Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Ntrk1provided by RGD
Official Full Name: neurotrophic tyrosine kinase, receptor, type 1provided by RGD
Primary source: RGD:620144
See related: Ensembl:ENSRNOG00000013953
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Trk
Summary: a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006]

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Genomic context

Location :: 2q34

Sequence :: Chromosome: 2; NC_005101.2 (179838740..179855545, complement)

See Ntrk1 in MapViewer

Chromosome 2 - NC_005101.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NGF receptors are localized in the mitochondrial compartment of undifferentiated human podocytes and in all tissues analyzed including rat central nervous system.
Title: Localization of nerve growth factor (NGF) receptors in the mitochondrial compartment: characterization and putative role.
Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat.
Title: Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat.
We found remarkable changes of the behavior of TrkA upon the application of NGF
Title: Facilitated intracellular transport of TrkA by an interaction with nerve growth factor.
These results suggest that specific neurotrophins and trkA, B, and C receptors may contribute differentially to the survival and regenerative responses of extraocular motoneurons after lesion.
Title: Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion.
These studies identify a novel signaling circuit in which Trk activates ADAM17-dependent p75NTR production to feedback to sustain Trk signaling and Trk-dependent survival.
Title: Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.
Immobilised DHEA pulls down TrkA and p75NTR receptors, and induces TrkA- and p75NTR-mediated signaling. RNA interference against TrkA receptors reverses the anti-apoptotic effect of DHEA.
Title: Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.
TrkA trafficking and sorting are regulated by Nedd4-2 protein
Title: Regulation of trafficking of activated TrkA is critical for NGF-mediated functions.
there is a mechanistic link between Rab7 CMT2B mutants and altered TrkA and Erk1/2 signaling from endosomes
Title: Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.
These results indicate that the ubiquitin-proteasome system potentiates neurite formation by regulating the stability of TrkA receptors.
Title: Nerve growth factor-induced neurite outgrowth is potentiated by stabilization of TrkA receptors.
Data suggest that the effects of necdin deletion on the developing nervous system may depend on the relative expression of p75NTR and TrkA in the cells of particular regions of the nervous system.
Title: Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.

Submit: New GeneRIF Correction See all (86)

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_067600.1	NP_445793.1	Gipc1	BIND	PubMed	GIPC interacts with TRKA
NP_067600.1	NP_446462.1	Neu3	BIND	PubMed	Neu3 (PMGS) interacts with Ntrk1 (TrkA). This interaction was modeled on a demonstrated interaction between mouse PMGS and rat TrkA.
BioGRID:248731	BioGRID:251171	Ctsd	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:260280	Cyld	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:246737	Ngfr	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:253721	Psmb10	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:247611	Psmc2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:248093	Rab7a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:114397	SQSTM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:248731	BioGRID:250090	Shc1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:250206	Sqstm1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:259875	Traf6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:248372	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:248731	BioGRID:264439	Ube2l3	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor binding	ISO Inferred from Sequence Orthology more info
NOT nerve growth factor binding	ISO Inferred from Sequence Orthology more info
nerve growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
nerve growth factor receptor activity	ISO Inferred from Sequence Orthology more info
nerve growth factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
neurotrophin p75 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
B cell differentiation	IEA Inferred from Electronic Annotation more info
B cell differentiation	ISO Inferred from Sequence Orthology more info
Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
aging	IEP Inferred from Expression Pattern more info
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to nicotine	IDA Inferred from Direct Assay more info	PubMed
detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info
detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info
developmental programmed cell death	IDA Inferred from Direct Assay more info
learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
mechanoreceptor differentiation	ISO Inferred from Sequence Orthology more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
NOT negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of neuron apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of neuron apoptosis	ISO Inferred from Sequence Orthology more info
nerve growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
nerve growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
nervous system development	IEA Inferred from Electronic Annotation more info
nervous system development	ISO Inferred from Sequence Orthology more info
neuroprotection	IDA Inferred from Direct Assay more info
olfactory nerve development	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
NOT positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of Ras GTPase activity	ISO Inferred from Sequence Orthology more info
NOT positive regulation of Ras GTPase activity	ISO Inferred from Sequence Orthology more info
positive regulation of Ras GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
NOT positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
NOT positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of programmed cell death	IDA Inferred from Direct Assay more info
positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
response to activity	IDA Inferred from Direct Assay more info	PubMed
response to axon injury	IEP Inferred from Expression Pattern more info
response to drug	IDA Inferred from Direct Assay more info
response to electrical stimulus	IDA Inferred from Direct Assay more info	PubMed
response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
response to hydrostatic pressure	IEP Inferred from Expression Pattern more info	PubMed
response to nicotine	IDA Inferred from Direct Assay more info
response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
response to radiation	IEP Inferred from Expression Pattern more info
sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
Golgi membrane	TAS Traceable Author Statement more info
axon	IDA Inferred from Direct Assay more info	PubMed
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
dendrite	IDA Inferred from Direct Assay more info	PubMed
early endosome membrane	IEA Inferred from Electronic Annotation more info
endosome	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	ISO Inferred from Sequence Orthology more info
integral to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: high affinity nerve growth factor receptor

Names: high affinity nerve growth factor receptor; trk; trk-A; p140-TrkA; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A; slow nerve growth factor receptor

NP_067600.1

EC 2.7.10.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021589.1 → NP_067600.1 high affinity nerve growth factor receptor precursor

Status: PROVISIONAL

Source sequence(s)

M85214

UniProtKB/Swiss-Prot

P35739

Related

ENSRNOP00000018961, ENSRNOT00000018961

Conserved Domains (6) summary

cd04971
Location:301 – 382
Blast Score: 356

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:197 – 284
Blast Score: 206

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:507 – 786
Blast Score: 1430

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

pfam07679
Location:196 – 284
Blast Score: 97

I-set; Immunoglobulin I-set domain

smart00082
Location:148 – 166
Blast Score: 84

LRRCT; Leucine rich repeat C-terminal domain

pfam07714
Location:513 – 784
Blast Score: 977

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005101.2 Reference assembly (based on RGSC_v3.4)

Range

179838740..179855545, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000070.1 Alternate assembly (Rn_Celera)

Range

167186754..167203558, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473976.2	EDM00771.1
		EDM00772.1
genomic	L13769.1	None
mRNA	AF174586.1	AAF77635.1	W
mRNA	AF174587.1	AAF77636.1	W
mRNA	M85214.1	AAA42286.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P35739.1	GenPept	UniProtKB/Swiss-Prot:P35739
Q9JIW6	GenPept	UniProtKB/TrEMBL:Q9JIW6
Q9JIW7	GenPept	UniProtKB/TrEMBL:Q9JIW7