Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

RAD51 RAD51 recombinase [ Homo sapiens (human) ]

Gene ID: 5888, updated on 17-Apr-2014
Official Symbol
RAD51provided by HGNC
Official Full Name
RAD51 recombinaseprovided by HGNC
Primary source
HGNC:9817
See related
Ensembl:ENSG00000051180; HPRD:01557; MIM:179617; Vega:OTTHUMG00000130067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Location :
15q15.1
Sequence :
Chromosome: 15; NC_000015.10 (40695129..40732158)
See RAD51 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cancer susceptibility candidate 5 Neighboring gene RAD51 antisense RNA 1 (head to head) Neighboring gene regulator of microtubule dynamics 3 Neighboring gene GTP cyclohydrolase I feedback regulator

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Expression of Rad51 enhances basal- and HIV-1 Tat-induced transcription of the HIV-1 LTR promoter; this event requires cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP) PubMed
tat In PC12 cells treated with genotoxic agents, HIV-1 Tat reduces DNA breakage and increases repair of DNA double-strand breaks through a mechanism involving the upregulation of Rad51, a key regulator of homologous recombination in cells PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes HRAD51, during Tat-mediated transactivation of the HIV-1 LTR PubMed
Vpr, p15 vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
vpr HIV-1 Vpr stimulates the focus formation of Rad51 and BRCA1, which are involved in repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) PubMed
pol gag-pol K133A RAD51 mutant remains to bind DNA but is unable to form an active nucleofilament due to the poor binding of ATP, which results in the defect on IN inhibition PubMed
gag-pol RAD51 protein inhibits the integration catalyzed by HIV-1 integrase both in vitro, in yeast expressing integrase and in infected cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Assembly of the RAD51-ssDNA nucleoprotein complex, organism-specific biosystem (from REACTOME)
    Assembly of the RAD51-ssDNA nucleoprotein complex, organism-specific biosystemThe RAD51-ssDNA nucleoprotein filament is a right-hand helical nucleoprotein filament referred to as the presynaptic filament. This nucleoprotein complex contains a binding site for the double-stra...
  • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    BARD1 signaling events, organism-specific biosystem
    BARD1 signaling events
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
  • DNA damage response, organism-specific biosystem (from WikiPathways)
    DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
  • Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
    Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
  • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
    Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Fanconi anemia pathway, conserved biosystem (from KEGG)
    Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Homologous DNA pairing and strand exchange, organism-specific biosystem (from REACTOME)
    Homologous DNA pairing and strand exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring...
  • Homologous Recombination Repair, organism-specific biosystem (from REACTOME)
    Homologous Recombination Repair, organism-specific biosystemThe HRR pathway is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs). HRR acts on DSBs occurring within replicated DN...
  • Homologous recombination, organism-specific biosystem (from WikiPathways)
    Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
  • Homologous recombination, organism-specific biosystem (from KEGG)
    Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination, conserved biosystem (from KEGG)
    Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem (from REACTOME)
    Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystemHomologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signalin...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Meiosis, organism-specific biosystem (from REACTOME)
    Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
  • Meiotic Recombination, organism-specific biosystem (from REACTOME)
    Meiotic Recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystem (from REACTOME)
    Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
DNA recombinase assembly TAS
Traceable Author Statement
more info
 
DNA recombination TAS
Traceable Author Statement
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
 
DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
 
cellular response to camptothecin IDA
Inferred from Direct Assay
more info
 
cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
 
double-strand break repair TAS
Traceable Author Statement
more info
 
double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 
double-strand break repair via homologous recombination TAS
Traceable Author Statement
more info
PubMed 
meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic recombination TAS
Traceable Author Statement
more info
PubMed 
positive regulation of DNA ligation IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
reciprocal meiotic recombination TAS
Traceable Author Statement
more info
PubMed 
regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
condensed nuclear chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
lateral element IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromosome IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA repair protein RAD51 homolog 1
Names
DNA repair protein RAD51 homolog 1
RAD51 homolog A
RecA-like protein
recombination protein A
RecA, E. coli, homolog of
BRCA1/BRCA2-containing complex, subunit 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012120.1 RefSeqGene

    Range
    4969..41998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164269.1NP_001157741.1  DNA repair protein RAD51 homolog 1 isoform 2

    See proteins identical to NP_001157741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 2. Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC012476, AK131299
    Consensus CDS
    CCDS53931.1
    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (3) summary
    TIGR02239
    Location:25340
    Blast Score: 1482
    recomb_RAD51; DNA repair protein RAD51
    cd01123
    Location:116336
    Blast Score: 1023
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:3277
    Blast Score: 127
    HHH_5; Helix-hairpin-helix domain
  2. NM_001164270.1NP_001157742.1  DNA repair protein RAD51 homolog 1 isoform 3

    See proteins identical to NP_001157742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 5' coding region and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 2. The resulting isoform (3) contains a distinct segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC012476, D14134, EU362635
    Consensus CDS
    CCDS53932.1
    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (2) summary
    cd01123
    Location:102258
    Blast Score: 712
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:3280
    Blast Score: 133
    HHH_5; Helix-hairpin-helix domain
  3. NM_002875.4NP_002866.2  DNA repair protein RAD51 homolog 1 isoform 1

    See proteins identical to NP_002866.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct segment near the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC012476, AK313503, EU362635
    Consensus CDS
    CCDS10062.1
    UniProtKB/Swiss-Prot
    Q06609
    Related
    ENSP00000267868, OTTHUMP00000160544, ENST00000267868, OTTHUMT00000252358
    Conserved Domains (3) summary
    TIGR02239
    Location:25339
    Blast Score: 1707
    recomb_RAD51; DNA repair protein RAD51
    cd01123
    Location:102335
    Blast Score: 1081
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:3280
    Blast Score: 134
    HHH_5; Helix-hairpin-helix domain
  4. NM_133487.3NP_597994.3  DNA repair protein RAD51 homolog 1 isoform 2

    See proteins identical to NP_597994.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC012476, AK291969, EU362635
    Consensus CDS
    CCDS53931.1
    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (3) summary
    TIGR02239
    Location:25340
    Blast Score: 1482
    recomb_RAD51; DNA repair protein RAD51
    cd01123
    Location:116336
    Blast Score: 1023
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:3277
    Blast Score: 127
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10

    Range
    40695129..40732158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720626.1XP_006720689.1  

    See proteins identical to XP_006720689.1

    Conserved Domains (3) summary
    TIGR02239
    Location:25339
    Blast Score: 1707
    recomb_RAD51; DNA repair protein RAD51
    cd01123
    Location:102335
    Blast Score: 1081
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:3280
    Blast Score: 134
    HHH_5; Helix-hairpin-helix domain

Alternate HuRef

Genomic

  1. AC_000147.1 Alternate HuRef

    Range
    17834870..17872189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    41107382..41144356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...