MOK MOK protein kinase [Homo sapiens] - Gene

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Summary

Official Symbol: MOKprovided by HGNC
Official Full Name: MOK protein kinaseprovided by HGNC
Primary source: HGNC:9833
See related: Ensembl:ENSG00000080823; HPRD:09310; MIM:605762; Vega:OTTHUMG00000164896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAGE; RAGE1; RAGE-1

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Genomic context

Location :: 14q32

Sequence :: Chromosome: 14; NC_000014.8 (102695178..102771531, complement)

See MOK in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups.
Title: TLR4 and RAGE: similar routes leading to inflammation in type 2 diabetic patients.
The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B.
Title: S100B attenuates microglia activation in gliomas: possible role of STAT3 pathway.
POLL is under genetic selection in Sub-Saharan African populations.
Title: Targeted resequencing of two genes, RAGE and POLL, confirms findings from a genome-wide scan for adaptive evolution and provides evidence for positive selection in additional populations.
Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma.
Title: The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker.
RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components
Title: Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas.
May provide suitable targets for immunotherapy of renal cell carcinoma.
Title: Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma.
identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2
Title: Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9UQ07	P14635	CCNB1	HPRD	PubMed
Q9UQ07	P05412	JUN	HPRD	PubMed
Q9UQ07	P01106	MYC	HPRD	PubMed
BioGRID:111828	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	TAS Traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: MAPK/MAK/MRK overlapping kinase

Names: MAPK/MAK/MRK overlapping kinase; renal tumor antigen 1; renal cell carcinoma antigen (MOK protein kinase)

NP_055041.1

EC 2.7.11.22

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014226.1 → NP_055041.1 MAPK/MAK/MRK overlapping kinase

Status: PROVISIONAL

Source sequence(s)

AB022694

Consensus CDS

CCDS9971.1

UniProtKB/Swiss-Prot

Q9UQ07

Related

ENSP00000355304, OTTHUMP00000227854, ENST00000361847, OTTHUMT00000380848

Conserved Domains (2) summary

cd07831
Location:4 – 285
Blast Score: 1482

STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

smart00220
Location:4 – 285
Blast Score: 643

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

102695178..102771531, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

82874021..82948654, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL352978.6 (37780..107797)	None
genomic	AL359402.3 (110955..117290)	None
genomic	CH471061.1	EAW81772.1
		EAW81773.1
		EAW81774.1
		EAW81775.1
		EAW81776.1
		EAW81777.1
		EAW81778.1
		EAW81779.1
		EAW81780.1
genomic	HH961882.1	CBX51414.1
mRNA	AB022694.1	BAA81688.1
mRNA	AK094003.1	None
mRNA	AK094747.1	None
mRNA	AK302349.1	BAH13682.1
mRNA	AK312778.1	BAG35641.1
mRNA	BC026069.1	AAH26069.1
mRNA	BC043179.1	AAH43179.1
mRNA	BC053536.1	AAH53536.1
mRNA	U46191.1	AAB38077.1
		AAB38079.1
mRNA	U46192.1	AAB38080.1
		AAB38081.1
		AAB38082.1
mRNA	U46193.1	AAB38083.1
		AAB38084.1
		AAB38085.1
mRNA	U46194.1	AAB38087.1