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    RAD51 RAD51 homolog (S. cerevisiae) [ Homo sapiens (human) ]

    Gene ID: 5888, updated on 18-May-2013
    Official Symbol
    RAD51provided by HGNC
    Official Full Name
    RAD51 homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:9817
    See related
    Ensembl:ENSG00000051180; HPRD:01557; MIM:179617; Vega:OTTHUMG00000130067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
    Summary
    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Location :
    15q15.1
    Sequence :
    Chromosome: 15; NC_000015.9 (40987327..41024356)
    See RAD51 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene cancer susceptibility candidate 5 Neighboring gene uncharacterized LOC100505648 Neighboring gene regulator of microtubule dynamics 3 Neighboring gene GTP cyclohydrolase I feedback regulator

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. Courilleau C, et al. J Cell Biol, 2012 Dec 24. PMID 23266955.
    2. RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland. Romanowicz-Makowska H, et al. Pol J Pathol, 2012 Nov. PMID 23161237.
    3. Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Chun J, et al. Mol Cell Biol, 2013 Jan. PMID 23149936.
    4. A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women. Romanowicz-Makowska H, et al. Eur J Gynaecol Oncol, 2012. PMID 23091899.
    5. RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. Tennstedt P, et al. Int J Cancer, 2013 May 1. PMID 23065657.

    See all (403) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. RAD51 overexpression is associated with colorectal adenocarcinoma.
      Title: RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma.
    2. Our results suggest that variant genotypes of the 135G>C of RAD51 polymorphism may be positively associated with colorectal carcinoma in the Polish population
      Title: RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland.
    3. The results of this study suggest that SAHA, a recently approved HDI in clinical trials for malignancies, at lower concentrations may act as a radiosensitizer via disruption of the RAD51-dependent HDR pathway.
      Title: Suberoylanilide hydroxamic acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed repair in multiple myeloma.
    4. p400 and Rad51 are present in the same complex and both favor chromatin remodeling around DNA double strand breaks.
      Title: The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.
    5. Human Rad51 paralogs facilitate BRCA2-Rad51-dependent homologous recombination at different stages in the pathway and function independently of Rad52.
      Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
    6. Our study reveal no significance association of 135 G/C RAD51 polymorphism with occurrence and progression of colorectal cancer.
      Title: Lack of association between the 135G/C RAD51 gene polymorphism and the risk of colorectal cancer among Polish population.
    7. DNA damage repair is mediated by the binding of HSF4 to a heat shock element in the Rad51 promoter, a gene which assists in the homologous recombination (HR) repair of DNA strand breaks.
      Title: HSF4 is involved in DNA damage repair through regulation of Rad51.
    8. Data indicate that RNF8-dependent chromatin ubiquitination is required for RAD51 assembly in BRCA1/53BP1-depleted cells.
      Title: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.
    9. study found low levels of mutant RAD51 protein were sufficient for disruption of RAD51 activity and generation of chromosomal rearrangements.
      Title: RAD51 mutants cause replication defects and chromosomal instability.
    10. the polymorphism 135G > C of RAD51 may be positively associated with ovarian carcinoma in the Polish population.
      Title: A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women.
    Submit: New GeneRIF Correction See all (225)

    Review eQTL and phenotype association data in this region using PheGenI

    Familial cancer of breast

    Summary from GeneReviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer Go to GeneReviews

    Disease Characteristics
    A germline mutation in BRCA1 or BRCA2 predisposes to breast and ovarian cancer as well as other cancers. The risk of developing cancer that is associated with a germline BRCA1 or BRCA2 mutation, which has been derived from families with multiple affected individuals, families with few affected individuals, and from population-based studies, appears to be variable within families. Prognosis for breast and ovarian cancer depends on the stage at which the cancer is diagnosed; however, studies on survival have revealed conflicting results for individuals with germline BRCA1 or BRCA2 mutations when compared to controls.
    Diagnosis Testing
    Molecular genetic testing for germline BRCA1 and BRCA2 mutations is available on a clinical basis for individuals who are identified to be at high risk based on their personal and/or family history and for at-risk relatives of an individual with an identified germline BRCA1 or BRCA2 mutation. No currently available technique can guarantee the identification of all cancer-predisposing mutations in BRCA1 or BRCA2. Furthermore, mutations of uncertain clinical significance may be identified.
    Genetic Counseling
    Germline mutations in BRCA1 and BRCA2 are inherited in an autosomal dominant manner. Each offspring of an individual with a BRCA1 or BRCA2 germline mutation has a 50% chance of inheriting the mutation. Molecular genetic testing of asymptomatic family members at risk of inheriting either a BRCA1 or BRCA2 germline mutation is feasible once the family-specific mutation has been identified. Prenatal testing is possible for pregnancies at increased risk if the cancer-predisposing mutation in the family is known; however, requests for prenatal diagnosis of adult-onset diseases are uncommon and require careful genetic counseling.
    References
    Protein Gene Interaction Pubs
    Tat, p14 tat Expression of Rad51 enhances basal- and HIV-1 Tat-induced transcription of the HIV-1 LTR promoter; this event requires cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP) PubMed
    tat In PC12 cells treated with genotoxic agents, HIV-1 Tat reduces DNA breakage and increases repair of DNA double-strand breaks through a mechanism involving the upregulation of Rad51, a key regulator of homologous recombination in cells PubMed
    tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes HRAD51, during Tat-mediated transactivation of the HIV-1 LTR PubMed
    Vpr, p15 vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr HIV-1 Vpr stimulates the focus formation of Rad51 and BRCA1, which are involved in repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) PubMed
    pol gag-pol K133A RAD51 mutant remains to bind DNA but is unable to form an active nucleofilament due to the poor binding of ATP, which results in the defect on IN inhibition PubMed
    gag-pol RAD51 protein inhibits the integration catalyzed by HIV-1 integrase both in vitro, in yeast expressing integrase and in infected cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000015.8 NP_005216.1 E2F1    BIND  PubMed E2F1 interacts with the RAD51 chromatin. 
    NC_000015.8 NP_001941.2 E2F4    BIND  PubMed E2F4 interacts with the RAD51 chromatin. 
    NP_002866.2 NP_000048.1 BLM    BIND  PubMed BLM interacts with RAD51. 
    NP_002866.2 NP_009227.1 BRCA1    BIND  PubMed BRCA1 and Rad51 associate in mitotic and meiotic cells 
    NP_002866.2 NP_000050.1 BRCA2    BIND  PubMed BRCA2 interacts with RAD51. 
    NP_002866.2     BIND  PubMed hRAD51 binds ATP. 
    NP_002866.2     BIND  PubMed hRAD51 binds ADP. 
    NP_002866.2     BIND  PubMed hRAD51 binds to a synthetic ssDNA (oligo-dT-50). 
    NP_597994.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 and Rad51 associate in mitotic and meiotic cells 
    NP_597994.1 NP_000050.1 BRCA2    BIND  PubMed BRCA2 interacts with Rad51. 
    Q06609 P00519 ABL1    HPRD  PubMed  
    Q06609 Q13315 ATM    HPRD  PubMed  
    Q06609 P46100 ATRX    HPRD  PubMed  
    Q06609 Q9P287 BCCIP    HPRD  PubMed  
    Q06609 P54132 BLM    HPRD  PubMed  
    Q06609 P38398 BRCA1    HPRD  PubMed  
    Q06609 P51587 BRCA2    HPRD  PubMed  
    Q06609 P42574 CASP3    HPRD  PubMed  
    Q06609 P55210 CASP7    HPRD  PubMed  
    Q06609 Q12873 CHD3    HPRD  PubMed  
    Q06609 O14757 CHEK1    HPRD  PubMed  
    Q06609 Q14565 DMC1    HPRD  PubMed  
    Q06609 Q96EY1 DNAJA3    HPRD  PubMed  
    Q06609 P18074 ERCC2    HPRD  PubMed  
    Q06609 Q9BXW9 FANCD2    HPRD  PubMed  
    Q06609 Q8IV36 HID1    HPRD  PubMed  
    Q06609 P35568 IRS1    HPRD  PubMed  
    Q06609 Q06609 RAD51    HPRD  PubMed  
    Q06609 Q96B01 RAD51AP1    HPRD  PubMed  
    Q06609 RAD51-associated protein 2 RAD51AP2    HPRD  PubMed  
    Q06609 O43502 RAD51C    HPRD  PubMed  
    Q06609 P43351 RAD52    HPRD  PubMed  
    Q06609 Q9Y620 RAD54B    HPRD  PubMed  
    Q06609 Q92698 RAD54L    HPRD  PubMed  
    Q06609 P27694 RPA1    HPRD  PubMed  
    Q06609 P63165 SUMO1    HPRD  PubMed  
    Q06609 P04637 TP53    HPRD  PubMed  
    Q06609 P63279 UBE2I    HPRD  PubMed  
    Q06609 P08670 VIM    HPRD  PubMed  
    BioGRID:111825 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111825 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:107028 ATRX    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111825 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111825 BioGRID:107110 BLM    BioGRID  PubMed Affinity Capture-Western; Far Western; Two-hybrid 
    BioGRID:111825 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex 
    NP_000050.1 BRCA2    BIND  PubMed BRCA2 interacts with an unspecified isoform of RAD51. 
    BioGRID:111825 BioGRID:107142 BRCA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:111825 BioGRID:13519 BRCA2(IV)    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:122599 BRCC3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:111825 BioGRID:114946 BRE    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:111825 BioGRID:119696 CAB39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111825 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    NP_001265.1 CHEK1    BIND  PubMed Chk1 interacts with RAD51. 
    BioGRID:111825 BioGRID:107536 CHEK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:116316 DMC1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111825 BioGRID:114547 DNAJA3    BioGRID  PubMed Co-localization 
    BioGRID:111825 BioGRID:108259 EIF2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111825 BioGRID:109268 H2AFX    BioGRID  PubMed Co-localization 
    BioGRID:111825 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111825 BioGRID:122776 MCPH1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111825 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111825 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:110575 MSH4    BioGRID  PubMed Co-localization 
    BioGRID:111825 BioGRID:109211 MSH6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:115745 NXF1    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:122843 PALB2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111825 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:131695 POLN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:121212 RAD18    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111825 BioGRID:17483 RAD51    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:111825 RAD51    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-localization; Two-hybrid 
    BioGRID:111825 BioGRID:115879 RAD51AP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111825 BioGRID:111827 RAD51B    BioGRID  PubMed Co-localization 
    BioGRID:111825 BioGRID:111826 RAD51C    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111825 BioGRID:111829 RAD51D    BioGRID  PubMed Co-localization 
    BioGRID:111825 BioGRID:111830 RAD52    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111825 BioGRID:117321 RAD54B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111825 BioGRID:114797 RECQL5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111825 BioGRID:112037 RPA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111825 BioGRID:125639 SFR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111825 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:113188 SUMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:131997 SWI5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111825 BioGRID:125954 SWSAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111825 BioGRID:119942 TERF2IP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111825 BioGRID:117722 TIMM13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111825 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:111825 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111825 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:113205 UGDH    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    BioGRID:111825 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
    BioGRID:111825 BioGRID:113323 WRN    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111825 BioGRID:113350 XRCC2    BioGRID  PubMed Co-localization 
    BioGRID:111825 BioGRID:113351 XRCC3    BioGRID  PubMed Co-localization 
    NP_057864.1 tax    BIND  PubMed Tax interacts with an unspecified isoform of Rad51. 
    • Assembly of the RAD51-ssDNA nucleoprotein complex, organism-specific biosystem (from REACTOME)
      Assembly of the RAD51-ssDNA nucleoprotein complex, organism-specific biosystemThe RAD51-ssDNA nucleoprotein filament is a right-hand helical nucleoprotein filament referred to as the presynaptic filament. This nucleoprotein complex contains a binding site for the double-stra...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
    • DNA damage response, organism-specific biosystem (from WikiPathways)
      DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Homologous DNA pairing and strand exchange, organism-specific biosystem (from REACTOME)
      Homologous DNA pairing and strand exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring...
    • Homologous Recombination Repair, organism-specific biosystem (from REACTOME)
      Homologous Recombination Repair, organism-specific biosystemThe HRR pathway is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs). HRR acts on DSBs occurring within replicated DN...
    • Homologous recombination, organism-specific biosystem (from WikiPathways)
      Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem (from REACTOME)
      Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystemHomologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signalin...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
    • Meiotic Recombination, organism-specific biosystem (from REACTOME)
      Meiotic Recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystem (from REACTOME)
      Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    single-stranded DNA-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA recombinase assembly TAS
    Traceable Author Statement
    more info
    		  
    DNA recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    		  
    DNA unwinding involved in replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-strand break repair TAS
    Traceable Author Statement
    more info
    		  
    double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of DNA ligation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    condensed chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lateral element IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    DNA repair protein RAD51 homolog 1
    Names
    DNA repair protein RAD51 homolog 1
    RAD51 homolog A
    RecA-like protein
    recombination protein A
    RecA, E. coli, homolog of
    RAD51 homolog (RecA homolog, E. coli)
    BRCA1/BRCA2-containing complex, subunit 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012120.1 RefSeqGene

      Range
      4969..41998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164269.1 → NP_001157741.1  DNA repair protein RAD51 homolog 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 2. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC012476, AK131299
      Consensus CDS
      CCDS53931.1
      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (3) summary
      cd01123
      Location:126 – 336
      Blast Score: 808
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR01954
      Location:33 – 80
      Blast Score: 87
      nusA_Cterm_rpt; transcription termination factor NusA, C-terminal duplication
      TIGR02239
      Location:25 – 340
      Blast Score: 1312
      recomb_RAD51; DNA repair protein RAD51

    2. NM_001164270.1 → NP_001157742.1  DNA repair protein RAD51 homolog 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' coding region and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 2. The resulting isoform (3) contains a distinct segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC012476, D14134, EU362635
      Consensus CDS
      CCDS53932.1
      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (2) summary
      cd01123
      Location:102 – 244
      Blast Score: 587
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR01954
      Location:33 – 78
      Blast Score: 83
      nusA_Cterm_rpt; transcription termination factor NusA, C-terminal duplication

    3. NM_002875.4 → NP_002866.2  DNA repair protein RAD51 homolog 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct segment near the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC012476, AK313503, EU362635
      Consensus CDS
      CCDS10062.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000267868, OTTHUMP00000160544, ENST00000267868, OTTHUMT00000252358
      Conserved Domains (3) summary
      cd01123
      Location:102 – 335
      Blast Score: 913
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR01954
      Location:33 – 78
      Blast Score: 85
      nusA_Cterm_rpt; transcription termination factor NusA, C-terminal duplication
      TIGR02239
      Location:25 – 339
      Blast Score: 1603
      recomb_RAD51; DNA repair protein RAD51

    4. NM_133487.3 → NP_597994.3  DNA repair protein RAD51 homolog 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC012476, AK291969, EU362635
      Consensus CDS
      CCDS53931.1
      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (3) summary
      cd01123
      Location:126 – 336
      Blast Score: 808
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR01954
      Location:33 – 80
      Blast Score: 87
      nusA_Cterm_rpt; transcription termination factor NusA, C-terminal duplication
      TIGR02239
      Location:25 – 340
      Blast Score: 1312
      recomb_RAD51; DNA repair protein RAD51

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p10 Primary Assembly

      Range
      40987327..41024356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      17834870..17872189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018926.1 Alternate CHM1_1.0

      Range
      21054942..21092022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01038434.1 (675..6928) None
    genomic ABBA01038435.1 None
    genomic ABBA01038436.1 None
    genomic AC012476.8 (44527..45506) None
    genomic AC022405.5 (105172..111035) None
    genomic AF165088.1 AAD49705.1
    genomic AF203691.1 AAF61901.1
    genomic AF233740.1 AAF69145.1
    genomic AMYH01006565.1 (11515..26620) None
    genomic AMYH01006566.1 None
    genomic AY196785.1 AAN87149.1
    genomic CH471125.1 EAW92431.1
      EAW92432.1
      EAW92433.1
      EAW92434.1
      EAW92435.1
    mRNA AK131299.1 BAD18467.1
    mRNA AK291969.1 BAF84658.1
    mRNA AK303089.1 BAG64200.1
    mRNA AK313503.1 BAG36283.1
    mRNA AU100170.1 None
    mRNA AY425955.1 AAR07948.1
    mRNA AY608888.1 AAT37157.1
    mRNA BC001459.2 AAH01459.1
    mRNA BT019705.1 AAV38511.1
    mRNA CR536559.1 CAG38796.1
    mRNA D13804.1 BAA02962.1
    mRNA D14134.1 BAA03189.1
    mRNA EU362635.1 ABY59731.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06609.1 GenPept UniProtKB/Swiss-Prot:Q06609

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Molecular Biology Databases
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    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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