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Slc9a3r1 SLC9A3 regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59114, updated on 8-May-2016
Official Symbol
Slc9a3r1provided by RGD
Official Full Name
SLC9A3 regulator 1provided by RGD
Primary source
RGD:708538
See related
Ensembl:ENSRNOG00000003232
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
a membrane-cytoskeleton linking protein thought to be involved in sequestering and regulating the activity of integral membrane proteins, and in modulating membrane protein trafficking [RGD, Feb 2006]
Orthologs
Location:
10q32.2
Exon count:
6
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103713045..103730145)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (104573624..104590426, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693477 Neighboring gene RAB37, member RAS oncogene family Neighboring gene Cd300 molecule-like family member F Neighboring gene uncharacterized LOC103693478 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 Neighboring gene uncharacterized LOC102554289

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
beta-2 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
chloride channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
chloride channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IEA
Inferred from Electronic Annotation
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
auditory receptor cell stereocilium organization IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
 
bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
bile acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cellular phosphate ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
establishment of Golgi localization IEA
Inferred from Electronic Annotation
more info
 
establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
 
establishment of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
establishment of nucleus localization IEA
Inferred from Electronic Annotation
more info
 
establishment of nucleus localization ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
glutathione transport ISO
Inferred from Sequence Orthology
more info
 
glutathione transport ISS
Inferred from Sequence or Structural Similarity
more info
 
microvillus assembly IEA
Inferred from Electronic Annotation
more info
 
microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of catenin import into nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catenin import into nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
regulation of excretion IEA
Inferred from Electronic Annotation
more info
 
regulation of excretion ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
renal absorption ISO
Inferred from Sequence Orthology
more info
 
renal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
renal phosphate ion absorption ISO
Inferred from Sequence Orthology
more info
 
renal phosphate ion absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
renal sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
renal sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus ISO
Inferred from Sequence Orthology
more info
 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 
sperm midpiece ISO
Inferred from Sequence Orthology
more info
 
sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 
stereocilium ISO
Inferred from Sequence Orthology
more info
 
stereocilium tip IEA
Inferred from Electronic Annotation
more info
 
stereocilium tip ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Names
EBP50
ERM-binding phosphoprotein
NHERF-1
ezrin-radixin-moesin-binding phosphoprotein 50
regulatory cofactor of Na(+)/H(+) exchanger
sodium-hydrogen exchanger regulatory factor 1
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
solute carrier family 9 isoform A3 regulatory factor 1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021594.1NP_067605.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF1

    See identical proteins and their annotated locations for NP_067605.1

    Status: PROVISIONAL

    Source sequence(s)
    AF154336
    UniProtKB/Swiss-Prot
    Q9JJ19
    Related
    ENSRNOP00000004351, ENSRNOT00000004351
    Conserved Domains (2) summary
    cd00992
    Location:1291
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09007
    Location:318356
    EBP50_C-term; EBP50, C-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    103713045..103730145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    98979637..98995900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)