Gas6 growth arrest specific 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58935, updated on 11-Apr-2024

Summary

Official Symbol: Gas6provided by RGD
Official Full Name: growth arrest specific 6provided by RGD
Primary source: RGD:61913
See related: Ensembl:ENSRNOG00000018233 AllianceGenome:RGD:61913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including activation of protein kinase B activity; positive regulation of intracellular signal transduction; and regulation of renal system process. Located in extracellular space. Used to study glomerulonephritis. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 929.4), Heart (RPKM 800.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82747676..82778090)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76045430..76075904)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81213364..81243824, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway.
Title: Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway.
Celastrol mitigates high glucose-induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR-345-5p/growth arrest-specific 6.
Title: Celastrol mitigates high glucose-induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR-345-5p/growth arrest-specific 6.
recombinant Gas6 reduced the neurological deficits by inhibiting neuroinflammation via the TLR/TRAF/NF-kappaB signaling pathway after middle cerebral artery occlusion (MCAO) in rats
Title: Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after MCAO in rats.
Growth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action
Title: Growth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action.
the Gas6/Axl interaction was inhibited by R428, which abolished the preventive effect of VK2 on CaCl2- and beta-GP-induced apoptosis and calcification. These results suggest that Gas6 is critical in VK2-mediated functions that attenuate CaCl2- and beta-GP-induced VSMC calcification by blocking apoptosis.
Title: Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
GAS6 has a role in the regulation of pancreatic beta cells in the critical period around the time of birth
Title: Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.
Glucose alters Axl signaling through coupling to binding partners and suggests a mechanism by which Axl contributes to vascular smooth muscle cells dysfunction in diabetes.
Title: Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells.
expression of gamma-carboxylated Gas6 was strongly induced in HSC along with their transformation into myofibroblasts, and it exerted an anti-apoptotic effect on both HSC and HSC/MFB mediated by the Axl/PI3-kinase/Akt pathway.
Title: Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells.
Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy
Title: Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy.
The ability of Gas6 to prevent apoptosis requires both Gas6 binding to Axl and Axl kinase activity.
Title: Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in B cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in B cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vitamin K	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vitamin K	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix assembly	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in fusion of virus membrane with host plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell migration to bone marrow	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell migration to bone marrow	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biomineral tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of renal albumin absorption	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glomerular filtration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated virion attachment to host cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue regeneration	TAS Traceable Author Statement more info	PubMed
involved_in tissue remodeling	TAS Traceable Author Statement more info	PubMed
involved_in viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in viral genome replication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth arrest-specific protein 6

Names: AXL receptor tyrosine kinase ligand; GAS-6; GPF; growth-potentiating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057100.2 → NP_476441.2 growth arrest-specific protein 6 precursor

See identical proteins and their annotated locations for NP_476441.2

Status: PROVISIONAL

Source sequence(s)

BC070881

UniProtKB/Swiss-Prot

Q63772

UniProtKB/TrEMBL

A6IWG8, Q6IRL1

Related

ENSRNOP00000024677.4, ENSRNOT00000024677.7

Conserved Domains (7) summary

smart00069
Location:26 → 90

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

smart00179
Location:194 → 225

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:115 → 150

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:295 → 447

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:510 → 647

Laminin_G_2; Laminin G domain

pfam12662
Location:215 → 238

cEGF; Complement Clr-like EGF-like

pfam14670
Location:157 → 192

FXa_inhibition; Coagulation Factor Xa inhibitory site