RARS arginyl-tRNA synthetase [Homo sapiens] - Gene

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Summary

Official Symbol: RARSprovided by HGNC
Official Full Name: arginyl-tRNA synthetaseprovided by HGNC
Primary source: HGNC:9870
See related: Ensembl:ENSG00000113643; HPRD:00142; MIM:107820; Vega:OTTHUMG00000130411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ArgRS; DALRD1; MGC8641
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q35.1

Sequence :: Chromosome: 5; NC_000005.9 (167913463..167946311)

See RARS in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity
Title: Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
RARS over-expression impairs aminoacyl t-RNA synthetase interacting multifunctional protein (AIMP1) secretion by both HeLa and MCF7 cells.
Title: Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines.
leucyl-tRNA synthetase requires its C-terminal domain for its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex
Title: The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P54136	Q12904	AIMP1	HPRD	PubMed
P54136	P07814	EPRS	HPRD	PubMed
P54136	P47897	QARS	HPRD	PubMed
BioGRID:111852	BioGRID:114679	AIMP1	BioGRID	PubMed	Two-hybrid
BioGRID:111852	BioGRID:113684	AIMP2	BioGRID	PubMed	Two-hybrid
BioGRID:111852	BioGRID:108372	EPRS	BioGRID	PubMed	Two-hybrid
BioGRID:111852	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111852	BioGRID:111797	QARS	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:111852	BioGRID:116125	RNPS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111852	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111852	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
arginine binding	IEA Inferred from Electronic Annotation more info
arginine-tRNA ligase activity	TAS Traceable Author Statement more info
ligase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
arginyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
gene expression	TAS Traceable Author Statement more info
tRNA aminoacylation for protein translation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
aminoacyl-tRNA synthetase multienzyme complex	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
soluble fraction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: arginine--tRNA ligase, cytoplasmic

Names: arginine--tRNA ligase, cytoplasmic; arginine tRNA ligase 1, cytoplasmic; arginyl-tRNA synthetase, cytoplasmic

NP_002878.2

EC 6.1.1.19

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002887.3 → NP_002878.2 arginine--tRNA ligase, cytoplasmic

Status: REVIEWED

Source sequence(s)

AU125370, BM984528, BT007394, CA439316

Consensus CDS

CCDS4367.1

UniProtKB/Swiss-Prot

P54136

Related

ENSP00000231572, OTTHUMP00000160962, ENST00000231572, OTTHUMT00000252794

Conserved Domains (4) summary

PLN02286
Location:80 – 660
Blast Score: 1893

PLN02286; arginine-tRNA ligase

cd00671
Location:193 – 457
Blast Score: 671

ArgRS_core; catalytic core domain of arginyl-tRNA synthetases

cl04104
Location:78 – 166
Blast Score: 249

Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal domain

cl12020
Location:498 – 660
Blast Score: 334

Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

167913463..167946311

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

163012238..163045058

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC020894.5 (42391..75239)	None
genomic	CH471062.2	EAW61507.1
mRNA	AK222797.1	BAD96517.1
mRNA	AK302161.1	BAG63528.1
mRNA	AK314795.1	BAG37326.1
mRNA	AU125370.1	None
mRNA	BC000528.2	AAH00528.1
mRNA	BC014619.2	AAH14619.1
mRNA	BM984528.1	None
mRNA	BT007394.1	AAP36058.1
mRNA	CA439316.1	None
mRNA	S80343.1	AAB35627.1