRNA AF370414.1 AAQ15250.1
    mRNA AK092325.1 None
    mRNA AK226101.1 None
    mRNA AK290135.1 BAF82824.1
    mRNA AK301205.1 BAH13432.1
    mRNA AK309047.1 None
    mRNA AL109674.1 None
    mRNA AL109675.1 None
    mRNA AL355696.1 None
    mRNA AL359931.1 None
    mRNA BC040275.1 AAH40275.1
    mRNA DA126882.1 None
    mRNA L26584.1 AAA58417.1
    mRNA M91815.1 None
    mRNA S62035.1 AAB26881.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13972.1 GenPept UniProtKB/Swiss-Prot:Q13972
    Q71RC4 GenPept UniProtKB/TrEMBL:Q71RC4
    Q8IUU5 GenPept UniProtKB/TrEMBL:Q8IUU5
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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