Format

Send to:

Choose Destination

RAP2B RAP2B, member of RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5912, updated on 12-May-2016
Official Symbol
RAP2Bprovided by HGNC
Official Full Name
RAP2B, member of RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9862
See related
Ensembl:ENSG00000181467 HPRD:01548; MIM:179541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q25.2
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (153162212..153170624)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (152880001..152888413)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 13 Neighboring gene KIAA1328 pseudogene Neighboring gene uncharacterized LOC105374164 Neighboring gene uncharacterized LOC105374166 Neighboring gene uncharacterized LOC105374165

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC20484

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
ras-related protein Rap-2b
Names
small GTP binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002886.3NP_002877.2  ras-related protein Rap-2b

    See identical proteins and their annotated locations for NP_002877.2

    Status: REVIEWED

    Source sequence(s)
    AC117394, AI718675, AW997098, BC012362, BI551390, BQ378964, BU507815, BU860799, BX116683, BX355341, CB116910, HY071303
    Consensus CDS
    CCDS3170.1
    UniProtKB/Swiss-Prot
    P61225
    Related
    ENSP00000319096, OTTHUMP00000216113, ENST00000323534, OTTHUMT00000356707
    Conserved Domains (2) summary
    cd04176
    Location:3165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c
    pfam00071
    Location:16164
    Ras; Ras family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    153162212..153170624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    152843496..152851905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)