Format

Send to:

Choose Destination

RAP2A RAP2A, member of RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5911, updated on 12-May-2016
Official Symbol
RAP2Aprovided by HGNC
Official Full Name
RAP2A, member of RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9861
See related
Ensembl:ENSG00000125249 HPRD:01547; MIM:179540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KREV; RAP2; K-REV; RbBP-30
Orthologs
Location:
13q34
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (97434221..97467998)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (98086475..98120252)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene muscleblind like splicing regulator 2 Neighboring gene uncharacterized LOC101927385 Neighboring gene RNA, 5S ribosomal pseudogene 37 Neighboring gene proteasome subunit alpha 6 pseudogene 4 Neighboring gene uncharacterized LOC105370324 Neighboring gene uncharacterized LOC105370325

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

Go to the HIV-1, Human Interaction Database

  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
NOT establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
midbody IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ras-related protein Rap-2a
Names
RAP2, member of RAS oncogene family (K-rev)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021033.6NP_066361.1  ras-related protein Rap-2a precursor

    See identical proteins and their annotated locations for NP_066361.1

    Status: VALIDATED

    Source sequence(s)
    BC022356, BC041333, BC047495, CB215818, DA493957, DB480985
    Consensus CDS
    CCDS9485.1
    UniProtKB/Swiss-Prot
    P10114
    Related
    ENSP00000245304, OTTHUMP00000018581, ENST00000245304, OTTHUMT00000045528
    Conserved Domains (2) summary
    cd04176
    Location:3165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c
    pfam00071
    Location:16164
    Ras; Ras family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    97434221..97467998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    98056856..98090631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)