Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 [ Homo sapiens (human) ]

Gene ID: 5923, updated on 6-Jul-2014
Official Symbol
RASGRF1provided by HGNC
Official Full Name
Ras protein-specific guanine nucleotide-releasing factor 1provided by HGNC
Primary source
HGNC:9875
See related
Ensembl:ENSG00000058335; MIM:606600; Vega:OTTHUMG00000144172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1
Summary
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
See RASGRF1 in Epigenomics, MapViewer
Location:
15q24.2
Exon count :
30
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (78959947..79090873, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (79252289..79383215, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1 Neighboring gene cathepsin H Neighboring gene uncharacterized LOC729911 Neighboring gene microRNA 184 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
NHGRI GWA Catalog
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
NHGRI GWA Catalog
A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.
NHGRI GWA Catalog
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ras guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of Rac GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Ras GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of Rac protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
ras-specific guanine nucleotide-releasing factor 1
Names
ras-specific guanine nucleotide-releasing factor 1
guanine nucleotide exchange factor
guanine nucleotide-releasing protein
guanine nucleotide-releasing factor 1
guanine nucleotide-releasing factor, 55 kD
Ras-specific nucleotide exchange factor CDC25
Ras-specific guanine nucleotide-releasing factor, CDC25 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145648.1NP_001139120.1  ras-specific guanine nucleotide-releasing factor 1 isoform 3

    See proteins identical to NP_001139120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC011944, AK226101, AL355696, BC040275, DA126882
    Consensus CDS
    CCDS45320.1
    UniProtKB/TrEMBL
    Q8IUU5
    Related
    ENSP00000452781, OTTHUMP00000248557, ENST00000558480, OTTHUMT00000418828
    Conserved Domains (6) summary
    cd06224
    Location:639689
    Blast Score: 135
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00155
    Location:10181250
    Blast Score: 646
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:241424
    Blast Score: 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13261
    Location:19154
    Blast Score: 690
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    cl02520
    Location:922991
    Blast Score: 145
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431582
    Blast Score: 108
    PH-like; Pleckstrin homology-like domain
  2. NM_002891.4NP_002882.3  ras-specific guanine nucleotide-releasing factor 1 isoform 1

    See proteins identical to NP_002882.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011944, AK226101, AK290135, AL355696, DA126882
    Consensus CDS
    CCDS10309.1
    UniProtKB/TrEMBL
    A8K270
    UniProtKB/Swiss-Prot
    Q13972
    Related
    ENSP00000405963, OTTHUMP00000185565, ENST00000419573, OTTHUMT00000291371
    Conserved Domains (6) summary
    cd06224
    Location:652702
    Blast Score: 135
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00155
    Location:10341266
    Blast Score: 646
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:241424
    Blast Score: 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13261
    Location:19154
    Blast Score: 689
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    cl02520
    Location:9381007
    Blast Score: 145
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431582
    Blast Score: 108
    PH-like; Pleckstrin homology-like domain
  3. NM_153815.2NP_722522.1  ras-specific guanine nucleotide-releasing factor 1 isoform 2

    See proteins identical to NP_722522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 5' exon, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a much shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC011944, AK226101, AL355696
    Consensus CDS
    CCDS42065.1
    UniProtKB/Swiss-Prot
    Q13972
    Conserved Domains (2) summary
    cd00155
    Location:250482
    Blast Score: 652
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl02520
    Location:154223
    Blast Score: 147
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    78959947..79090873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720628.1XP_006720691.1  

    Conserved Domains (6) summary
    cd06224
    Location:639689
    Blast Score: 135
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00160
    Location:241424
    Blast Score: 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13261
    Location:19154
    Blast Score: 689
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00617
    Location:10221167
    Blast Score: 437
    RasGEF; RasGEF domain
    cl02520
    Location:922991
    Blast Score: 145
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431582
    Blast Score: 108
    PH-like; Pleckstrin homology-like domain
  2. XM_006720629.1XP_006720692.1  

    Conserved Domains (6) summary
    cd06224
    Location:652702
    Blast Score: 135
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00155
    Location:10311263
    Blast Score: 647
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:241424
    Blast Score: 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13261
    Location:19154
    Blast Score: 689
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    cl02520
    Location:9351004
    Blast Score: 145
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431582
    Blast Score: 109
    PH-like; Pleckstrin homology-like domain
  3. XM_005254578.2XP_005254635.1  

    Conserved Domains (6) summary
    cd06224
    Location:639689
    Blast Score: 138
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00160
    Location:241424
    Blast Score: 395
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13261
    Location:19154
    Blast Score: 689
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00617
    Location:10221178
    Blast Score: 443
    RasGEF; RasGEF domain
    cl02520
    Location:922991
    Blast Score: 147
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431582
    Blast Score: 111
    PH-like; Pleckstrin homology-like domain
  4. XM_006720627.1XP_006720690.1  

    Conserved Domains (6) summary
    cd06224
    Location:639689
    Blast Score: 137
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00160
    Location:241424
    Blast Score: 394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13261
    Location:19154
    Blast Score: 687
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00617
    Location:10221164
    Blast Score: 439
    RasGEF; RasGEF domain
    cl02520
    Location:922991
    Blast Score: 146
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431582
    Blast Score: 109
    PH-like; Pleckstrin homology-like domain

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    56012219..56142688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    79370538..79501430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...