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    RAP1A RAP1A, member of RAS oncogene family [ Homo sapiens ]

    Gene ID: 5906, updated on 19-May-2012
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    Summary

    Official Symbol
    RAP1Aprovided by HGNC
    Official Full Name
    RAP1A, member of RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:9855
    See related
    Ensembl:ENSG00000116473; HPRD:01545; MIM:179520; Vega:OTTHUMG00000011959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAP1; KREV1; KREV-1; SMGP21
    Summary
    The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

    Location :
    1p13.3
    Sequence :
    Chromosome: 1; NC_000001.10 (112233954..112256101)
    See RAP1A in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129269 Neighboring gene keratin 18 pseudogene Neighboring gene family with sequence similarity 212, member B Neighboring gene uncharacterized LOC100506343 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Consonni SV, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22343288.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1. Dash-Koney M, et al. J Leukoc Biol, 2011 Oct. PMID 21750123.
    4. Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. Mor A, et al. J Invest Dermatol, 2011 Oct. PMID 21716322.
    5. Ser756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2. Lim J, et al. Biochem J, 2011 Aug 1. PMID 21605078.

    See all (139) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. cAMP induces a conformational change in Epac1 that enables DEP domain-mediated binding to phosphatidic acid, resulting in the tethering of Epac1 at the plasma membrane and subsequent activation of Rap
      Title: cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane.
    2. farnesylthiosalicylic acid-amide inhibits contact sensitivity through Rap1 inhibition
      Title: Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor.
    3. Epac1 is expressed in human neutrophils and is involved in cAMP-dependent regulation of Rap1. However, the loading of GTP on Rap1 per se is not sufficient to promote activation of beta2 integrins.
      Title: Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1.
    4. These results demonstrate a distinct physiological role for Ser(756) of beta2 integrin, in conjunction with the actions of talin and Rap1, during alphaMbeta2 activation in macrophages.
      Title: Ser756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2.
    5. For the first time, a role has been shown for Rap1-mediated association between adherens junction and tight junction complexes in the 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-induced pulmonary vascular endothelial cell barrier protection.
      Title: Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids.
    6. Rap1A binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A
      Title: The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.
    7. cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity
      Title: The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.
    8. PA and Rap1 cooperatively regulate RA-RhoGAP activity for promoting neurite outgrowth.
      Title: Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.
    9. Results indicate that guanine nucleotide exchange and interactions with SmgGDS splice variants can regulate the entrance and passage of PBR-possessing small GTPases through the prenylation pathway.
      Title: Splice variants of SmgGDS control small GTPase prenylation and membrane localization.
    10. Rap1-mediated activation of alpha(M)beta(2) in macrophages shares both common and distinct features from Rap1 activation of alpha(IIb)beta(3) expressed in CHO cells.
      Title: Rap1 controls activation of the α(M)β(2) integrin in a talin-dependent manner.
    Submit: New GeneRIF Correction See all (73)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001010935.1 NP_006257.1 RALGDS    BIND  PubMed Rap1A interacts with RalGDS. This interaction was modeled on a demonstrated interaction between human Rap1A and RalGDS from an unspecified species. 
    NP_001010935.1 RAPGEF1    BIND  PubMed Rap1A interacts with an unspecified isoform of C3G. 
    NP_001010935.1 NP_006096.2 RAPGEF3    BIND  PubMed Rap1A interacts with Epac1. 
    NP_001010935.1 NP_008954.1 RAPGEF4    BIND  PubMed Rap1A interacts with Epac2. This interaction was modeled on a demonstrated interaction between human Rap1A and mouse Epac2. 
    NP_001010935.1 Q92565 RAPGEF5    BIND  PubMed Rap1A interacts with Repac. 
    NP_002875.1 NP_061916.3 APBB1IP    BIND  PubMed RIAM interacts with Rap1. 
    P62834 Q7Z5R6 APBB1IP    HPRD  PubMed  
    P62834 O00499 BIN1    HPRD  PubMed  
    P62834 P51813 BMX    HPRD  PubMed  
    P62834 P15056 BRAF    HPRD  PubMed  
    P62834 Q13158 FADD    HPRD  PubMed  
    P62834 Q9UNN5 FAF1    HPRD  PubMed  
    P62834 P25445 FAS    HPRD  PubMed  
    P62834 Q13547 HDAC1    HPRD  PubMed  
    P62834 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P62834 O00522 KRIT1    HPRD  PubMed  
    P62834 P55196 MLLT4    HPRD  PubMed  
    P62834 P48039 MTNR1A    HPRD  PubMed  
    P62834 P04629 NTRK1    HPRD  PubMed  
    P62834 O43924 PDE6D    HPRD  PubMed  
    P62834 P30153 PPP2R1A    HPRD  PubMed  
    P62834 P17612 PRKACA    HPRD  PubMed  
    P62834 Q9UI14 RABAC1    HPRD  PubMed  
    P62834 P04049 RAF1    HPRD  PubMed  
    P62834 Q12967 RALGDS    HPRD  PubMed  
    P62834 P62834 RAP1A    HPRD  PubMed  
    P62834 P52306 RAP1GDS1    HPRD  PubMed  
    P62834 Rap guanine nucleotide exchange factor (GEF) 2 RAPGEF2    HPRD  PubMed  
    P62834 Q92565 RAPGEF5    HPRD  PubMed  
    P62834 Q8TEU7 RAPGEF6    HPRD  PubMed  
    P62834 P20936 RASA1    HPRD  PubMed  
    P62834 Q14644 RASA3    HPRD  PubMed  
    P62834 RAS guanyl nucleotide releasing protein 2 RASGRP2    HPRD  PubMed  
    P62834 RASGRP4 RASGRP4    HPRD  PubMed  
    P62834 Q5U651 RASIP1    HPRD  PubMed  
    P62834 Ral GDS related protein Rgr RGL4    HPRD  PubMed  
    P62834 O43566 RGS14    HPRD  PubMed  
    P62834 P51532 SMARCA4    HPRD  PubMed  
    P62834 Q14241 TCEB3    HPRD  PubMed  
    P62834 O14798 TNFRSF10C    HPRD  PubMed  
    BioGRID:111841 BioGRID:114585 ARHGEF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:107141 BRAF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111841 BioGRID:116473 GABARAPL2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:107330 KRIT1    BioGRID  PubMed Two-hybrid 
    BioGRID:111841 BioGRID:110447 MLLT4    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111841 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111841 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111841 BioGRID:111173 PDE6D    BioGRID  PubMed Two-hybrid 
    BioGRID:111841 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111841 BioGRID:111831 RAF1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:111841 BioGRID:111834 RALA    BioGRID  PubMed Two-hybrid 
    BioGRID:111841 BioGRID:111836 RALGDS    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111841 BioGRID:111844 RAP1GAP    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:111845 RAP1GDS1    BioGRID  PubMed Two-hybrid 
    BioGRID:111841 BioGRID:115045 RAPGEF2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:111841 BioGRID:115682 RAPGEF3    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:116253 RAPGEF4    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:115116 RAPGEF5    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:119705 RAPGEF6    BioGRID  PubMed Biochemical Activity 
    BioGRID:111841 BioGRID:129336 RGL4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111841 BioGRID:115880 RGS14    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111841 BioGRID:111941 RHEB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111841 BioGRID:116106 RUNDC3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111841 BioGRID:113100 TSC2    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:111841 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
      ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events, organism-specific biosystem
      Class I PI3K signaling events
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Frs2-mediated activation, organism-specific biosystem (from REACTOME)
      Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
    • GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem (from REACTOME)
      GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting Grb2 to the FADK1/SRC activation complex.
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
    • Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
      Integrin alphaIIb beta3 signaling, organism-specific biosystemAt the sites of vascular injury bioactive molecules such as thrombin, ADP, collagen, fibrinogen and thrombospondin are generated, secreted or exposed. These stimuli activate platelets, converting the...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
      Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
      Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
    • Rap1 signalling, organism-specific biosystem (from REACTOME)
      Rap1 signalling, organism-specific biosystemRap1 (Ras-proximate-1) is a small G protein in the Ras superfamily. Like all G proteins, Rap1 is activated when bound GDP is exchanged for GTP. Rap1 is targeted to lipid membranes by the covalent att...
    • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Reelin signaling pathway, organism-specific biosystem
      Reelin signaling pathway
    • Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
      Regulation of Insulin Secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...
    • Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystem (from REACTOME)
      Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystemGlucagon-like Peptide-1 (GLP-1) is secreted by L-cells in the intestine in response to glucose and fatty acids. GLP-1 circulates to the beta cells of the pancreas where it binds a G-protein coupled r...
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystem (from WikiPathways)
      Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem
      Signaling events regulated by Ret tyrosine kinase
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
      p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Ras GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    GTP catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    activation of MAPKK activity TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    energy reserve metabolic process TAS
    Traceable Author Statement
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    regulation of insulin secretion TAS
    Traceable Author Statement
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    guanyl-nucleotide exchange factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    ras-related protein Rap-1A
    Names
    ras-related protein Rap-1A
    C21KG
    G-22K
    RAS-related protein RAP1A
    Ras-related protein Krev-1
    GTP-binding protein smg p21A
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010935.1 → NP_001010935.1  ras-related protein Rap-1A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC014086, BI460853, BU150941
      Consensus CDS
      CCDS840.1
      UniProtKB/TrEMBL
      A8KAH9
      UniProtKB/Swiss-Prot
      P62834
      Conserved Domains (1) summary
      cd04175
      Location:18 – 167
      Blast Score: 773
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    2. NM_002884.2 → NP_002875.1  ras-related protein Rap-1A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC014086, BI460853, BU150941
      Consensus CDS
      CCDS840.1
      UniProtKB/TrEMBL
      A8KAH9
      UniProtKB/Swiss-Prot
      P62834
      Related
      ENSP00000394318, ENST00000436150
      Conserved Domains (1) summary
      cd04175
      Location:18 – 167
      Blast Score: 773
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      112233954..112256101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      110105309..110127466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic A08691.1 CAA00804.1
    genomic AL049557.19 CAB55685.2
      CAI22712.1
    genomic AL139012.14 (12773..41550) None
    genomic CH471122.1 EAW56503.1
    mRNA AB051846.1 BAB61868.1
    mRNA AB451235.1 BAG70049.1
    mRNA AB451360.1 BAG70174.1
    mRNA AF493912.1 AAM12626.1
    mRNA AK293044.1 BAF85733.1
    mRNA BC014086.2 AAH14086.1
    mRNA BI460853.1 None
    mRNA BT019666.1 AAV38472.1
    mRNA BU150941.1 None
    mRNA M22995.1 AAA36150.1
    mRNA X12533.1 CAA31051.1
    other-genetic EU831467.1 ACE87154.1
    other-genetic EU831554.1 ACE86473.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62834.1 GenPept UniProtKB/Swiss-Prot:P62834
    Q5U0C3 GenPept UniProtKB/TrEMBL:Q5U0C3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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