RALA v-ral simian leukemia viral oncogene homolog A (ras related) [Homo sapiens] - Gene

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Summary

Official Symbol: RALAprovided by HGNC
Official Full Name: v-ral simian leukemia viral oncogene homolog A (ras related)provided by HGNC
Primary source: HGNC:9839
See related: Ensembl:ENSG00000006451; HPRD:01549; MIM:179550; Vega:OTTHUMG00000128775
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAL; MGC48949
Summary: The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 7p15-p13

Sequence :: Chromosome: 7; NC_000007.13 (39663152..39747723)

See RALA in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that disrupting either RALA or RALBP1 leads to a loss of mitochondrial fission at mitosis, improper segregation of mitochondria during cytokinesis and a decrease in ATP levels and cell number.
Title: RALA and RALBP1 regulate mitochondrial fission at mitosis.
Our results identify a role for RalA and RalB in cell-mediated cytotoxicity
Title: Ral GTPases regulate cell-mediated cytotoxicity in NK cells.
conclude that the ability of hRgr to activate both Ral and Ras is responsible for its transformation-inducing phenotype and it could be an important contributor in the development of some T-cell malignancies
Title: The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral.
The RalA was not only cytoprotective against multiple chemotherapeutic drugs, but also promigratory inducing stress fiber formation, which was accompanied by the activation of Akt and Erk pathways.
Title: Comparative analysis of the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA.
RalA, the binding partner of PKC eta, is involved in not only the keratinocyte differentiation induced by PKCeta overexpression but also in normal keratinocyte differentiation induced by calcium and cholesterol sulfate.
Title: Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation.
Correlation between RalA protein expression decrease and absence of regional metastases was revealed for squamous cell lung cancer.
Title: [Arf6, RalA and BIRC5 protein expression in non small cell lung cancer].
Ral is a critical regulator in PMN that specifically controls secondary granule release during PMN response to chemoattractant stimulation.
Title: Control of secondary granule release in neutrophils by Ral GTPase.
studies suggest that the expression of RalBP1 is necessary for human cancer cell metastasis; show that the requirement for RalA expression for manifestation of this phenotype is not entirely dependent on a RalA-RalBP1 interaction
Title: RalBP1 is necessary for metastasis of human cancer cell lines.
RalA interaction with the Exo84 but not Sec5 exocyst component was necessary for supporting anchorage-independent growth, whereas RalB interaction with Sec5 but not Exo84 was necessary for inhibition of anchorage-independent growth
Title: Activation and involvement of Ral GTPases in colorectal cancer.
RalA is activated by Salmonella infection in a SopE-dependent manner, and is required for exocyst assembly.
Title: Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex.

Submit: New GeneRIF Correction See all (33)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005393.2	NP_003642.2	CSDA	BIND	PubMed	RalA interacts with ZONAB. This interaction was modeled on a demonstrated interaction between human or canine RalA and canine ZONAB.
NP_005393.2	NP_060773.3	EXOC2	BIND	PubMed	RalA interacts with Sec5. This interaction was modelled on a demonstrated interaction between human RalA and Sec5 from an unspecified species.
NP_005393.2	NP_006779.1	RALBP1	BIND	PubMed	RalA interacts with RalBP1.
NP_005393.2	NP_006779.1	RALBP1	BIND	PubMed	RalA interacts with RLIP76.
P11233	P84077	ARF1	HPRD	PubMed
P11233	Calmodulin 1	CALM1	HPRD	PubMed
P11233	Q8WXI2	CNKSR2	HPRD	PubMed
P11233	P16989	CSDA	HPRD	PubMed
P11233	Q9NV70	EXOC1	HPRD	PubMed
P11233	Q96KP1	EXOC2	HPRD	PubMed
P11233	O60645	EXOC3	HPRD	PubMed
P11233	Q96A65	EXOC4	HPRD	PubMed
P11233	O00471	EXOC5	HPRD	PubMed
P11233	Exocyst complex component 6B	EXOC6B	HPRD	PubMed
P11233	Q9UPT5	EXOC7	HPRD	PubMed
P11233	Q8IYI6	EXOC8	HPRD	PubMed
P11233	P21333	FLNA	HPRD	PubMed
P11233	P51178	PLCD1	HPRD	PubMed
P11233	Q13393	PLD1	HPRD	PubMed
P11233	P30154	PPP2R1B	HPRD	PubMed
P11233	Q92930	RAB8B	HPRD	PubMed
P11233	Q15311	RALBP1	HPRD	PubMed
P11233	RALGEF2	RALGPS1	HPRD	PubMed
P11233	Q8WWW0	RASSF5	HPRD	PubMed
P11233	Q96D71	REPS1	HPRD	PubMed
P11233	Ral GDS related protein Rgr	RGL4	HPRD	PubMed
P11233	Q13485	SMAD4	HPRD	PubMed
BioGRID:111834	BioGRID:106870	ARF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111834	BioGRID:106877	ARF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111834	BioGRID:107252	CALM1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:111834	BioGRID:544691	CALM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111834	BioGRID:116534	CNKSR2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111834	BioGRID:120887	EXOC2	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:111834	BioGRID:127206	EXOC8	BioGRID	PubMed	Two-hybrid
BioGRID:111834	BioGRID:251644	Exoc3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111834	BioGRID:250539	Exoc4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111834	BioGRID:108605	FLNA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111834	BioGRID:109501	HRAS	BioGRID	PubMed	Two-hybrid
BioGRID:111834	BioGRID:110221	LRPAP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111834	BioGRID:111349	PLCD1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:111834	BioGRID:111353	PLD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111834	BioGRID:111507	PPP2CA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111834	BioGRID:111511	PPP2R1B	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111834	BioGRID:116131	RALBP1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:111834	BioGRID:115007	RALGPS1	BioGRID	PubMed	Biochemical Activity
BioGRID:111834	BioGRID:111841	RAP1A	BioGRID	PubMed	Two-hybrid
BioGRID:111834	BioGRID:111846	RAP2A	BioGRID	PubMed	Two-hybrid
BioGRID:111834	BioGRID:111847	RAP2B	BioGRID	PubMed	Two-hybrid
BioGRID:111834	BioGRID:111801	RGL2	BioGRID	PubMed	Two-hybrid
BioGRID:111834	BioGRID:129336	RGL4	BioGRID	PubMed	Reconstituted Complex
BioGRID:111834	BioGRID:249880	Ralbp1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111834	BioGRID:113100	TSC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111834	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
Edg-2 lysophosphatidic acid receptor binding	IDA Inferred from Direct Assay more info	PubMed
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Ras protein signal transduction	TAS Traceable Author Statement more info
actin cytoskeleton reorganization	IDA Inferred from Direct Assay more info	PubMed
cell cycle	IEA Inferred from Electronic Annotation more info
chemotaxis	TAS Traceable Author Statement more info	PubMed
cytokinesis	IDA Inferred from Direct Assay more info	PubMed
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
membrane raft localization	IDA Inferred from Direct Assay more info
nerve growth factor receptor signaling pathway	TAS Traceable Author Statement more info
positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
regulation of exocytosis	IDA Inferred from Direct Assay more info
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
midbody	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: ras-related protein Ral-A

Names: ras-related protein Ral-A; RAS-like protein A; Ras family small GTP binding protein RALA

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005402.3 → NP_005393.2 ras-related protein Ral-A precursor

Status: REVIEWED

Source sequence(s)

BC039858, BM930625, DC313757

Consensus CDS

CCDS5460.1

UniProtKB/Swiss-Prot

P11233

Related

ENSP00000005257, OTTHUMP00000158977, ENST00000005257, OTTHUMT00000250696

Conserved Domains (1) summary

cd04139
Location:15 – 177
Blast Score: 775

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

39663152..39747723

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

39547203..39631708

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

39701014..39785596

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004837.1 (35256..119813)	None
genomic	CH236951.1	EAL23994.1
genomic	CH471073.1	EAW94122.1
		EAW94123.1
mRNA	AF086082.1	None
mRNA	AF493910.1	AAM12624.1
mRNA	AK026850.1	None
mRNA	AK308109.1	None
mRNA	AU132355.1	None
mRNA	BC039858.1	AAH39858.1
mRNA	BM930625.1	None
mRNA	DC313757.1	None
mRNA	M29893.1	AAA36542.1
mRNA	X15014.1	CAA33118.1